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Kang, Yujin,Lee, Jinyong,Kim, Jisoo,Oh, Yeeun,Kim, Dogeun,Lee, Jungyun,Lim, Sangyong,Jo, Kyubong The Royal Society of Chemistry 2016 The Analyst Vol.141 No.14
<P>Consumption of alcohol injures DNA, and such damage is considered to be a primary cause for the development of cancer and many other diseases essentially due to reactive oxygen species generated from alcohol. To sensitively detect alcohol-induced DNA lesions in a biological system, we introduced a novel analytical platform for visualization of single genomic DNA molecules using E. coli. By fluorescently labelling the DNA lesions, our approach demonstrated, with the highest sensitivity, that we could count the number of DNA lesions induced by alcohol metabolism in a single bacterial cell. Moreover, our results showed a linear relationship between ethanol concentration and the number of DNA lesions: 0.88 lesions per 1% ethanol. Using this approach, we quantitatively analysed the DNA damage induced by exposure to alcoholic beverages such as beer (5% ethanol), rice wine (13%), soju (20%), and whisky (40%).</P>
Yujin Kang,Seong Jin Chang,Sumin Kim 한국목재공학회 2016 목재공학 Vol.44 No.2
The insulation of a building envelope influences the hygrothermal performance as well as the thermal performance of the building. While most of Korean wood frame houses have an interior insulation system, the exterior insulation system with high thermal performance has recently been applied. While it can be effective in energy savings for better insulation performance, without consideration of the moisture, condensation and mould growth can occur. Therefore, in this study, hygrothermal behaviour, water content, and mould growth were analyzed using hygrothermal simulation of an exterior wall of a wood frame house with which the interior insulation and exterior insulation systems were applied. The wall layer included Wall A (Interior insulation) and Wall B (Exterior insulation). The U-values were identified as 0.173 and 0.157 W/m2K, respectively. The total water content and OSB absolute water content of Wall A were confirmed to be higher than those of Wall B, but the absolute water content did not exceed the reference value of 20%. The moisture content of the two walls was determined to be stable in the selected areas. However, mould growth risk analysis confirmed that both Wall A and Wall B were at risk of mould growth. It was confirmed that as the indoor setting temperature decreased, the mould index and growth rate in the same area increased. Therefore, the mould growth risk was affected more by indoor and outdoor climate conditions than by the position of the insulation. Consequently, the thermal performance of Wall B was superior to that of Wall A but the hygrothermal performances were confirmed to be similar.
Kang, Yujin,Shin, Wonhyeop,Yun, Jiweon,Kim, Yonghwan,Song, Youngkeun National Institute of Ecology 2022 Proceedings of NIE Vol.3 No.1
Species distribution models are a useful tool for predicting future distribution and establishing a preemptive response of invasive species. However, few studies considered the possibility of habitat for the aquatic organism and the number of target sites was relatively small compared to the area. Environmental DNA (eDNA) is the emerging tool as the methodology obtaining the bulk of species presence data with high detectability. Thus, this study applied eDNA survey results of Micropterus salmoides and Lepomis macrochirus to species distribution modeling by seasons in the Anyang stream network. Maximum Entropy (MaxEnt) model evaluated that both species extended potential distribution area in October compared to July from 89.1% (12,110,675 m<sup>2</sup>) to 99.3% (13,625,525 m<sup>2</sup>) for M. salmoides and 76.6% (10,407,350 m<sup>2</sup>) to 100% (13,724,225 m<sup>2</sup>) for L. macrochirus. The prediction value by streams was varied according to species and seasons. Also, models elucidate the significant environmental variables which affect the distribution by seasons and species. Our results identified the potential of eDNA methodology as a way to retrieve species data effectively and use data for building a model.
