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RISS 인기검색어
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- 저자 : Yulan Gao (검색결과 3 건)
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Yulan Gao,Xiangchen Fang,Zhenmin Cheng,Liming Xu,Zhenhui Lu,Shanda Wang 한국공업화학회 2015 Journal of Industrial and Engineering Chemistry Vol.26 No.-
An ex-situ presulfurization technology for transforming the metal oxides of hydrotreating catalyst to the corresponding metal oxy-sulfides was developed, involving pre-dispersion of an organo-nitrogen substance onto catalyst and a subsequent multi-step heat treatment. The inherence of exothermic effect involved in the ex situ pre-sulfurized catalyst fabrication and activation, and particularly the relationship between the exothermic effect and the surface property of catalyst were investigated. The results indicated that both the preparation parameters and the operating conditions can have effects on the exothermic behavior and surface state of the catalyst. The information obtained in the current study is useful for optimizing the EPRES process, essential for hydrotreating catalyst and its application.
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Melatonin attenuates microbiota dysbiosis of jejunum in short-term sleep deprived mice
Gao Ting,Wang Zixu,Cao Jing,Dong Yulan,Chen Yaoxing 한국미생물학회 2020 The journal of microbiology Vol.58 No.7
Our study demonstrated that sleep deprivation resulted in homeostasis disorder of colon. Our study goes deeper into the positive effects of melatonin on small intestinal microbiota disorder caused by sleep deprivation. We successfully established a multiplatform 72 h sleep deprivation mouse model with or without melatonin supplementation, and analyzed the change of small intestinal microbiota using high-throughput sequencing of the 16S rRNA. We found melatonin supplementation suppressed the decrease of plasma melatonin level in sleep deprivation mice. Meanwhile, melatonin supplementation improved significantly the reduction in OTU numbers and the diversity and richness of jejunal microbiota and the abundance of Bacteroidaeae and Prevotellaceae, as well as an increase in the Firmicutes-to-Bacteroidetes ratio and the content of Moraxellaceae and Aeromonadaceae in the jejunum of sleep deprived-mice. Moreover, melatonin supplementation reversed the change of metabolic pathway in sleep deprived-mice, including metabolism, signal transduction mechanisms and transcription etc, which were related to intestinal health. Furthermore, melatonin supplementation inverted the sleep deprivation-induced a decline of anti-inflammatory cytokines (IL-22) and an increase of the ROS and proinflammatory cytokines (IL-17) in jejunum. These findings suggested that melatonin, similar to a probiotics agent, can reverse sleep deprivation-induced small intestinal microbiota disorder by suppressing oxidative stress and inflammation response.
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Role of melatonin in murine “restraint stress”-induced dysfunction of colonic microbiota
Lin Rutao,Wang Zixu,Cao Jing,Gao Ting,Dong Yulan,Chen Yaoxing 한국미생물학회 2021 The journal of microbiology Vol.59 No.5
Intestinal diseases caused by physiological stress have become a severe public health threat worldwide. Disturbances in the gut microbiota-host relationship have been associated with irritable bowel disease (IBD), while melatonin (MT) has antiinflammatory and antioxidant effects. The objective of this study was to investigate the mechanisms by which MT-mediated protection mitigated stress-induced intestinal microbiota dysbiosis and inflammation. We successfully established a murine restraint stress model with and without MT supplementation. Mice subjected to restraint stress had significantly elevated corticosterone (CORT) levels, decreased MT levels in their plasma, elevated colonic ROS levels and increased bacterial abundance, including Bacteroides and Tyzzerella, in their colon tract, which led to elevated expression of Toll-like receptor (TLR) 2/4, p-P65 and p-IκB. In contrast, supplementation with 20 mg/kg MT reversed the elevation of the plasma CORT levels, downregulated the colon ROS levels and inhibited the changes in the intestinal microbiota induced by restraint stress. These effects, in turn, inhibited the activities of TLR2 and TLR4, p-P65 and p-IκB, and decreased the inflammatory reaction induced by restraint stress. Our results suggested that MT may mitigate “restraint stress”-induced colonic microbiota dysbiosis and intestinal inflammation by inhibiting the activation of the NF-κB pathway.
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