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Tourism Destination Recommender System for the Cold Start Problem
( Xiaoyao Zheng ),( Yonglong Luo ),( Zhiyun Xu ),( Qingying Yu ),( Lin Lu ) 한국인터넷정보학회 2016 KSII Transactions on Internet and Information Syst Vol.10 No.7
With the advent and popularity of e-commerce, an increasing number of consumers prefer to order tourism products online. A recommender system can help these users contend with information overload; however, such a system is affected by the cold start problem. Online tourism destination searching is a more difficult task than others on account of its more restrictive factors. In this paper, we therefore propose a tourism destination recommender system that employs opinion-mining technology to refine user preferences and item opinion reputations. These elements are then fused into a hybrid collaborative filtering method by combining user- and item-based collaborative filtering approaches. Meanwhile, we embed an artificial interactive module in our recommender system to alleviate the cold start problem. Compared with several well-known cold start recommendation approaches, our method provides improved recommendation accuracy and quality. A series of experimental evaluations using a publicly available dataset demonstrate that the proposed recommender system outperforms existing recommender systems in addressing the cold start problem.
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Xufeng Xiao,Caijun Wu,Zhiyun Xu,Yingui Yang,Shuying Fan,Heng Wang 한국유전학회 2015 Genes & Genomics Vol.37 No.4
Bolting and flowering enhance the commercial value of flowering Chinese cabbage. FLOWERING LOCUS C (FLC) and FRIGIDA (FRI) are two key flowering time genes in Arabidopsis thaliana. Here we reported on the cloning and characterization of three ‘classical’ genes from the autonomous pathway from flowering Chinese cabbage, BrcuFCA, BrcuFLD and BrcuFVE. The results of expression analysis showed BrcuFLC was a gradually up-regulated with the developmental stages. However, temporal mRNA expression of BrcuFRI, BrcuFCA, BrcuFVE, and BrcuFLD were found to follow the opposite transcription patterns. The spatial expression patterns of BrcuFCA, BrcuFLD, and BrcuFVE were similar with the highest levels in flowers, whereas the highest transcription levels of BrcuFLC occurred in leaves and stems and that of BrcuFRI in roots. We presumed that the main pathway of bolting– flowering regulation in flowering Chinese cabbage might be the autonomous pathway and different from the vernalization pathway and FRI-dependent pathway.
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TIEJUN ZHAO,HEZHONG CHEN,LIXIN YANG,HAI JIN,ZHIGANG LI,LIN HAN,FANGLIN LU,ZHIYUN XU 성균관대학교(자연과학캠퍼스) 성균나노과학기술원 2013 NANO Vol.8 No.2
Oral chemotherapy is a great way to cancer treatment because it is less stressful being that the patient will have less hospital visits and can still maintain a close relationship with health care professionals. In this research, three types of nanoparticle formulation from commercial PCL and self-synthesized TPGS-b-(PCL-ran-PGA) diblock copolymer were fabricated for oral delivery of antitumor agents, including DDAB-modified PCL nanoparticles, unmodified TPGS-b-(PCL-ran-PGA) nanoparticles and DDAB-modified TPGS-b-(PCL-ran-PGA) nanoparticles. Firstly, the TPGS-b-(PCL-ran-PGA) diblock copolymer was synthesized and characterized. DDAB was adopted to increase retention time at the cell surface, thus increasing the chances of nanoparticle uptake by the gastrointestinal mucosa and improving drug absorption. The TPGS-b-(PCL-ran-PGA) nanoparticles were found by FESEM of spherical shape and around 200 nm in diameter. The surface charge of TPGS-b-(PCL-ran-PGA) nanoparticles was reversed from anionic to cationic after DDAB modification. The DDAB-modified TPGS-b-(PCL-ran-PGA) nanoparticles have significantly higher level of the cell uptake than that of DDAB-modified PCL nanoparticles and unmodified TPGS-b-(PCL-ran-PGA) nanoparticles. In vitro cell viability studies showed advantages of the DDAB-modified TPGS-b-(PCL-ran-PGA) nanoparticles over Taxotere® in terms of cytotoxicity against A549 cells. In conclusion, oral chemotherapy by DDAB-modified TPGS-b-(PCL-ran-PGA) nanoparticle formulation may provide a promising outcome for lung cancer patients.
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Wang Qi,Dai Huajie,Hou Tianzhichao,Hou Yanan,Wang Tiange,Lin Hong,Zhao Zhiyun,Li Mian,Zheng Ruizhi,Wang Shuangyuan,Lu Jieli,Xu Yu,Liu Ruixin,Ning Guang,Wang Weiqing,Bi Yufang,Zheng Jie,Xu Min 대한뇌졸중학회 2023 Journal of stroke Vol.25 No.3
Background and Purpose We investigated the causal relationships between the gut microbiota (GM), stroke, and potential metabolite mediators using Mendelian randomization (MR). Methods We leveraged the summary statistics of GM (n=18,340 in the MiBioGen consortium), blood metabolites (n=115,078 in the UK Biobank), and stroke (cases n=60,176 and controls n=1,310,725 in the Global Biobank Meta-Analysis Initiative) from the largest genome-wide association studies to date. We performed bidirectional MR analyses to explore the causal relationships between the GM and stroke, and two mediation analyses, two-step MR and multivariable MR, to discover potential mediating metabolites. Results Ten taxa were causally associated with stroke, and stroke led to changes in 27 taxa. In the two-step MR, <i>Bifidobacteriales</i> order, <i>Bifidobacteriaceae</i> family, <i>Desulfovibrio</i> genus, apolipoprotein A1 (ApoA1), phospholipids in high-density lipoprotein (HDL_PL), and the ratio of apolipoprotein B to ApoA1 (ApoB/ApoA1) were causally associated with stroke (all <i>P</i><0.044). The causal associations between <i>Bifidobacteriales</i> order, <i>Bifidobacteriaceae</i> family and stroke were validated using the weighted median method in an independent cohort. The three GM taxa were all positively associated with ApoA1 and HDL_PL, whereas <i>Desulfovibrio</i> genus was negatively associated with ApoB/ApoA1 (all <i>P</i><0.010). Additionally, the causal associations between the three GM taxa and ApoA1 remained significant after correcting for the false discovery rate (all q-values <0.027). Multivariable MR showed that the associations between <i>Bifidobacteriales</i> order, <i>Bifidobacteriaceae</i> family and stroke were mediated by ApoA1 and HDL_PL, each accounting for 6.5% (<i>P</i>=0.028) and 4.6% (<i>P</i>=0.033); the association between <i>Desulfovibrio</i> genus and stroke was mediated by ApoA1, HDL_PL, and ApoB/ApoA1, with mediated proportions of 7.6% (<i>P</i>=0.019), 4.2% (<i>P</i>=0.035), and 9.1% (<i>P</i>=0.013), respectively. Conclusion The current MR study provides evidence supporting the causal relationships between several specific GM taxa and stroke and potential mediating metabolites.
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