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        Outcomes of salvage liver transplant for recurrent hepatocellular carcinoma

        Yuxin Guo,Ek-Khoon Tan,Thinesh-Lee Krishnamoorthy,Chee-Kiat Tan,Ban-Hock Tan,Thuan-Tong Tan,Ser-Yee Lee,Chung-Yip Chan,Peng-Chung Cheow,Alexander Y. F. Chung,Prema Raj Jeyaraj,Brian K. P. Goh 한국간담췌외과학회 2019 Annals of hepato-biliary-pancreatic surgery Vol.23 No.1

        Backgrounds/Aims: Salvage liver transplantation (SLT) is a therapeutic strategy for recurrent hepatocellular carcinoma (HCC). However, it remains controversial with compromised survival outcomes and increased perioperative morbidity compared to primary liver transplant (PLT). In the present work, we describe our institution’s experience on SLT by comparing outcomes of SLT to PLT for HCCs. Methods: Retrospective analysis was conducted for 49 transplant patients from 2006-2017. A comparative analysis was carried out between 14 SLT patients and 35 PLT patients. Results: SLT patients demonstrated significantly shorter time to recurrence than PLT patients (median=5.5 versus 23 months, p<0.001) with a trend towards increased perioperative major morbidity (42.9% versus 37%, p=0.711), inferior 5-year overall survival (61% versus 75%, p=0.345) and inferior 5-year recurrence-free survival (57% versus 72%, p=0.263). However, overall survival from the point of primary resection over a 10-year period showed no statistical difference between the 2 groups (SLT=60% versus PLT=61%, p=0.685). Conclusions: SLT is a viable treatment strategy for HCCs. However, it exhibited poorer short-term perioperative and oncologic outcomes than PLT. SLT requires better patient selection with liver donor grafts for optimization of resource allocation in this era of organ shortage. Considering the worldwide shortages in liver grafts, it is hypothesized that optimization of a salvage transplant strategy may improve resource allocation and reap optimal patient outcomes.

      • KCI등재

        Thermal Analysis and Design of AlGaInP-based Light Emitting Diode Arrays

        Zhang Ban,Zhongzhu Liang,Jingqiu Liang,Weibiao Wang,JinguangLv,Yuxin Qin 한국광학회 2017 Current Optics and Photonics Vol.1 No.2

        LED arrays with pixel numbers of 3×3, 4×4, and 5×5 have been studied in this paper in order to enhancethe optical output power and decrease heat dissipation of an AlGaInP-based light emitting diode displaydevice (pixel size of 280×280 μm) fabricated by micro-opto-electro-mechanical systems. Simulation resultsshowed that the thermal resistances of the 3×3, 4×4, 5×5 arrays were 52°C/W, 69.7°C/W, and 84.3°C/W. The junction temperature was calculated by the peak wavelength shift method, which showed that themaximum value appears at the center pixel due to thermal crosstalk from neighboring pixels. The centraltemperature would be minimized with 40 μm pixel pitch and 150 μm substrate thickness as calculated bythermal modeling using finite element analysis. The modeling can be used to optimize parameters of highlyintegrated AlGaInP-based LED arrays fabricated by micro-opto-electro-mechanical systems technology.

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        Influence of Layer Thickness Ratio on the Mechanical and Failure Properties of Soft-Hard Interbedded Rock-like Material

        Qiang Xie,Hao Gao,Yuxin Ban,Xiang Fu,Xiaowen Liang,Zhilin Cao,Jun Duan 대한토목학회 2023 KSCE Journal of Civil Engineering Vol.27 No.11

        To figure out the influence of soft-hard layer thickness ratio on specimens’ mechanical properties evolution and microcracking mechanism, combined with digital image correlation technology and acoustic emission facility, uniaxial compression tests were conducted on soft-hard interbedded rock-like materials considering seven bedding dip angles and two soft-hard layer thickness ratios. The results are as follows: 1) The failure mode and failure pattern of layered rock masses are mainly determined by the bedding dip angle α and are less related to the soft-hard thickness ratio. With the increase of dip angle, the failure strength curve of the specimen is approximately U-shaped, and the soft-hard layer thickness ratio affects the U-shaped. The decrease in soft-hard layer thickness ratio will reduce the uniaxial compressive strength of specimens with low dip angles (α≦30°), cause differences in the evolution path of local strain fields of layered rock masses and reduce the horizontal displacement of the main crack. 2) The increase of the proportion of soft layer in the soft-hard layer thickness ratio will reduce the proportion of tensile cracks in the tensile failure specimens and shear cracks in the shear failure specimens, complicating the process of cracks of the layer rock mass. 3) Increasing the proportion of soft layers in the soft-hard layers thickness ratio promotes the generation of secondary cracks in layered rock masses and further reduces the integrity of specimens. Finally, through the findings in this paper, it can provide a reference for analyzing the crack propagation behavior of layered rock.

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