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IN SITU UNZIPPING OF CARBON NANOTUBES TO FORM GRAPHENE NANORIBBONS
YONG-SHENG ZHOU,PAN JIN,TENG GUO,YING-CHUN ZHU,GAO-HUI DU,BING-SHE XU 성균관대학교(자연과학캠퍼스) 성균나노과학기술원 2014 NANO Vol.9 No.1
We report the one step facile synthesis of graphene nanoribbons (GNRs) by unzipping carbonnanotubes (CNTs) from glucose (C 6 H 12 O 6 ) precursor, using a simple chemical vapor depositionmethod. Some nanotubes are partially cut resulting in a GNR – CNT hybrid whereas others arefully cut to form GNRs. The average length of GNRs achieved by this method is typically in therange of 1 – 10 ? m. The formation of GNRs is ascribed to the in situ oxygen-driven unzipping ofCNTs. The process is free from aggressive oxidants and utilizes the in situ unzipping. Thismethod o®ers an alternative approach for making GNRs, compared to previously used techniquesto synthesize GNRs.
Tanshinone IIA Reverses the Malignant Phenotype of SGC7901 Gastric Cancer Cells
Xu, Min,Cao, Fa-Le,Li, Nai-Yi,Liu, Yong-Qiang,Li, Yan-Peng,Lv, Chun-Lei Asian Pacific Journal of Cancer Prevention 2013 Asian Pacific journal of cancer prevention Vol.14 No.1
Backgrounds: Tanshinone IIA (TIIA), a phenanthrenequinone derivative extracted from Salvia miltiorrhiza BUNGE, has been reported to be a natural anti-cancer agent in a variety of tumor cells. However, the effect of TIIA on gastric cancer cells remains unknown. In the present study, we investigated the influence of TIIA on the malignant phenotype of SGC7901 gastric cancer cells. Methods: Cells cultured in vitro were treated with TIIA (0, 1, 5, $10{\mu}g/ml$) and after incubation for different periods, cell proliferation was measured by MTT method and cell apoptosis and cell cycling were assessed by flow cytometry (FCM). The sensitivity of SGC7901 gastric cancer cells to anticancer chemotherapy was investigated with the MTT method, while cell migration and invasion were examined by wound-healing and transwell assays, respectively. Results: TIIA (1, 5, $10{\mu}g/ml$) exerted powerful inhibitory effects on cell proliferation (P < 0.05, and P < 0.01), and this effect was time- and dose-dependent. FCM results showed that TIIA induced apoptosis of SGC7901 cells, reduced the number of cells in S phase and increased those in G0/G1 phase. TIIA also significantly increased the sensitivity of SGC7901 gastric cancer cells to ADR and Fu. Moreover, wound-healing and transwell assays showed that TIIA markedly decreased migratory and invasive abilities of SGC7901 cells. Conclusions: TIIA can reverse the malignant phenotype of SGC7901 gastric cancer cells, indicating that it may be a promising therapeutic agent.
Xu, Chun-Sheng,Zheng, Jian-Yong,Zhang, Hai-Long,Zhao, Hua-Dong,Zhang, Jing,Wu, Guo-Qiang,Wu, Lin,Wang, Qing,Wang, Wei-Zhong,Zhang, Jian Asian Pacific Journal of Cancer Prevention 2012 Asian Pacific journal of cancer prevention Vol.13 No.7
Esophageal carcinoma (EC) is one of the most aggressive cancers with a poor prognosis. Understanding the molecular mechanisms underlying esophageal cancer progression is a high priority for improved EC diagnosis and prognosis. Recently, MSP58 was shown to behave as an oncogene in colorectal carcinomas and gliomas. However, little is known about its function in esophageal carcinomas. We therefore examined the effects of MSP58 knockdown on the growth of esophageal squamous cell carcinoma (ESCC) cells in vitro and in vivo in order to gain a better understanding of its potential as a tumor therapeutic target. We employed lentiviral-mediated small hairpin RNA (shRNA) to knock down the expression of MSP58 in the ESCC cell lines Eca-109 and EC9706 and demonstrated inhibition of ESCC cell proliferation and colony formation in vitro. Furthermore, flow cytometry and western blot analyses revealed that MSP58 depletion induced cell cycle arrest by regulating the expression of P21, CDK4 and cyclin D1. Notably, the downregulation of MSP58 significantly inhibited the growth of ESCC xenografts in nude mice. Our results suggest that MSP58 may play an important role in ESCC progression.
