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- 저자 : Yumiko Takano (검색결과 2 건)
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Hiroaki Okayasu,Yuji Ozeki,Kumiko Fujii,Yumiko Takano,Takahiro Shinozaki,Masami Ohrui,Kazutaka Shimoda 대한신경정신의학회 2019 PSYCHIATRY INVESTIGATION Vol.16 No.2
Objective: Some antidepressants have been implicated as risk factors for QT prolongation, which is a predictor of sudden cardiac death. However, the QT interval is considered an imperfect biomarker for proarrhythmic risk. Therefore, we reevaluated the risk of sudden cardiac death due to antidepressants using improved methods, namely, QT dispersion (QTD), T wave peak-to-end interval (Tp-e), and Tp-e/QT ratio. Methods: We compared the effects of antidepressants on QTc (QT/RR1/3), QTD, Tp-e, and Tp-e/QT ratio in 378 patients with mood disorder. We also compared each index between 165 healthy controls and 215 randomly selected age-matched patients. Results: Age (p<0.01), sex (p<0.05), tricyclic antidepressant (TCA) use (p<0.05), and clomipramine (p<0.01) and mianserin (p<0.05) use in particular, significantly associated with a prolonged QTc. We also found that age (p<0.01), TCA use (p<0.05), and clomipramine (p<0.01) and mianserin (p<0.05) use in particular, significantly prolonged QTD. However, there was no correlation between each variable and Tp-e or Tp-e/QT ratio. Significant differences in QTc and QTD were found between the patients and healthy controls. Conclusion: From our results, prediction of risk of sudden cardiac death by QTD, Tp-e, or Tp-e/QT ratio was inconsistent. Increased QTD may be more suitable for predicting sudden cardiac death due to antidepressants.
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Cardiac Rehabilitation Increases Exercise Capacity with a Reduction of Oxidative Stress
Taira Fukuda,Miwa Kurano,Kazuya Fukumura,Tomohiro Yasuda,Haruko Iida,Toshihiro Morita,Yumiko Yamamoto,Nami Takano,Issei Komuro,Toshiaki Nakajima 대한심장학회 2013 Korean Circulation Journal Vol.43 No.7
Background and Objectives: Reactive oxygen species (ROS) mediate various signaling pathways that underlie vascular inflammation in atherogenesis and cardiovascular diseases. Cardiac rehabilitation (CR) has a variety of multiple beneficial effects, including anti-inflam -matory effects. The purpose of the present study was to investigate the effects of CR on ROS in patients with cardiovascular diseases. Subjects and Methods: The serum level of derivatives of reactive oxidative metabolites, an index of oxidative stress, was measured in 100 patients with cardiovascular diseases before, and, subsequently, 3 and 6 months after, CR. A biological antioxidant potential (BAP) test was applied to assess the antioxidant power of the serum. Results: The resting reactive oxidative metabolite levels decreased 3-6 months after CR {pre: 351±97 Carratelli unit (CARR U), 3 months:329±77 CARR U, 6 months: 325±63 CARR U, all p<0.01} with the increase of the percentage of the predicted values of V˙O 2 peak and the percentage of the predicted values of V˙O 2 at the anaerobic threshold (V˙O 2 AT ) and the decrease of the B-type natriuretic peptide (BNP). The BAP test and antioxidative/oxidative stress ratio increased 6 months after CR. The % changes of the antioxidative/oxidative stress ratio was positively correlated with the % changes of V˙O 2 AT , and negatively correlated with the % changes of the BNP. Conclusion: These results suggest that intensive supervised CR significantly improved exercise capacity, which may be attributable to an adaptive response involving more efficient oxidative metabolites or the increased capacity of endogenous anti-oxidative systems in pa -tients with cardiovascular diseases.
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