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Pan-Pan Shu,Lu-Xi Li,Qin-Min He,Jun Pan,Xiao-Lei Li,Min Zhu,Ye Yang,Yuan Qu 고려인삼학회 2021 Journal of Ginseng Research Vol.45 No.2
Background: Panax stipuleanatus represents a folk medicine for treatment of inflammation. However, lack of experimental data does not confirm its function. This article aims to investigate the analgesic and anti-inflammatory activities of triterpenoid saponins isolated from P. stipuleanatus. Methods: The chemical characterization of P. stipuleanatus allowed the identification and quantitation of two major compounds. Analgesic effects of triterpenoid saponins were evaluated in two models of thermal- and chemical-stimulated acute pain. Anti-inflammatory effects of triterpenoid saponins were also evaluated using four models of acetic acid-induced vascular permeability, xylene-induced ear edema, carrageenan-induced paw edema, and cotton pellet-induced granuloma in mice. Results: Two triterpenoid saponins of stipuleanosides R₁ (SP-R₁) and R₂ (SP-R₂) were isolated and identified from P. stipuleanatus. The results showed that SP-R₁ and SP-R₂ significantly increased the latency time to thermal pain in the hot plate test and reduced the writhing response in the acetic acid-induced writhing test. SP-R₁ and SP-R₂ caused a significant decrease in vascular permeability, ear edema, paw edema, and granuloma formation in inflammatory models. Further studies showed that the levels of inflammatory mediators, nitric oxide, malondialdehyde, tumor necrosis factor-α, and interleukin 6 in paw tissues were downregulated by SP-R₁ and SP-R₂. In addition, the rational harvest of three- to five-year-old P. stipuleanatus was preferable to obtain a higher level of triterpenoid saponins. SP-R₂ showed the highest content in P. stipuleanatus, which had potential as a chemical marker for quality control of P. stipuleanatus. Conclusion: This study provides important basic information about utilization of P. stipuleanatus resources for production of active triterpenoid saponins.
Association Between the FAS/FASL Polymorphisms and Gastric Cancer Risk: A Meta-Analysis
Tian, Jing,Pan, Feng,Li, Jing,Ma, Yan,Cen, Han,Pan, Hai-Feng,Pan, Yue-Yin,Ye, Dong-Qing Asian Pacific Journal of Cancer Prevention 2012 Asian Pacific journal of cancer prevention Vol.13 No.3
Objective: FAS/FASL gene promoter polymorphisms have been repeatedly associated with gastric cancer risk, but findings are inconclusive across studies. To address a more precise estimation of the relationship, a meta-analysis was performed. Methods: Data were collected from the Pubmed, Medline and EMBASE databases, with the last report up to 1 December, 2011. Crude ORs with 95% CIs were used to assess the strength of the association by (1) the additive, (2) the codominant, (3) the dominant, and (4) the recessive models. Results: A total of seven studies, including six studies on FAS -1377G>A polymorphism, five studies on FAS -670A>G polymorphism, and six studies on FASL -844T>C polymorphism, were identified in the current meta-analysis. Overall, an association of FAS -1377G>A (AA versus GG: OR = 1.313, 95% CI = 1.045-1.650, Ph = 0.347, $I^2$ = 10.8) and FASL -844T>C (CC versus TT: OR = 1.352, 95% CI = 1.043-1.752, Ph = 0.461, $I^2$ = 0.0) polymorphisms with gastric cancer was found in the codominant model. However, we did not detect any association between gastric cancer and the FAS -670A>G polymorphism. In the subgroup analysis by ethnicity, similar elevated risks were also observed in Asian population for FAS -1377G>A (AA versus GG: OR = 1.309, 95% CI = 1.041-1.646, Ph = 0.240, $I^2$ = 27.3) and FASL -844T>C (CC versus TT: OR = 1.420, 95% CI = 1.081-1.865, Ph = 0.524, $I^2$ = 0.0) polymorphisms. Conclusions: This meta-analysis indicated that FAS -1377G>A and FASL -844T>C polymorphisms might be associated with gastric cancer risk.
Imidazole derivatives for efficient organic light-emitting diodes
Ye Shaofeng,Zhuang Shaoqing,Pan Biao,Guo Runda,Wang Lei 한국정보디스플레이학회 2020 Journal of information display Vol.21 No.3
Since the first development of organic light-emitting diodes (OLEDs) in 1987, imidazole derivatives, mainly including phenanthroimidazole (PI) and benzimidazole (BI), have increasingly attracted attention. Their strong electron-withdrawing properties make them suitable for emitters, hosts, and electron-transporting materials (ETMs). In this review, an overview of the recent developments regarding OLEDs based on imidazole derivatives, especially the relationship between the molecule structure and the device performance as fluorescent and host materials, is given.
Ye Zhang,Yan Zhao,Hongwei Pan,Xianzhong Lang,Huili Yang,Huiliang Zhang,Huixuan Zhang,Lisong Dong 한국고분자학회 2016 폴리머 Vol.40 No.3
Polylactide (PLA) was plasticized with poly(diethylene glycol adipate) (PDEGA). The plasticized PLA was further blended with core-shell structured particles of glycidyl methacrylate-functionalized methyl methacrylate-butyl acrylate copolymer (GACR) using a twin-screw extruder, and the extruded samples were blown using the blown thin film technique. Both PDEGA and GACR significantly influenced the physical properties of the films. Compared to neat PLA, the elongation at break and tear strength of the films were significantly improved. The shear yielding induced by cavitation of GACR particles was the major tearing mechanism. GACR could act as a tear resistance modifier for PLA blown films. The spherulite size of the PLA/PDEGA/GACR films decreased with the addition of GACR. The biodegradability of the PLA/PDEGA/GACR films decreased slightly. These findings contributed new knowledge to the additive area and gave important implications for designing and manufacturing polymer packaging materials.