Pyrophosphate-triggered nanoaggregates with aggregation-induced emission
Li, Chun-Tao,Xu, You-Liang,Yang, Jian-Gong,Chen, Yong,Kim, Hyeong Seok,Cao, Qian-Yong,Kim, Jong Seung Elsevier Sequoia 2017 Sensors and actuators. B Chemical Vol.251 No.-
<P><B>Abstract</B></P> <P>A novel tetraphenylethene-based probe bearing bis-imidazolium anion donors is herein reported for pyrophosphate anion recognition. This probe can self-assemble finite, small sphere nanoaggregates with very weak emission in aqueous solution, and changes into large rod-like nanoaggregates with strong aggregation-induced emission upon binding with the pyrophosphate anion.</P> <P><B>Highlights</B></P> <P> <UL> <LI> A bis-imidazolium functionalized tetraphenylethene probe was prepared. </LI> <LI> This probe self-assemble finite small sphere nanoaggregates in aqueous solution. </LI> <LI> The probe can recognize pyrophosphate anion with strong aggregation-induced emission. </LI> <LI> The probe/pyrophosphate assembly can fluorescence assay alkaline phosphatase. </LI> </UL> </P> <P><B>Graphical abstract</B></P> <P>A novel nanoaggregates for recognition of pyrophosphate anion with aggregation-induced emission in pure aqueous solution is introduced.</P> <P>[DISPLAY OMISSION]</P>
Preparation of HMX by Catalytic Nitrolysis of DPT in AIL-N_2O_5-HNO_3 System
Zhi-yong He,Jun Luo,Chun-xu Lü,Ping Wang,Rong Xu,Jin-shan Li 대한화학회 2011 Bulletin of the Korean Chemical Society Vol.32 No.8
Direct nitrolysis of 3,7-dinitro-1,3,5,7-tetraazabicyclo[3,3,1]nonane (DPT) is a feasible way to synthesize HMX, and it has multiple practical applications. In this paper, a new nitrolysis process involving the use of an N_2O_5-HNO_3 system catalyzed by acidic ionic liquids (AILs) was developed. The results show that [Et_3NH]TsO was the best catalyst among the 28 AILs used and that HMX was formed at a higher yield of 61%, compared to 45% without any AIL. Moreover, with the addition of N_2O_5, the yield was further increased to a maximum value of 69%. The AILs were also efficiently recovered by simple extractions without any apparent loss of catalytic activity, even after five runs.
