A Potential Role of ppGalNAc-T13 in Neural Differentiation

Yingjiao Xu,Wenjie Pang,Aidong Shan,Wei Li,Yan Zha 한국당과학회 2012 한국당과학회 학술대회 Vol.2012 No.1

Glycosylation in the nervous system is thought to play a particularly important and dynamic role in both vertebrates and invertebrates. Mucin-type O-glycosylation is initiated by a large family of UDP- GalNAc:polypeptideα-N-acetylgalactosaminyltransferases (ppGalNAc-Ts, EC 2.4.1.41) which contains 20 members. ppGalNAc-T13 is one of the essential isoform, and has been found highly and restrictively expressed in the brain and neurons [1]. In this study, we found that the mRNA and protein expression of ppGalNAc-T13 was dramatically increasing during the all-trans retinoic acid (ATRA) induced neural differentiation of embryonic carcinoma P19 cells, mouse brain development and primary neuronal cultures. ppGalNAc-T13 was localized in axons of the neurons derived from P19 cells and the O-glycosylation level was simultaneously increased during the ATRA induced neural differentiation. Furthermore, up-regulation of ppGalNAc-T13 induced the formation of lamellipodia and a higher O-glycosylation level. These results imply that the high expression of ppGalNAc-T13 in neurons may play a regulatory role in the neural differentiation. Study to explore the roles of ppGalNAc-T13 in regulating neural differentiation is under way.

IMPULSE BUYING BEHAVIOR: AN ASSESSMENT OF SELF-INDULGENCE, FASHION CONSCIOUSNESS, AND REGRET AMONG YOUNG CONSUMERS

Yingjiao Xu,Delisia Matthews 글로벌지식마케팅경영학회 2016 Global Marketing Conference Vol.2016 No.7

There is a general consensus in the literature that impulse buying is normatively wrong, but accounts for a substantial volume of the goods sold every year across the broad range of product categories, including fashion products. Research revealed that young consumers particularly contributed greatly to the increase of impulse buying. While lack of self-control has been found strongly associated with the unplanned nature of impulse buying, with an environment of abundance and consumerism, self-indulgence, rather than lack of self-control, may become a more important driver for impulse buying for modern consumers (Sharma, Sivakumaran, & Marshall, 2011). Therefore, the purpose of this study is to investigate how self-indulgence influences young consumers’ impulse buying and the post purchase consumer regret. This study also aims to test the role of fashion consciousness in the relationship between young consumers’ self-indulgence and impulse buying for fashion products. Self-indulgence is considered a hedonistic tendency, which includes enjoying spending money on oneself, buying things for one’s own pleasure, and trying to enjoy life (Sharma, Sivakumaran, & Marshall, 2011). It was recognized as one of the two opposing cognitive forces leading to impulse behavior (Miao, 2011). While the impulse to purchase is comprised of anticipated pleasures and immediate gratification (Rook, 1987), ironically, consumer regret is one of the major emotional consequences associated with impulse buying. There are two types of consumer regret: cognitive dissonance, resulted from an immediate post-purchase comparison of what was purchased versus the other available alternatives, and consumer guilt, related specifically to the consumption decision situations. Literature suggested that individuals show interest in fashion products with the belief that fashion products will contribute to their appearance, image, and/or bring enjoyment to their life (Workman & Kidd, 2000). In that same token, an individual with high self-indulgence tendency is more likely to show interest in fashion in hopes of identifying fashion items for indulgence purpose. Moreover, this indulgence motivated fashion consciousness will more likely lead to high impulse buying for fashion products. Based on the literature, hypotheses were developed for this study as represented in the following figure. Data was collected using a survey of college students majored in textile/fashion management at a large southeast university in the USA. A total of 190 surveys were distributed and returned. The majority of the subjects were females (73.7%), white (74.7%), and held part-time work (56.7%). Existing scales were adopted to measure self-indulgence (Sharma, Sivakumaran, & Marshall, 2011) and fashion consciousness (Bruner & Hensel, 1998). Impulse buying behavior and post-purchase regret were measured by asking subjects to retroactively recall their shopping trips for fashion products during the past three months. A group of items developed by the researchers were used to measure both the impulse buying behavior and consumer regret. A Confirmatory Factor Analysis (CFA) was first employed to assess the psychometric properties of the constructs. Overall, the fit indices of the measurement model were acceptable (NFI=0.86, IFI=0.935, RMSEA=0.066, CMIN/DF=1.7). A Structural Equation Modeling (SEM) was conducted to test the relationship proposed in the hypotheses. To test the mediating effect of fashion consciousness on the relationship between self-indulgence and impulse buying behaviors, a bootstrapping bias-corrected confidence interval procedure was conducted. Overall, the fit indices of the SEM model were acceptable (CMN/df=1.338, NFI=0.90, IFI=0.97, RMSEA=0.044). The SEM results suggested that self-indulgence had a significant influence on impulse buying for fashion products directly and indirectly via fashion consciousness. The impulse purchase behavior had a positive influence on the consumers’ feeling of guilt for the impulse purchase behavior, while no significant influence was found on cognitive dissonance. This research makes several contributions to the literature of impulse buying. First, the study suggests that consumers’ self-indulgence exerts significant direct and indirect influences on consumers’ impulse buying for fashion products. This result may provide an explanation to the phenomenon of increasing impulse buying behavior in the marketplace, even though it is widely considered as a “misbehavior”. Secondly, this study suggests a significant mediating role of fashion consciousness in the relationship between self-indulgence on consumers’ impulse buying for fashion products. The abundance of fashion products in the market and the appreciation of the social and affective function of fashion products contribute to the chain effect from self-indulgence to fashion consciousness and finally to impulse purchase for fashion products. Third, this study confirms the negative guilt feeling resulted from the impulse buying behavior.

COPING WITH THE COVID-19 PANDEMIC IN THE CONTEXT OF FASHION SHOPPING: A STIMULUS-ORGANISM-RESPONSE (SOR) APPROACH

Hanna Lee,Yingjiao Xu,Wenna Han 글로벌지식마케팅경영학회 2023 Global Marketing Conference Vol.2023 No.07

The Covid-19 pandemic has caused unprecedented crises to societies and economies around the world and has brought drastic changes in the way consumers behave. Fashion business is one of the industries that has been significantly affected by Covid-19 as many consumers reduced their discretionary spending during the pandemic. While the world is entering the post-pandemic era and recovering from the pandemic, it is important to uncover and reflect on the reasons behind varying patterns of consumers’ coping behaviors associated with fashion shopping. However, current research on consumer fashion behavior during the pandemic primarily focuses on a particular type of shopping behavior, without addressing varying patterns of fashion consumption behaviors. In addition, most of these studies attributed such changes in behaviors to motivations toward protection against health-adverse threats based on the Protection Motivation Theory, which mostly focuses on protective behaviors and has limited power in understanding varying internal reasons toward various coping behaviors. Considering the varying adaptive and maladaptive patterns of fashion consumption behaviors observed in the market, it is important to address the psychological mechanism behind varying adaptive and maladaptive patterns of fashion consumption behaviors. Thus, drawing from the Stimulus-Organism-Response (SOR) framework, this study aims to investigate how cognitive appraisal of threats affects the affective/emotional state of consumers and consequently their intention to engage in various coping behaviors in the context of fashion shopping. Specifically, this study aims to investigate how individuals’ cognitive appraisals on risks and uncertainty induce varying emotional feelings (i.e., fear, anxiety, and hope), which further leads to their decisions to engage in problem vs. emotion-focused coping through fashion shopping during the pandemic.