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RISS 인기검색어
- 검색키워드
- 저자 : Yujing Lu (검색결과 3 건)
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Lu Gao,Xuehua Pu,Yujing Huang,Jing Huang 한국유전학회 2019 Genes & Genomics Vol.41 No.6
Objectives Neuropathic pain (NP) is one of the main challenges towards NP syndrome treatment. miR-340-5p exhibit different expression levels in NP models. Its effects on NP remained unclear. The objective of this study was to explore the potential regulation mechanisms of miR-340-5p in NP. Methods Rat model of chronic constriction injury (CCI) was established to induce NP in vivo. NP levels were assessed using mechanical withdrawal threshold (MWT). The inflammation response in CCI rats were determined by HE staining and ELISA assay. The target genes of miR-340-5p were verified by luciferase report assays. Results In CCI rats, level of miR-340-5p was down-regulated both in spinal cord tissues and isolated microglial cells. Paw withdrawal threshold (PWT) and paw withdrawal latency (PWL) were decreased in CCI rats, which were restored upon miR-340-5p overexpression. miR-340-5p overexpression also decreased inflammation as well as expression levels of COX- 2, IL-1β, TNF-α and IL-6 in CCI rats. Luciferase report assays revealed Rap1A was a target gene of miR-340-5p in the experimental model. Elevated miR-340-5p decreased Rap1A expression level in vitro and in vivo. Overexpression of Rap1A protein restored expression levels of COX-2, IL-1β, TNF-α and IL-6, reduced the PWT and PWL and increased inflammation response in CCI rats. Conclusion miR-340-5p alleviated CCI-induced NP by targeting Rap1A. miR-340-5p and Rap1A may be the potential treatment targets for NP therapeutics.
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Huaqian Wang,Dongli Li,Zhi-Yun Du,Mou-Tuan Huang,Xiaoxing Cui,Yujing Lu,Chenyue Li,Swee Lian Woo,Allan H Conney,Xi Zheng,Kun Zhang 한국식품과학회 2015 Food Science and Biotechnology Vol.24 No.3
Stems and leaves of Acanthopanax trifoliatus (L) Merr (AT) are commonly used as an edible vegetable in China. The scientific basis of antioxidant and antiinflammatory activities of AT was investigated. The polyphenol contents and free radical scavenging activities of AT ethanol extracts (EAT) were determined. Chlorogenic acid, isochlorogenic acid A, isochlorogenic acid C, and rutin were identified as major components in EAT. LPS-induced NO production in RAW264.7 cells was decreased significantly (p<0.05) after EAT treatment, compared with controls. In vivo studies indicated that EAT had more activity than chlorogenic acid per mg of dry weight for inhibition of TPA-induced ear edema. TPA-induced increases in cytokine production (TNF-α, IL-6, MMP-9, and TIMP-1) were significantly (p<0.05) reduced by EAT treatment, compared with controls. EAT exerts anti-inflammatory activities probably due, at least in part, to chlorogenic acid.
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Zhichao Yang,Shuqiang Liu,Jingjing Li,Gaihong Wu,Man Zhang,Fu Li,Lu Jia,Yujing Zhang,Huimin Li,Xia Liu,Jingjing Zhao,Huiqin Zhang,Shiyu Li 한국섬유공학회 2023 Fibers and polymers Vol.24 No.12
Polylactic acid (PLA) surgical suture is considered to be one of the most ideal materials for tissue closure due to its rich raw materials and excellent biological properties. However, surgical sutures face great challenges due to problems such as wound infection and tissue reaction in practical applications. In order to improve the clinical applicability of surgical sutures, we constructed a new drug-loading system for core-spun surgical sutures. The shell was composed of nanofibrous membranes composed of polyglycolic acid (PGA) and polycaprolactone (PCL) and ciprofloxacin (CIP) antibacterial drugs, and the core layer adopts PLA filament. By adjusting the composition ratio of PGA and PCL in the shell, a new mode of regulating the release rate and release cycle of the suture was constructed. According to different wound healing time, different drug release cycles of surgical suture were selected. In the study, the structure of the core-spun yarn can be clearly observed by scanning electron microscope, the higher the shell PGA content and drug loading, the faster the drug release rate. When the carrier ratio PGA/PCL was 80/20 and the drug loading was 3%, the drug release rate was the fastest and the drug release was high; finally, antibacterial experiments showed that the suture had excellent antibacterial effect and could effectively kill Staphylococcus aureus and Escherichia coli. The successful preparation of core-spun yarn surgical suture provides a new idea for the study of new antibacterial surgical suture.
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