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EXISTENCE OF SOLUTION FOR IMPULSIVE FRACTIONAL DYNAMIC EQUATIONS WITH DELAY ON TIME SCALES
GAO, ZHI-JUAN,FU, XU-YANG,LI, QIAO-LUAN The Korean Society for Computational and Applied M 2015 Journal of applied mathematics & informatics Vol.33 No.3
This paper is mainly concerned with the existence of solution for nonlinear impulsive fractional dynamic equations on a special time scale.We introduce the new concept and propositions of fractional q-integral, q-derivative, and α-Lipschitz in the paper. By using a new fixed point theorem, we obtain some new existence results of solutions via some generalized singular Gronwall inequalities on time scales. Further, an interesting example is presented to illustrate the theory.
Existence of solution for impulsive fractional dynamic equations with delay on time scales
Zhi-Juan Gao,Xu-Yang Fu,Qiao-Luan Li 한국전산응용수학회 2015 Journal of applied mathematics & informatics Vol.33 No.3
This paper is mainly concerned with the existence of solution for nonlinear impulsive fractional dynamic equations on a special time scale. We introduce the new concept and propositions of fractional $q$-integral, $q$-derivative, and $\alpha$-Lipschitz in the paper. By using a new fixed point theorem, we obtain some new existence results of solutions via some generalized singular Gronwall inequalities on time scales. Further, an interesting example is presented to illustrate the theory.
Li, Zheng,Zhang, Li-Juan,Zhang, Hong-Ru,Tian, Gao-Fei,Tian, Jun,Mao, Xiao-Li,Jia, Zheng-Hu,Meng, Zi-Yu,Zhao, Li-Qing,Yin, Zhi-Nan,Wu, Zhen-Zhou Asian Pacific Journal of Cancer Prevention 2014 Asian Pacific journal of cancer prevention Vol.15 No.13
Tumors have evolved numerous mechanisms by which they can escape from immune surveillance. One of these is to produce immunosuppressive cytokines. Transforming growth factor-${\beta}$(TGF-${\beta}$) is a pleiotropic cytokine with a crucial function in mediating immune suppression, especially in the tumor microenvironment. TGF-${\beta}$ produced by T cells has been demonstrated as an important factor for suppressing antitumor immune responses, but the role of tumor-derived TGF-${\beta}$ in this process is poorly understood. In this study, we demonstrated that knockdown of tumor-derived TGF-${\beta}$ using shRNA resulted in dramatically reduced tumor size, slowing tumor formation, prolonging survival rate of tumor-bearing mice and inhibiting metastasis. We revealed possible underlying mechanisms as reducing the number of myeloid-derived suppressor cells (MDSC) and $CD4^+Foxp3^+$ Treg cells, and consequently enhanced IFN-${\gamma}$ production by CTLs. Knockdown of tumor-derived TGF-${\beta}$ also significantly reduced the conversion of na$\ddot{i}$ve $CD4^+$ T cells into Treg cells in vitro. Finally, we found that knockdown of TGF-${\beta}$ suppressed cell migration, but did not change the proliferation and apoptosis of tumor cells in vitro. In summary, our study provided evidence that tumor-derived TGF-${\beta}$ is a critical factor for tumor progression and evasion of immune surveillance, and blocking tumor-derived TGF-${\beta}$ may serve as a potential therapeutic approach for cancer.
Valve core shapes analysis on flux through control valves in nuclear power plants
Jin-yuan Qian,Cong-wei Hou,Juan Mu,Zhi-xin Gao,Zhi-jiang Jin 한국원자력학회 2020 Nuclear Engineering and Technology Vol.52 No.10
Control valves are widely used to regulate fluid flux in nuclear power plants, and there are more than1500 control valves in the primary circuit of one nuclear power plant. With their help, the flux can beregulated to a specific level of water or steam to guarantee the energy efficiency and safety of the nuclearpower plant. The flux characteristics of the control valve mainly depend on the valve core shape. In orderto analyze the effects of valve core shapes on flux characteristics of control valves, this paper focuses onthe valve core shapes. To begin with, numerical models of different valve core shapes are established, andresults are compared with the ideal flux characteristics curve for the purpose of validation. Meanwhile,the flow fields corresponding to different valve core shapes are investigated. Moreover, relationshipsbetween the valve core opening and the outlet flux under different valve core shapes are carried out. Theflux characteristics curve and equation are proposed to predict the outlet flux under different valve coreopenings. This work can benefit the further rese
Positive Association of TEAD1 With Schizophrenia in a Northeast Chinese Han Population
Yang Sun,Lin Wen,Yi-Yang Luo,Wen-Juan Hu,Hui-Wen Ren,Ye Lv,Cong Zhang,Ping Gao,Li-Na Xuan,Guan-Yu Wang,Cheng-Jie Li,Zhi-Xin Xiang,Zhi-Lin Luan 대한신경정신의학회 2023 PSYCHIATRY INVESTIGATION Vol.20 No.12
Objective Schizophrenia is a complex and devastating psychiatric disorder with a strong genetic background. However, much uncertainty still exists about the role of genetic susceptibility in the pathophysiology of schizophrenia. TEA domain transcription factor 1 (TEAD1) is a transcription factor associated with neurodevelopment and has modulating effects on various nervous system diseases. In the current study, we performed a case–control association study in a Northeast Chinese Han population to explore the characteristics of pathogenic <i>TEAD1</i> polymorphisms and potential association with schizophrenia.Methods We recruited a total of 721 schizophrenia patients and 1,195 healthy controls in this study. The 9 single nucleotide polymorphisms (SNPs) in the gene region of <i>TEAD1</i> were selected and genotyped.Results The genetic association analyses showed that five SNPs (rs12289262, rs6485989, rs4415740, rs7113256, and rs1866709) were significantly different between schizophrenia patients and healthy controls in allele or/and genotype frequencies. After Bonferroni correction, the association of three SNPs (rs4415740, rs7113256, and rs1866709) with schizophrenia were still evident. Haplotype analysis revealed that two strong linkage disequilibrium blocks (rs6485989-rs4415740-rs7113256 and rs16911710-rs12364619-rs1866709) were globally associated with schizophrenia. Four haplotypes (C-C-C and T-T-T, rs6485989-rs4415740-rs7113256; G-T-A and G-T-G, rs16911710-rs12364619-rs1866709) were significantly different between schizophrenia patients and healthy controls.Conclusion The current findings indicated that the human <i>TEAD1</i> gene has a genetic association with schizophrenia in the Chinese Han population and may act as a susceptibility gene for schizophrenia.