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- 저자 : Yu Chenxiao (검색결과 2 건)
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Shaking Table Study of the Three-Dimensional Isolation of a Cylindrical Reticulated Shell
Gui-bo Nie,Chenxiao Zhang,Zhi-yong Wang,Yu-jie Shi 한국강구조학회 2022 International Journal of Steel Structures Vol.22 No.2
A set of shaking table tests were conducted to investigate the dynamic response characteristics of a single-layer cylindrical reticulated shell (SLCRS) with three-dimensional column-top seismic isolation. The infl uence of infi lled wall on the seismic and isolation performance of the structure was investigated. The dynamic response characteristics of structures with and without seismic isolation were compared to investigate the eff ects of seismic isolation. The dynamic responses of lower-frame models with and without an infi lled wall were also compared to investigate the eff ects of the infi lled wall on the seismic isolation. Results show that the three-dimensional column-top seismic isolation improved the seismic safety of infi lled wall. At the same time, the three-dimensional column-top isolation bearing can signifi cantly reduce the acceleration and stress of the structure. The excellent isolation performance of the three-dimensional isolation bearing promises outstanding application prospects for this isolation bearing in highly seismic areas. In addition, under a small earthquake, the acceleration of the second fl oor with the isolation bearing was unfavorably magnifi ed. Therefore, the seismic performance of the acceleration-sensitive nonstructural components should be improved when the three-dimensional column-top seismic isolation is applied in the areas of low seismicity. The test data and conclusions obtained in the present study can provide theoretical and technical support for the actual engineering application of such three-dimensional seismic isolation bearings.
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Downregulation of HuR Inhibits the Progression of Esophageal Cancer through Interleukin-18
Xu Xiaohui,Song Cheng,Chen Zhihua,Yu Chenxiao,Wang Yi,Tang Yiting,Luo Judong 대한암학회 2018 Cancer Research and Treatment Vol.50 No.1
Purpose The purpose of this study was to investigate the effect of human antigen R (HuR) downregulation and the potential target genes of HuR on the progression of esophageal squamous cell carcinoma (ESCC). Materials and Methods In this study, a proteomics assay was used to detect the expression of proteins after HuR downregulation, and a luciferase assay was used to detect the potential presence of a HuR binding site on the 3’-untranslated region (3'-UTR) of interleukin 18 (IL-18). In addition, colony formation assay, MTT, EdU incorporation assay, Western blot, flow cytometry, immunohistochemistry, transwell invasion assay, and wound healing assay were used. Results In the present study, we found that the expression of both HuR protein and mRNA levels were higher in tumor tissues than in the adjacent tissues. HuR downregulation significantly suppressed cell proliferation. In addition, the metastasis of esophageal cancer cells was inhibited, while the expression of E-cadherin was increased and the expression of matrix metalloproteinase (MMP) 2, MMP9, and vimentin was decreased after HuR knockdown. Moreover, silencing of HuR disturbed the cell cycle of ESCC cells mainly by inducing G1 arrest. Furthermore, proteomics analysis showed that downregulation of HuR in TE-1 cells resulted in 100 upregulated and 122 downregulated proteins, including IL-18 as a significantly upregulated protein. The expression of IL-18 was inversely regulated by HuR. IL-18 expression was decreased in ESCC tissues, and exogenous IL-18 significantly inhibited the proliferation and metastasis of ESCC cells. The 3'-UTR of IL-18 harbored a HuR binding site, as shown by an in vitro luciferase assay. Conclusion HuR plays an important role in the progression of esophageal carcinoma by targeting IL-18, which may be a potential therapeutic target for the treatment of ESCC.
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