DE XU, HONG,CHO, SOON-CHANG,BANG, MI-AE,BAE, CHUN-SIK,CHOI, YEONSHIK,LI, YONG-CHUN,LIM, SEUNG-KIL,SHIM, JAEGAL,PARK, DAE-HUN D.A. Spandidos 2015 International journal of oncology Vol.46 No.6
<P>The World Health Organization (WHO) has reported that cancer is one of the most prevalent diseases and a leading cause of death worldwide. Many anticancer drug development studies have been pursued over the last few decades and several viable drugs have been discovered, such as paclitaxel, topotecan and irinotecan. Previously, our research group uncovered the cytocidal and cytostatic effects of the plant <I>Stephania delavayi</I> Diels. In this study, we determined the active chemical to be 6,7-di-O-acetylsinococuline (FK-3000). The FK-3000 half maximal inhibitory concentration (IC<SUB>50</SUB>) in MDA-MB-231 breast carcinoma cells at 48 h was 0.52 μg/ml and it induced apoptosis in a dose- and time-dependent manner. FK-3000 suppressed NF-κB nuclear translocation, decreased NF-κB phosphorylation, and decreased COX-2 protein expression. MDA-MB-231 xenografted mice were treated with FK-3000, Taxol, or their combination for 21 days. The tumor size was smallest in the co-treatment group, indicating that FK-3000 may have a synergistic effect with Taxol. FK-3000 treatment showed no adverse effects on blood cell counts, serum protein levels, or pathology. These studies demonstrate that FK-3000, isolated from <I>S. delavayi</I> Diels., is a promising, pathway-specific anticancer agent that exhibits low toxicity.</P>
일문전(Stephania delavayi Diels.) 메탄올, 부탄올, 에틸아세테이트 분획물의 항산화 및 세포증식억제 효과
이용순(Yong-Chun Li),김경희(Kyoung-Hee Kim),서홍덕(Hong-De Xu),박대훈(Dae-Hun Park),최연식(Yeon Shik Choi),황혜림(Hye-Rim Hwang),이민재(Min-Jae Lee),최종진(Jong-Jin Choi),권명상(Myung-Sang Kwon),육홍선(Hong-Sun Yook) 한국식품영양과학회 2009 한국식품영양과학회지 Vol.38 No.3
본 연구에서는 중국에서 급성 위장염에 대한 약제로 사용되어 오던 일문전의 메탄올 추출물을 이용하여 물, 에틸 아세테이트, 부탄올 층으로 분획한 뒤 항산화 활성과 항암활성을 측정하였다. DPPH 라디칼 소거능은 1,000 ㎍/mL 농도에서 부탄올(75.23%)>메탄올(68.11%)>에틸아세테이(63.58%)>물(50.13%) 순으로 나타났으며 환원력의 경우 용매 분획물의 농도가 증가함에 따라 환원력이 증가하는 경향을 나타내었다. DPPH 라디칼 소거능 및 환원력 모두 부탄올 분획층에서 좋은 활성을 나타내었다. 항암활성 측정결과 메탄올 추출물과 부탄올 분획물, 에틸 아세테이트 분획물에서 MDA-MB-231 cell과 MCF-7 cell에 대한 세포증식억제효과를 나타내었다. 이상의 결과에서 일문전의 용매 분획물은 항암 후보물질로의 가능성이 있을 것으로 사료된다. Stephania delavayi Diels. (S. delavayi Diels.) has been used as a drug for pain-relieving and acute gastroenteritis treatment in China. Because the major therapeutic mechanism of anti-inflammatory drug is to inhibit the cyclooxygenase (COX)-2 and because COX-2 proteins inhibit apoptosis, COX-2 inhibitor has been thought as the anticancer drug candidate. For this reason, we examined S. delavayi Diels. as an anticancer drug. S. delavayi Diels. was fractionated with methanol and then partitioned with ethyl acetate, n-butanol and water. The antioxidant activity was evaluated by 1,1-diphenyl-2-picrylhydrazyl (DPPH) radical scavenging activity and reducing power. DPPH radical scavenging activities of the crude fractions at the concentration of 1,000 ㎍/mL were 75.23% (n-butanol), 68.11% (methanol), 63.58% (ethyl acetate), and 50.13% (water). The reducing power increased according to the concentration in dose-dependent manner. Also, when the antiproliferation effects of each fraction against human breast cancer cell-lines MDA-MB-231 and MCF-7 were examined, methanol extract, n-butanol fraction and ethyl acetate fraction exhibited cell proliferative inhibition effects in both cell-lines whereas water fraction did not. Among the crude fractions, the n-butanol fraction exhibited the most potent anti-proliferation effect. In conclusion, fractions from S. delavayi Diels. are promising anticancer drug candidates.