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- 저자 : Yuji Shibasaki (검색결과 4 건)
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Lee, Sueun,Saito, Kyohei,Lee, Hye-Ra,Lee, Min Jae,Shibasaki, Yuji,Oishi, Yoshiyuki,Kim, Byeong-Su American ChemicalSociety 2012 Biomacromolecules Vol.13 No.4
<P>We report the synthesis of a well-defined hyperbrancheddoublehydrophilic block copolymer of poly(ethylene oxide)-<I>hyperbranched</I>-polyglycerol (PEO-<I>hb</I>-PG) to develop an efficientdrug delivery system. In specific, we demonstrate the hyperbranchedPEO-<I>hb</I>-PG can form a self-assembled micellar structureon conjugation with the hydrophobic anticancer agent doxorubicin,which is linked to the polymer by pH-sensitive hydrazone bonds, resultingin a pH-responsive controlled release of doxorubicin. Dynamic lightscattering, atomic force microscopy, and transmission electron microscopydemonstrated successful formation of the spherical core–shelltype micelles with an average size of about 200 nm. Moreover, thepH-responsive release of doxorubicin and in vitro cytotoxicity studiesrevealed the controlled stimuli-responsive drug delivery system desirablefor enhanced efficiency. Benefiting from many desirable features ofhyperbranched double hydrophilic block copolymers such as enhancedbiocompatibility, increased water solubility, and drug loading efficiencyas well as improved clearance of the polymer after drug release, webelieve that double hydrophilic block copolymer will provide a versatileplatform to develop excellent drug delivery systems for effectivetreatment of cancer.</P><P><B>Graphic Abstract</B> <IMG SRC='http://pubs.acs.org/appl/literatum/publisher/achs/journals/content/bomaf6/2012/bomaf6.2012.13.issue-4/bm300151m/production/images/medium/bm-2012-00151m_0006.gif'></P><P><A href='http://pubs.acs.org/doi/suppl/10.1021/bm300151m'>ACS Electronic Supporting Info</A></P>
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Oikawa, Yurie,Lee, Sueun,Kim, Do Hyung,Kang, Dae Hwan,Kim, Byeong-Su,Saito, Kyohei,Sasaki, Shigeko,Oishi, Yoshiyuki,Shibasaki, Yuji American Chemical Society 2013 Biomacromolecules Vol.14 No.7
<P>This paper describes the one-pot synthesis of a polyglycidol (PG)-based polymer, poly(ethoxyethyl glycidyl ether) (PEEGE)-<I>b</I>-[<I>hyperbranched</I> polyglycerol (<I>hb</I>PG)-<I>co</I>-PEEGE]<SUB><I>x</I>/<I>y</I></SUB>, its micelle formulation, and the ability to encapsulate a model therapeutic molecule. Amphiphilic block copolymers were prepared by the sequential addition of ethoxyethyl glycidyl ether (EEGE) to glycidol. The composition of the block copolymers varied from 62:38 to 92:8. Block copolymers with composition <I>x</I>:<I>y</I> ≥ 66:34 were soluble only in organic solvents. Micelles were formulated by injection of deionized water into a tetrahydrofuran block copolymer solution with or without pyrene as a model hydrophobic molecule. The critical micelle concentration was 18.2–30.9 mg/L, and the micelle size was 100–250 nm. The pyrene-containing micelle rapidly collapsed on acidic exposure, allowing conversion of hydrophobic PEEGE to hydrophilic PG, thus, facilitating the release of the encapsulated pyrene. Cytotoxicity data showed high biocompatibility of PG-based block copolymers, suggesting their potential as a drug delivery carrier.</P><P><B>Graphic Abstract</B> <IMG SRC='http://pubs.acs.org/appl/literatum/publisher/achs/journals/content/bomaf6/2013/bomaf6.2013.14.issue-7/bm400275w/production/images/medium/bm-2013-00275w_0009.gif'></P><P><A href='http://pubs.acs.org/doi/suppl/10.1021/bm400275w'>ACS Electronic Supporting Info</A></P>
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