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Shin, Injae,Zamfir, Alina D,Ye, Bin Humana Press 2008 METHODS IN MOLECULAR BIOLOGY -CLIFTON THEN TOTOWA- Vol.441 No.-
<P>Carbohydrate modification of proteins and lipids serves to functionally 'fine-tune' these molecules, which are involved in a wide variety of physiological and pathogenic processes through specific biological interactions. Therefore, errors in glycosylation have severe implications and have been associated with many common diseases such as cancer and diabetes. Carbohydrates have historically been desirable targets for drug invention. Recent advances in detection and analysis of carbohydrates have facilitated understanding of the roles of glycoproteins and carbohydrates in many cellular and signaling processes, paving the way for the exploitation of carbohydrates in disease diagnosis and drug discovery. Here, we introduce the most recently developed analytical methods, which have been routinely used in many research laboratories. Following the protein separation by one-dimensional (1D) and two-dimensional (2D) polyacrylamide gel electrophoresis (PAGE), gel-based staining methods provide the initial step to identify candidate glycoproteins so that further characterization can proceed. Combined liquid chromatography and mass spectrometry provide an invaluable technology for quantitative analysis of glycoproteins including glycopeptides and glycans and to identify the glycosylation site. The advanced technology of the carbohydrate-based microarray system incorporates high-throughput analysis to extend the scope of biomedical research on carbohydrate-mediated molecular interactions.</P>
Alumina-coated silicon-based nanowire arrays for high quality Li-ion battery anodes
Nguyen, Hung Tran,Zamfir, Mihai Robert,Duong, Loc Dinh,Lee, Young Hee,Bondavalli, Paolo,Pribat, Didier The Royal Society of Chemistry 2012 Journal of materials chemistry Vol.22 No.47
<P>Amongst other requirements, a good anode for Li-ion battery applications must exhibit dimensional stability upon Li insertion, as well as chemical inertness with respect to the electrolyte. This latter characteristic is usually provided by the so-called solid electrolyte interphase (SEI), a passivating film that is formed at the end of the first lithiation step, originating from the partial reduction of the electrolyte and Li salt. However, silicon, which exhibits the highest known capacity for Li alloying, possesses none of the above attributes when used as an anode material. Actually, the large volume expansion of Si upon alloying with Li induces a mechanical instability of the SEI film, which therefore fails to provide its protective role. In this paper, we have studied the effect of thin alumina deposits on top of Si-based nanowires. A thin alumina deposit will act as a substitute for the SEI, preventing electrolyte decomposition. We observe that even if alumina films crack during lithiation–delithiation steps of the Si-based nanowires, they still provide some kind of protection, prolonging the lifetime of the anode. Using Al<SUB>2</SUB>O<SUB>3</SUB>-coated Si-based nanowires, we have been able to obtain a lifetime of 1280 cycles when the capacity of the anode was limited to 1200 mA h g<SUP>−1</SUP>. We also show that uncoated Si nanowires degrade more rapidly when cycled under identical conditions.</P> <P>Graphic Abstract</P><P>We have studied the effect of thin Al<SUB>2</SUB>O<SUB>3</SUB> coatings on Si-based nanowires for Li-ion battery anodes. We report a lifetime of 1280 cycles when the capacity is limited to 1200 mA h g<SUP>−1</SUP>. <IMG SRC='http://pubs.rsc.org/services/images/RSCpubs.ePlatform.Service.FreeContent.ImageService.svc/ImageService/image/GA?id=c2jm35125k'> </P>
A glimpse to the resident life in a hepato-biliary-pancreatic team
Mara MARDARE,Alina PUSCASU,Victor BURLOIU,Andrei VACARASU,Irina BONDOC,Andrada SPANU,Razvan IOSIFESCU,Marius ZAMFIR,Niculae IORDACHE,Octav GINGHINA,Radu GHENADE,Camelia CALIN 한국간담췌외과학회 2021 Annals of hepato-biliary-pancreatic surgery Vol.25 No.-