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- 저자 : Yibo Yin (검색결과 2 건)
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Hongsheng Liang,Xiangtong Zhang,Yibo Yin,Tie Lin,Dong Guan,Bowen Ma,Changyu Li,Yuehua Wang 한국분자세포생물학회 2013 Molecules and cells Vol.36 No.1
The reorganization of brain structures after intracerebral hemorrhage (ICH) insult is crucial to functional outcome. Although the pattern of neuronal rewiring is well-docu-mented after ischemic stroke, the study of brain plasticity after ICH has been focusing on the enhancement of dendritic complexity. Here we hypothesized that functional restoration after ICH involves brain reorganization which may be favorably modulated by stem cell transplantation. In this study, bone marrow stromal cells (BMSCs) were transplanted into the perilesional sites of collagenase-induced ICH in adult rats one day after ICH injury. Forelimb functional recovery was monitored with modified limb placing and vibrissae-elicited forelimb placement tests. Anterograde and retrograde tracing were used to assess the reorganization of bilateral forelimb areas of the sen-sorimotor cortex. We found that in rats transplanted with BMSCs after ICH injury, axonal sprouting occurred in the contralateral caudal forelimb area of the cortex, and was significantly higher than in ICH rat models that received only the vehicle (P < 0.01). The number of positive neurons in the ipsilateral rostral forelimb area of the cortex of the BMSC group was 1.5- to 4.5-fold greater than in the vehicle group (P < 0.05). No difference was found between the BMSC and vehicle groups in hemispheric atrophy or labeled neurons in the ipsilateral caudal forelimb area (P = 0.193). Scores for improved functional behavior in the BMSC group were in accord with the results from histology. Neuronal plasticity of the denervated corticospinal tract at bilateral forelimb areas of the cortex in the collagenase-induced ICH rat models was significantly enhanced by BMSC transplantation. BMSC transplantation may facilitate functional recovery after ICH injury.
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Echinacoside Prevents Sepsis-Induced Myocardial Damage via Targeting SOD2
Jingxiang Wu,Xingji You,Xin Li,Zuojing Zhang,Xiaoxuan Zhang,Yibo Yin,Xinru Yuan 한국식품영양과학회 2024 Journal of medicinal food Vol.27 No.2
Echinacoside (ECH) is a prominent naturally occurring bioactive compound with effects of alleviatingmyocardial damage. We aimed to explore the beneficial effects of ECH against sepsis-induced myocardial damage andelucidate the potential mechanism. Echocardiography and Masson staining demonstrated that ECH alleviates cardiac functionand fibrosis in the cecal ligation and puncture (CLP) model. Transcriptome profiling and network pharmacology analysisshowed that there are 51 overlapping targets between sepsis-induced myocardial damage and ECH. Subsequently, chemicalcarcinogenesis-reactive oxygen species (ROS) were enriched in multiple targets. Wherein, SOD2 may be the potential targetof ECH on sepsis-induced myocardial damage. Polymerase chain reaction results showed that ECH administration couldmarkedly increase the expression of SOD2 and reduce the release of ROS. Combined with injecting the inhibitor of SOD2, thebeneficial effect of ECH on mortality, cardiac function, and fibrosis was eliminated, and release of ROS was increased afterinhibiting SOD2. ECH significantly alleviated myocardial damage in septic mice, and the therapeutic mechanism of ECH isachieved by upregulating SOD2 which decreased the release of ROS.
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