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- 저자 : Yingjun Zhao (검색결과 4 건)
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Intracellular trafficking of TREM2 is regulated by presenilin 1
Yingjun Zhao,Xiaoguang Li,Timothy Huang,Lu-lin Jiang,Zhenqiu Tan,Muxian Zhang,Irene Han-Juo Cheng,Xin Wang,Guojun Bu,Yun-wu Zhang,Qi Wang,Huaxi Xu 생화학분자생물학회 2017 Experimental and molecular medicine Vol.49 No.-
Genetic mutations in triggering receptor expressed on myeloid cells 2 (TREM2) have been linked to a variety of neurodegenerative diseases including Alzheimer’s disease, amyotrophic lateral sclerosis, frontotemporal dementia and Parkinson’s disease. In the brain, TREM2 is highly expressed on the cell surface of microglia, where it can transduce signals to regulate microglial functions such as phagocytosis. To date, mechanisms underlying intracellular trafficking of TREM2 remain elusive. Mutations in the presenilin 1 (PS1) catalytic subunit of the γ-secretase complex have been associated with increased generation of the amyloidogenic Aβ (amyloid-β) 42 peptide through cleavage of the Aβ precursor amyloid precursor protein. Here we found that TREM2 interacts with PS1 in a manner independent of γ-secretase activity. Mutations in TREM2 alter its subcellular localization and affects its interaction with PS1. Upregulation of PS1 reduces, whereas downregulation of PS1 increases, steady-state levels of cell surface TREM2. Furthermore, PS1 overexpression results in attenuated phagocytic uptake of Aβ by microglia, which is reversed by TREM2 overexpression. Our data indicate a novel role for PS1 in regulating TREM2 intracellular trafficking and pathophysiological function.
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趙英軍 明知大學校 經濟硏究所 2002 경영연구 Vol.21 No.2
Since China became the members of WTO, all sectors will have chances and face challenges. What I am going to discuss in this paper focus on banking industry. We will expected that the banking in China will face problems as follows: to lose market share,good customer turn to foreign banks, profits shrink, brain drain, how to enter foreign market, to reform governance and meet the capital standard by BIS. I also present some advices about how to deal with those problems. 入世的成功, 標志着我國整體經濟開始對世界市場的全面開放. 這將從兩個方面對中國經濟形成影響, 一方面中國可以亨受到世界貿易組織條例指導下的各種貿易便利, 增加中國的貿易出口, 령一方面中國內部的經濟部門將必須面對來自國外的競爭壓力. 本文討論的就是中國所有經濟部門中競爭力相對薄弱的一個部門--銀行業. 수然,依据入世協議,我國的金融市場的全面開放獲得了一段珍貴的保護期, 在5年後才有外資銀行全面的合法進入. 但是在東部經濟發達地區, 外資銀行的進入이經開始. 尤其是在上海和深수的隣近地區. 按中國政府承諾的條件, 上海外資銀行的客戶現階段就可由上海市內擴大到江蘇, 浙江兩省, 實際的進入이經開始. 如花旗, 匯豊等國際性大銀行在上海的分行頻頻到浙江, 江蘇開展外匯結算, 外匯項目貸款, 外匯融資業務. 也就是說, 銀行業其實이經兵臨城下.
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Zhou, Zhengkui,Jiang, Yu,Wang, Zheng,Gou, Zhiheng,Lyu, Jun,Li, Weiyu,Yu, Yanjun,Shu, Liping,Zhao, Yingjun,Ma, Yanming,Fang, Chao,Shen, Yanting,Liu, Tengfei,Li, Congcong,Li, Qing,Wu, Mian,Wang, Min,Wu, Nature Publishing Group, a division of Macmillan P 2015 Nature biotechnology Vol.33 No.4
Understanding soybean (Glycine max) domestication and improvement at a genetic level is important to inform future efforts to further improve a crop that provides the world's main source of oilseed. We detect 230 selective sweeps and 162 selected copy number variants by analysis of 302 resequenced wild, landrace and improved soybean accessions at >11× depth. A genome-wide association study using these new sequences reveals associations between 10 selected regions and 9 domestication or improvement traits, and identifies 13 previously uncharacterized loci for agronomic traits including oil content, plant height and pubescence form. Combined with previous quantitative trait loci (QTL) information, we find that, of the 230 selected regions, 96 correlate with reported oil QTLs and 21 contain fatty acid biosynthesis genes. Moreover, we observe that some traits and loci are associated with geographical regions, which shows that soybean populations are structured geographically. This study provides resources for genomics-enabled improvements in soybean breeding.
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Functional significance of cholesterol metabolism in cancer: from threat to treatment
Xiao Mingming,Xu Jin,Wang Wei,Zhang Bo,Liu Jiang,Li Jialin,Xu Hang,Zhao Yingjun,Yu Xianjun,Shi Si 생화학분자생물학회 2023 Experimental and molecular medicine Vol.55 No.-
Cholesterol is an essential structural component of membranes that contributes to membrane integrity and fluidity. Cholesterol homeostasis plays a critical role in the maintenance of cellular activities. Recently, increasing evidence has indicated that cholesterol is a major determinant by modulating cell signaling events governing the hallmarks of cancer. Numerous studies have shown the functional significance of cholesterol metabolism in tumorigenesis, cancer progression and metastasis through its regulatory effects on the immune response, ferroptosis, autophagy, cell stemness, and the DNA damage response. Here, we summarize recent literature describing cholesterol metabolism in cancer cells, including the cholesterol metabolism pathways and the mutual regulatory mechanisms involved in cancer progression and cholesterol metabolism. We also discuss various drugs targeting cholesterol metabolism to suggest new strategies for cancer treatment.
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