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RISS 인기검색어
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- 저자 : Zhanpeng Li (검색결과 3 건)
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Peng Lan,Liang Li,Zhanpeng Tie,Haiyan Tang,Jiaquan Zhang 대한금속·재료학회 2019 METALS AND MATERIALS International Vol.25 No.6
A plane stress model was developed to study the coupled effect of mold taper and corner radius on the thermal–mechanicalbehavior of a 250 mm × 280 mm continuously cast bloom for a given special steel. Good agreement was obtained in both shellthickness and the off-corner cracking location from modeling and trial experiment. The results show that increasing moldtaper results in the obvious decrease of surface temperature near the corner, while enlarging mold corner radius makes theshell surface temperature at the corner region more even with the mold taper between 0 and 1.5% m−1. It is also found thatboth the mold corner radius and taper are the key factors influencing the shell crack sensitivity but with different mechanism. For the internal crack, the mold taper takes more dominant effect for its corner radius between 0–10 mm, as the hoop strainat the solidification front decreases with increasing mold taper. For the surface crack, more sensitivity is noticed to the moldcorner radius. Increasing mold corner radius leads to the increase of the surface hoop strain in the corner region, almostregardless of mold taper. The proper mold taper and corner radius for the present bloom casting should be 1.0–1.5% m−1and 15–25 mm respectively.
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Ten paths of PKA signaling pathway regulate hepatocyte proliferation in rat liver regeneration
Zhenchao Cheng,Lijuan Duan,Xiaoxia Hao,Zhanpeng Li,Gaiping Wang,Cunshuan Xu 한국유전학회 2012 Genes & Genomics Vol.34 No.4
Generally, protein kinase A (PKA) signaling pathway regulates many physiological activities such as cell proliferation and metabolism. However, little is known about how PKA signaling pathway composed of 16 paths participates in regulating hepatocyte proliferation during rat liver regeneration (LR). To explore the influence PKA signaling pathway upon hepatocytes at gene transcription level, Rat Genome 230 2.0 Array was used to detect expression changes of 225 related genes in isolated hepatocytes from rat regenerating livers, showing that 197 genes were contained in the array and 78 genes were significantly changed. Moreover, bioinformatics and systems biology methods were applied to analyze the precise role of PKA signaling pathway in regulating hepatocyte proliferation during LR, and it was found that 10 paths were related to hepatocyte proliferation during rat LR. In detail, 5 paths including SR→Gα-S→PKA, GPCR→Gα-S→PKA, GPCR→PLC→PKA, ET-1→PLC→PKA and hypoxia→AMP→PKA launched hepatocyte proliferation in initiating phase of LR,and then 3 paths including βR→Gα-S→PKA, GPCR→PLC→PKA and GPCR→Gβγ ┤AcⅤⅥ→PKA enhanced hepatocyte proliferation in progressing phase, whereas 3 paths including TGFB→SMAD3/4→PKA, CaCn→ACIX ┤PKA, SST→Gα-I ┤PKA inhibited hepatocyte proliferation in terminating phase of LR. In conclusion, 78 genes and 10 paths of PKA signaling pathway regulate hepatocyte proliferation in rat LR.
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Hongwang Du,Hancong Xu,Jialong Li,Zhanpeng Zhou 대한기계학회 2023 JOURNAL OF MECHANICAL SCIENCE AND TECHNOLOGY Vol.37 No.11
The thermal load in the piston head is becoming heavy with the application of supercharging technology. This makes the piston cooling become more challenging to ensure the reliability of the piston. In this study, an oil-injection cooling process in a medium-speed Vtype diesel engine is numerically investigated. The simulations are performed for the direct coupling of the piston head structure and the two-phase flow in the cooling gallery. The effect of the flow pattern on heat transfer characteristics during the whole process is discussed. The results reveal a series of the flow characteristics including thrown flow, interrupted flow, wall impingement, oil oscillating and sedimentation during the reciprocating movement of the piston and the flow characteristics become more obvious with the increase of the engine speed, but the cooling oil is more widely distributed in the oil gallery due to more intense oscillation. After multi-cycle calculations, the flow characteristics of the cooling oil and the heat transfer characteristics of the piston both have a certain periodicity.
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