Ye, Ni,Wang, Bin,Quan, Zi-Fang,Pan, Hai-Bo,Zhang, Man-Li,Yan, Qi-Gui Asian Pacific Journal of Cancer Prevention 2014 Asian Pacific journal of cancer prevention Vol.15 No.3
MicroRNA expression is a research focus in studies of tumors. This article concentrates attention on potential links between tumors caused by mouse mammary tumor virus (MMTV) and human breast cancer, in order to provide theoretical basis for using mouse model to search for miRNA effects mediated by Wnt/beta-catenin signaling in human breast cancer. By analyzing interactions between miRNAs and the Wnt/beta-catenin signaling pathway in breast cancer, we hope to casts light on more biological functions of miRNAs in the process of tumor formation and growth and to explore their potential value in cancer diagnosis, prognosis and treatment. Our endeavor aimed at providing theoretical basis for finding safer, more effective methods for treatment of human breast cancer at the miRNA molecular level.
( Pan Su ),( Zhou Weiwei ),( Gu Qingqing ),( Ye Qiang ) 한국인터넷정보학회 2015 KSII Transactions on Internet and Information Syst Vol.9 No.1
Future wireless network aims to integrate different radio access networks (RANs) to provide a seamless access and service continuity. In this paper, a new resource denotation method is proposed in the WLAN and LTE heterogeneous networks based on a concept of spectral bandwidth mapping. This method simplifies the denotation of system resources and makes it possible to calculate system residual capacity, upon which an economic model-based network selection algorithm is designed in both under-loaded and over-loaded scenarios in the heterogeneous networks. The simulation results show that this algorithm achieves better performance than the utility function-based access selection (UFAS) method proposed in [12] in increasing system capacity and system revenue, achieving load balancing and reducing the new call blocking probability in the heterogeneous networks.
Ye Zhang,Shiling Jia,Pan Hongwei,Lijuan Wang,Junjia Bian,Yang Guan,Bohao Li,Huiliang Zhang,Huili Yang,Lisong Dong 한국화학공학회 2021 Korean Journal of Chemical Engineering Vol.38 No.8
A series of poly(lactic acid) (PLA), poly(butylene adipate-co-terephthalate) (PBAT) and glycidyl methacrylate- grafted poly(ethylene octene) (GPOE) blends and films with different GPOE content were prepared by melt blending and blowing film technique. The effect of GPOE on the rheological behavior, melt strength, crystallization behavior, crystallization morphology, miscibility, mechanical property, phase morphology, thermal stability and water vapor permeability were studied. The addition of GPOE improved melt rheological properties. Results of DSC showed that addition of GPOE encouraged the mobility of PLA molecular chains and enhanced crystalline ability. POM observations revealed that the addition of GPOE made the density of spherulite nucleation increase and the size of crystalline particles decrease. From DMA and SEM analysis, it was demonstrated that PLA/PBAT blend was an immiscible system and GPOE in the blend could improve compatibility between PLA and PBAT. Results of mechanical test showed that the PLA/PBAT/GPOE blends and films obtained had excellent mechanical properties. The elongation at break of 50/30/ 20 w/w/w PLA/PBAT/GPOE blend (477%) was higher by about 2.2 times than that of 70/30/0 w/w/w PLA/PBAT/ GPOE blend (220%). The tensile strength of all the PLA/PBAT/GPOE blends exceeded 31 MPa. The tensile strength reached 32.9MPa (MD) and 22.5MPa (TD), the elongation at break exceeded 210% and tear strength exceeded 140 kN/m for 50/30/20 w/w/w PLA/PBAT/GPOE film. With increasing GPOE content, thermal stability and water vapor barrier property also improved.
Establishment of a special pathogen free Chinese Wuzhishan Minipigs Colony
Pan, Jinchun,Min, Fangui,Wang, Xilong,Chen, Ruiai,Wang, Fengguo,Deng, Yuechang,Luo, Shuming,Ye, Jiancong Korean Society of Animal Science and Technology 2015 한국축산학회지 Vol.57 No.3
To meet the increasing demands of specific pathogen free (SPF) minipigs in biomedical researches, 8 pregnant Chinese Wuzhishan minipigs (WZSP) sows with clear background were chosen to obtain SPF WZSP by hysterectomy. At $111{\pm}days2$ of the pregnancy, piglets were aseptically taken out from the sows and artificially suckled for 40 to 45 days in the positive isolators. Then, the piglets defined as F0 were transferred to barrier environment and fed with standard feeds. The original SPF colony was formed for breeding by selected piglets from F0 group of 6-8 months old. Biological characteristics of SPF WZSP were collected and further compared to those of conventional (CV) WZSP, including growth performance, reproductive performance, hematology and blood biochemistry, and major pathogens detection. As a result, 61 F0 piglets were obtained from 8 candidate sows, and 55 out of them survived. After strictly selection, 35 F0 piglets were used to form the original SPF colony, which produced 14 litters of SPF piglets defined as F1. Piglet survival rates, growth performance, and reproductive performance of SPF WZSP were similar to CV WZSP. Some hematology and blood biochemistry parameters showed significant differences between SPF and CV WZSP. Eighteen kinds of pathogens were identified to be free in F0 and F1 SPF colony by repeated pathogen detections. In conclusion, we established a satisfied SPF WZSP colony maintaining original characteristics, free of controlled diseases, and being proved to be a suitable laboratory animal.