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RISS 인기검색어
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- 저자 : Yong-ze LU (검색결과 2 건)
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Mahdi Hassan,Guangcan Zhu,Yong-ze LU,Ali Hamoud AL-Falahi,Yuan LU,Shan Huang,Ziren Wan 대한환경공학회 2021 Environmental Engineering Research Vol.26 No.1
In this review, antibiotics are considered an emerging pollutant that has drawn worldwide attention in recent years. Therefore, the effective removal of antibiotic contaminants has become a hot issue in the field of environmental research. Most antibiotics applied to humans eventually enter municipal Wastewater Treatment Plants (WWTPs), because there are no appropriate commercially available pretreatment techniques. However, increasing anthropogenic activities, the high demand for animal-protein in developing countries as a nutritional alternative, and the extensive usage of antibiotics are mainly responsible for the persistence of antibiotic pollutants. One of the serious concerns regarding the presence of antibiotics in water and their potential role in exacerbating the emergence of antibiotics-resistance bacteria (ARB) and antibiotics-resistance genes (ARGs). In recent years, bioelectrochemical technologies are found promising for suppressing antibiotic contaminants through microbial metabolism and electrochemical redox reactions. Therefore, this review provides up-to-date insight research on bioelectrochemical systems (BESs), which improves the removal of the antibiotic in an efficient way. The focus of this review has been on the environmental sources of antibiotics, their health effects and possible degradation pathways, bacterial-antibiotics resistance mechanisms, and treatment of antibiotic-contained water using BES technology.
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Zhou Meng-jiao,Yang Jia-jie,Ma Ting-yao,Feng Ge-xuan,Wang Xue-lian,Wang Li-Yong,Ge Yu-ze,Gao Ran,Hong-liang Liu,Shan Lin,Kong Lu,Chen Xiao-hong 생화학분자생물학회 2023 Experimental and molecular medicine Vol.55 No.-
MYB-NFIB fusion and NOTCH1 mutation are common hallmark genetic events in salivary gland adenoid cystic carcinoma (SACC). However, abnormal expression of MYB and NOTCH1 is also observed in patients without MYB-NFIB fusion and NOTCH1 mutation. Here, we explore in-depth the molecular mechanisms of lung metastasis through single-cell RNA sequencing (scRNA-seq) and exome target capture sequencing in two SACC patients without MYB-NFIB fusion and NOTCH1 mutation. Twenty-five types of cells in primary and metastatic tissues were identified via Seurat clustering and categorized into four main stages ranging from near-normal to cancer-based on the abundance of each cell cluster in normal tissue. In this context, we identified the Notch signaling pathway enrichment in almost all cancer cells; RNA velocity, trajectory, and sub-clustering analyses were performed to deeply investigate cancer progenitor-like cell clusters in primary tumor-associated lung metastases, and signature genes of progenitor-like cells were enriched in the “MYC_TARGETS_V2” gene set. In vitro, we detected the NICD1-MYB-MYC complex by co-immunoprecipitation (Co-IP) and incidentally identified retinoic acid (RA) as an endogenous antagonist of genes in the “MYC_TARGETS_V2” gene set. Following this, we confirmed that all-trans retinoic acid (ATRA) suppresses the lung metastasis of SACC by correcting erroneous cell differentiation mainly caused by aberrant NOTCH1 or MYB expression. Bioinformatic, RNA-seq, and immunohistochemical (IHC) analyses of primary tissues and metastatic lung tissues from patients with SACC suggested that RA system insufficiency partially promotes lung metastasis. These findings imply the value of the RA system in diagnosis and treatment.
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