Kang, Yujin,Cho, Carol,Lee, Kyung Suk,Song, Ji-Joon,Lee, Ja Yil Korean Society for Molecular and Cellular Biology 2021 Molecules and cells Vol.44 No.2
Chromatin dynamics is essential for maintaining genomic integrity and regulating gene expression. Conserved bromodomain-containing AAA+ ATPases play important roles in nucleosome organization as histone chaperones. Recently, the high-resolution cryo-electron microscopy structures of Schizosaccharomyces pombe Abo1 revealed that it forms a hexameric ring and undergoes a conformational change upon ATP hydrolysis. In addition, single-molecule imaging demonstrated that Abo1 loads H3-H4 histones onto DNA in an ATP hydrolysis-dependent manner. However, the molecular mechanism by which Abo1 loads histones remains unknown. Here, we investigated the details concerning Abo1-mediated histone loading onto DNA and the Abo1-DNA interaction using single-molecule imaging techniques and biochemical assays. We show that Abo1 does not load H2A-H2B histones. Interestingly, Abo1 deposits multiple copies of H3-H4 histones as the DNA length increases and requires at least 80 bp DNA. Unexpectedly, Abo1 weakly binds DNA regardless of ATP, and neither histone nor DNA stimulates the ATP hydrolysis activity of Abo1. Based on our results, we propose an allosteric communication model in which the ATP hydrolysis of Abo1 changes the configuration of histones to facilitate their deposition onto DNA.
Kang, Changku,Shin, Yujin,Kim, Ye Eun,Moon, Jongyeol,Kang, Jae Yeon,Jang, Yikweon The Ecological Society of Korea 2016 Journal of Ecology and Environment Vol.39 No.1
Declines in amphibian populations are occurring worldwide, and have been attributed to many factors, including anthropogenic environmental changes. One of the ramifications of such declines is abnormalities in many amphibian species. A strong association has been detected between human activities and abnormalities in amphibian populations, but studies on this association are largely focused on lentic species. In this study, it was analyzed whether the degree of local human activity was associated with the rate of abnormalities in Bombina orientalis which inhabited lotic environments. We found that the proportions of abnormalities in wild populations of B. orientalis increased, when i) the closest human land use was located within 100 m from the frogs' habitat, and ii) the proportion of human land use within a 300-m radius was high. Our findings suggest that human activity has a negative impact on the fitness of nearby amphibian populations, and that wild populations very close to human-induced disturbance are affected.
Kang, Yujin,Chang, Seong Jin,Kim, Sumin Elsevier 2018 Energy and buildings Vol.165 No.-
<P><B>Abstract</B></P> <P>Gypsum board as a wall and ceiling finishing material can be used to reduce building energy consumption. To optimally use gypsum board as building material, methods are needed to reduce mold and condensation that frequently found on the material and inner surfaces of the board. The influence of gypsum board on hygrothermal behavior of building needs to be confirmed first. The objective of this study was to reduce gypsum boards’ thermal conductivity and improve their moisture properties. Their effect on the hygrothermal behavior and performance of buildings were then evaluated. Specifically, gypsum board was applied to a concrete wall in this study. Porous materials such as expanded vermiculite (EV), expanded perlite (EP), and three xGnP of different surface areas (C-300, C-500 and C-750) were used to improve the thermal and moisture performance of the gypsum board. Gypsum boards’ density, thermal conductivity, water vapor resistance factor, and water content of gypsum board by relative humidity were then evaluated. The influence of hygrothermal behavior of walls when gypsum boards adding porous materials were used as interior finishing materials on concrete wall were then examined.</P> <P><B>Highlights</B></P> <P> <UL> <LI> The gypsum boards containing porous materials was prepared. </LI> <LI> Thermal conductivity reduces when the porous materials is mixed. </LI> <LI> Carbon nano-materials have the effect of containing a larger amount of moisture. </LI> <LI> The gypsum board mixed with the carbon nano-material improves heat and moisture performance. </LI> <LI> It is possible to reduce the risk of mold growth on the interior surface. </LI> </UL> </P>