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RISS 인기검색어
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- 저자 : Zhang Ziji (검색결과 6 건)
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AERODYNAMIC CHARACTERISTICS OF MIRA FASTBACK MODEL IN EXPERIMENT AND CFD
Yingchao Zhang,Jintao Zhang,Kaiguang Wu,Zijie Wang,Zhe Zhang 한국자동차공학회 2019 International journal of automotive technology Vol.20 No.4
The lasting high fuel cost has recently inspired the resurgence in drag reduction research for vehicles, which calls for a thorough understanding of the vehicle wake. The acknowledged MIRA fastback vehicle model is characterized by similar real vehicle geometry, thus it is especially suitable for the above purpose. In spite of a considerable number of previous investigations, our knowledge of flow around this model remains incomplete. This paper aims to visit turbulent flow structure behind this model. An investigation has been conducted to measure the near wake flow structure of the MIRA 1/8 scale mode, using both Particle Image Velocimetry (PIV) experimental method and Computational Fluid Dynamics (CFD) simulation method. In order to capture the flow structure accurately, PIV measurement was performed in different sections along three orthogonal directions, and the CFD method acquired additional simulation results to catch the better flow status. Through the maps of the time-averaged vorticity, the instantaneous vorticity and the handled velocity vector from the PIV and CFD methods, we found out the formation mechanism of the transient flow of fastback model and summed up the schematic of flow structure. This study not only analyzed the vortex shedding characteristics of turbulent near wake, but more importantly provided insight into the complex three-dimensional features of the flow structure in the wakes of MIRA fastback model.
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Shu Hu,Xiaoyi Zhao,Guping Mao,Ziji Zhang,Xingzhao Wen,Chengyun Zhang,Weiming Liao,Zhiqi Zhang 생화학분자생물학회 2019 Experimental and molecular medicine Vol.51 No.-
MicroRNAs (miRNAs, miR) play a key role in the pathogenesis of osteoarthritis (OA). Few studies have examined theregulatory role of P21-activated kinases (PAKs), a family of serine/threonine kinases, in OA. The aim of this study was todetermine whether miR-455-3p can regulate cartilage degeneration in OA by targeting PAK2. MiR-455-3p knockoutmice showed significant degeneration of the knee cartilage. MiR-455-3p expression increased and PAK2 expressiondecreased in the late stage of human adipose-derived stem cell (hADSC) chondrogenesis and in chondrocytesaffected by OA. Furthermore, in both miR-455-3p-overexpressing chondrocytes and PAK2-suppressing chondrocytes,cartilage-specific genes were upregulated, and hypertrophy-related genes were downregulated. A luciferase reporterassay confirmed that miR-455-3p regulates PAK2 expression by directly targeting the 3′-untranslated regions (3′UTRs)of PAK2 mRNA. IPA-3, a PAK inhibitor, inhibited cartilage degeneration due to OA. Moreover, suppressing PAK2promoted R-Smad activation in the TGF/Smad signaling pathway in chondrocytes. Altogether, our results suggest thatmiR-455-3p promotes TGF-β/Smad signaling in chondrocytes and inhibits cartilage degeneration by directlysuppressing PAK2. These results thus indicate that miR-455-3p and PAK2 are novel potential therapeutic agents andtargets, respectively, for the treatment of OA.
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The long non-coding RNA uc.4 influences cell differentiation through the TGF-beta signaling pathway
Zijie Cheng,Qijun Zhang,Anwen Yin,Mengwen Feng,Hua Li,Hailang Li,Yun Li,Lingmei Qian 생화학분자생물학회 2018 Experimental and molecular medicine Vol.50 No.-
In a previous study, we screened thousands of long non-coding RNAs (lncRNAs) to assess their potential relationship with congenital heart disease (CHD). In this study, uc.4 attracted our attention because of its high level of evolutionary conservation and its antisense orientation to the CASZ1 gene, which is vital for heart development. We explored the function of uc.4 in cells and in zebrafish, and describe a potential mechanism of action. P19 cells were used to investigate the function of uc.4. We studied the effect of uc.4 overexpression on heart development in zebrafish. The overexpression of uc.4 influenced cell differentiation by inhibiting the TGF-beta signaling pathway and suppressed heart development in zebrafish, resulting in cardiac malformation. Taken together, our findings show that uc.4 is involved in heart development, thus providing a potential therapeutic target for CHD.
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Solution and analysis of VL combined seal lubrication model under the effect of wear
Yi Zhang,Siyang Xiong,Sipeng Zhong,Zijie Xiong,Qiang Yang 대한기계학회 2022 JOURNAL OF MECHANICAL SCIENCE AND TECHNOLOGY Vol.36 No.11
Through the finite element calculation of VL combined seal models under different wear conditions, contact pressure distributions of models are obtained. Considering the coupling effect between seal deformation and lubricating oil film, a mathematical model of elastohydrodynamic lubrication for VL combined seal is established. Based on the theory of small deformation, the elastic deformation of VL composite seal under high pressure is obtained by the deformation influence coefficient matrix method. Considering the influence of sealing surface wear and surface roughness, the oil film thickness distribution and oil film pressure distribution of VL combined seal are solved by the finite difference method. The analysis results show the wear of VL combined seal, the decrease of viscosity, the increase of roughness and rotational speed can raise the thickness and pressure of lubricating oil film. The correctness of numerical simulation is verified by experimentally measuring the friction torque and leakage rate of seal.
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Xu Yiyang,Mao Guping,Long Dianbo,Deng Zengfa,Xin Ruobin,Zhang Ziji,Xue Ting,Liao Weiming,Xu Jie,Kang Yan 생화학분자생물학회 2022 Experimental and molecular medicine Vol.54 No.-
Osteoarthritis, characterized by articular cartilage degradation, is the leading cause of chronic disability in older adults. Studies have indicated that circular RNAs are crucial regulators of chondrocyte development and are involved in the progression of osteoarthritis. In this study, we investigated the function and mechanism of a circular RNA and its potential for osteoarthritis therapy. The expression levels of circCREBBP, screened by circular RNA sequencing during chondrogenic differentiation in adipose tissue-derived stem cells, and TGFβ2 were significantly increased in the cartilage of patients with osteoarthritis and IL-1β-induced chondrocytes. circCREBBP knockdown increased anabolism in the extracellular matrix and inhibited chondrocyte degeneration, whereas circCREBBP overexpression led to the opposite effects. Luciferase reporter assays, rescue experiments, RNA immunoprecipitation, and RNA pulldown assays confirmed that circCREBBP upregulated TGFβ2 expression by sponging miR-1208, resulting in significantly enhanced phosphorylation of Smad1/5 in chondrocytes. Moreover, intra-articular injection of adeno-associated virus-sh-circCrebbp alleviated osteoarthritis in a mouse model of destabilization of the medial meniscus. Our findings reveal a critical role for circCREBBP in the progression of osteoarthritis and provide a potential target for osteoarthritis therapy.
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