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        <i>Pterocarpus santalinus</i> L. Regulated Ultraviolet B Irradiation-induced Procollagen Reduction and Matrix Metalloproteinases Expression Through Activation of TGF-<i>β</i> /Smad and Inhibition of the MAPK/AP-1 Pathway in Normal Human Dermal Fibroblas

        Gao, Wei,Lin, Pei,Hwang, Eunson,Wang, Yushuai,Yan, Zhengfei,Ngo, Hien T.T.,Yi, Tae-Hoo Pergamon Press 2018 Photochemistry and photobiology Vol.94 No.1

        <P>Ultraviolet light-induced reactive oxygen species (ROS) damage human skin and prematurely cause aging. A growing body of research is focusing on considering plants and plant-derived compounds as antiphotoaging therapeutic material. Pterocarpus santalinus L., as an Indian traditional medicine, possesses antidiabetic, anti-inflammatory and antioxidative effects. Here, we studied the antiphotoaging effects of ethanolic extract of P. santalinus L. heartwood (EPS) on ultraviolet radiation B (UVB)-irradiated normal human dermal fibroblasts (NHDFs). Results showed that EPS significantly inhibited the upregulation of matrix metalloproteinases and IL-6 caused by UVB irradiation, and suppressed UVB-induced phosphorylation of extracellular signal-regulated kinase, Jun N-terminal kinase and p38, as well as the activation of AP-1 transcription factors. Further study indicated that UVB-induced production of MMP-1 and IL-6 could be inhibited by PD 98059 (an ERK inhibitor) and SP600125 (A JNK inhibitor), implied that EPS inhibited UVB-induced MMP-1 and IL-6 secretion by inactivating MAPK signaling pathway. In addition, EPS possessed an excellent antioxidant activity, which could increase cytoprotective antioxidants such as HO-1, NQ-O1 expression by facilitating the nuclear accumulation of Nrf2. Treatment of NHDFs with EPS also recovered UVB-induced procollagen type I reduction by activating TGF-beta/Smad pathway. These findings demonstrated that EPS had a potential effect against UVB-induced skin photoaging.</P>

      • Mechanical properties of new stainless steel-aluminum alloy composite joint in tower structures

        Yingying Zhang,Qiu Yu,Wei Song,Junhao Xu,Yushuai Zhao,Baorui Sun 국제구조공학회 2023 Steel and Composite Structures, An International J Vol.49 No.5

        Tower structures have been widely used in communication and transmission engineering. The failure of joints is the leading cause of structure failure, which make it play a crucial role in tower structure engineering. In this study, the aluminum alloy three tube tower structure is taken as the prototype, and the middle joint of the tower was selected as the research object. Three different stainless steel-aluminum alloy composite joints (SACJs), denoted by TA, TB and TC, were designed. Finite element (FE) modeling analysis was used to compare and determine the TC joint as the best solution. Detail requirements of fasteners in the TC stainless steel-aluminum alloy composite joint (TC-SACJ) were designed and verified. In order to systematically and comprehensively study the mechanical properties of TC-SACJ under multi-directional loading conditions, the full-scale experiments and FE simulation models were all performed for mechanical response analysis. The failure modes, loadcarrying capacities, and axial load versus displacement/stain testing curves of all full-scale specimens under tension/compression loading conditions were obtained. The results show that the maximum vertical displacement of aluminum alloy tube is 26.9mm, and the maximum lateral displacement of TC-SACJs is 1.0 mm. In general, the TC-SACJs are in an elastic state under the design load, which meet the design requirements and has a good safety reserve. This work can provide references for the design and engineering application of aluminum alloy tower structures.

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        Thermal history of the Jurassic marine sequences in the Qiangtang Basin, northern Tibetan Plateau: implication for the hydrocarbon preservation

        Mingming Fei,Licheng Wang,Yalin Li,Yushuai Wei 한국지질과학협의회 2016 Geosciences Journal Vol.20 No.4

        The Jurassic marine sequences of the Qiangtang Basin in the northern part of the Tibet Plateau have the best petroleum exploration prospect. The prototype basin has undergone multi-stage and complicated tectonic events since the Cretaceous, especially the mid-Cretaceous tectonic event and the Cenozoic uplift of Tibetan Plateau. However, little information about the impact of these tectonic events on petroleum preservation has been done. In this paper, the burial and thermal histories modeling using vitrinite reflectance (Ro) are used to characterize the impact. The results showed that there is a regional falling of palaeotemperature in the Qiangtang Basin during the mid-Cretaceous indicating a regional tectonic event caused by the collision between Lhasa and Qiangtang blocks. However, the Cenozoic tectonic event caused by the uplift of Tibetan Plateau since 30 Ma was only recorded in the Southern Qiangtang Depression and not obvious in the Northern Qiangtang Depression, which indicates that uplift-denudation caused by the mid-Cretaceous tectonic event was extensive in whole Qiangtang Basin and more significant to the hydrocarbon accumulation than those in the Cenozoic. The event could damage the previously formed hydrocarbon traps and caused the leaking of cap-rocks for the dramatically denudation especially in the Southern Qiangtang Depression. We speculated that the Northern Qiangtang Depression has the lower thickness of denudation and barely influenced by the Cenozoic tectonic events and thus is primary exploration target for gas or gas hydrate.

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        FEM Simulation and Test Verification of PD Ultrasonic Signal Propagation in a Power Transformer Model

        Zan Wang,Chaofei Gao,Liwei Zheng,Jikun Ren,Wei Wang,Yushuai Zhang,Shijie Han 대한전기학회 2021 Journal of Electrical Engineering & Technology Vol.16 No.1

        Ultrasonic signals will be generated when partial discharge occurs in internal insulation faults in large oil immersed power transformers: because the ultrasonic signal has strong anti-interference ability and has no direct electromagnetic contact with the equipment, it is widely used in transformer fault detection and positioning. In this paper, the fi nite element method (FEM) is used to simulate the ultrasonic signal in a 35 kV power transformer. The infl uence of transformer case on ultrasonic signal propagation is considered, and the propagation law of the ultrasonic signal inside the transformer is obtained. Fabry–Pérot (F–P) fi bre acoustic sensors with a centre frequency of 28 kHz were fabricated. A partial discharge detection test was carried out in a 35 kV transformer winding model using the F–P sensors. The test results show that the ultrasonic waveform detected by the F–P sensors are in good agreement with the simulation results, and the propagation of the ultrasonic wave inside the transformer is verifi ed. It lays a foundation for detecting and locating PDs in power transformer by F–P acoustic sensors.

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