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Miaomiao Niu,Lei Xiang,Yaqian Liu,Yuqiong Zhao,Jifang Yuan,Xin Dai,Hua Chen 아세아·태평양축산학회 2017 Animal Bioscience Vol.30 No.8
Objective: Adipose tissue is no longer considered as an inert storage organ for lipid, but instead is thought to play an active role in regulating insulin effects via secretion adipokines. However, conflicting reports have emerged regarding the effects of adipokines. In this study, we investigated the role of adipokines in glucose metabolism and insulin sensitivity in obese Bama mini-pigs. Methods: An obesity model was established in Bama mini-pigs, by feeding with high-fat and high-sucrose diet for 30 weeks. Plasma glucose and blood biochemistry levels were measured, and intravenous glucose tolerance test was performed. Adipokines, including adiponectin, interleukin-6 (IL-6), resistin and tumor necrosis factor alpha (TNF-α), and glucose-induced insulin secretion were also examined by radioimmunoassay. AMP-activated protein kinase (AMPK) phosphorylation in skeletal muscle, which is a useful insulin resistance marker, was examined by immunoblotting. Additionally, associations of AMPK phosphorylation with plasma adipokines and homeostasis model assessment of insulin resistance (HOMA-IR) index were assessed by Pearce's correlation analysis. Results: Obese pigs showed hyperglycemia, high triglycerides, and insulin resistance. Adiponectin levels were significantly decreased (p<0.05) and IL-6 amounts dramatically increased (p<0.05) in obese pigs both in serum and adipose tissue, corroborating data from obese mice and humans. However, circulating resistin and TNF-α showed no difference, while the values of TNF-α in adipose tissue were significantly higher in obese pigs, also in agreement with data from obese humans but not rodent models. Moreover, strong associations of skeletal muscle AMPK phosphorylation with plasma adiponectin and HOMA-IR index were obtained. Conclusion: AMPK impairment induced by adiponectin decrease mediates insulin resistance in high-fat and high-sucrose diet induction. In addition, Bama mini-pig has the possibility of a conformable model for human metabolic diseases.
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Hao Wang,Qian Yuan,Linjiang Chai,Ke Zhao,Ning Guo,Jun Xiao,Xing Yin,Bin Tang,Yuqiong Li,Shaoyu Qiu 한국원자력학회 2022 Nuclear Engineering and Technology Vol.54 No.6
A typical ferritic/martensitic (F/M) steel sheet was subjected to pulsed laser surface remelting (LSR) andcorrosion test in lead-bismuth eutectic (LBE) at 550 C. There present two modification zones withdistinct microstructures in the LSRed specimen: (1) remelted zone (RZ) consisting of both bulk d-ferritegrains and martensitic plates and (2) heat-affected zone (HAZ) below the RZ, mainly composed ofmartensitic plates and high-density precipitates. Martensitic transformation occurs in both the RZ andthe HAZ with the Kurdjumov-Sachs and Nishiyama-Wassermann orientation relationships followedconcurrently, resulting in scattered orientations and specific misorientation characteristics. Hardnessesof the RZ and the HAZ are 364 ± 7 HV and 451 ± 15 HV, respectively, considerably higher than that of thematrix (267 ± 3 HV). In oxygen-saturated and oxygen-depleted LBE, thicknesses of oxide layers developed on both the as-received and the LSRed specimens increase with prolonging corrosion time (oxidelayers always thinner under the oxygen-depleted condition). The corrosion resistance of the LSRed F/Msteel in oxygen-saturated LBE is improved, which can be attributed to the grain-refinement acceleratedformation of dense FeeCr spinel. In oxygen-depleted LBE, the growth of oxide layers is very low withboth types of specimens showing similar corrosion resistance
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Nutrigenomics reveals potential genetic underpinning of diverse taste preference of Chinese men
Zhouhai Zhu,Junpu Mei,Silong Sun,Sheming Lu,Meng Li,Ying Guan,Ying Chen,Yuqiong Xu,Tao Zhang,Fengxue Shi,Xuemei Li,Mingming Miao,Shancen Zhao,Qian Gao,Qili Mi,Ping Tang,Jianhua Yao 한국유전학회 2021 Genes & Genomics Vol.43 No.6
Background Taste preference varies geographically in China. However, studies on Chinese people’s taste preference in different regions of China are limited, and are lack of research on the mechanism of diferences in taste preference, especially in genetics. Objective This study aims to investigate the characteristics of taste preference of Chinese men, and estimate whether diverse taste preference in Chinese have genetic underpinning. Methods We conducted a questionnaire survey on taste preferences on 1076 males from 10 regions of China, and collected another 1427 males from the same regions which genotyped by microarray. We compared the correlation between diferent taste preference, and evaluated the correlation between the mutation frequency of inhouse database and diferent taste preference. The putative taste-preference-related genes were further utilized to estimate the candidate relationship on gene and gene network in diferent taste preference. Results There was a correlation between diferent taste preferences in Chinese men. We found 31 SNPs associated with 6 kind of taste preferences. These SNPs located within or nearby 36 genes, and the tastes associated with 4 of these genes (TRPV1, AGT, ASIC2 and GLP1R) are consistent with the previous studies. Moreover, in diferent tastes which were suggested to be associated with each other, some putative related genes were the same or in the same gene network, such as pathways related with blood pressure, response to stimulus and nervous system. Conclusions This study indicates that the diverse taste preference of Chinese men may have genetic underpinning.
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