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Yasuyuki Yamada,Kensuke Nakajima,Koji Nakajima 한국물리학회 2006 THE JOURNAL OF THE KOREAN PHYSICAL SOCIETY Vol.48 No.5I
We investigate experimentally the dynamics of Josephson vortices interacting with electromagnetic waves in Bi2Sr2CaCu2O8+y intrinsic Josephson junction stacks by means of millimeter wave irradiation and numerical simulations based on coupled sine-Gordon equations. We have found that an introduction of pancake vortices by tilting the external magnetic field from CuO2 planes reveals Shapiro-step-like features on the flux-flow characteristics. Those steps are assumed to be a manifestation of an in-phase coherent motion of Josephson vortices caused by a periodic potential developed by pancake vortices. The results of the numerical simulation, taking into account the periodic potential, supports the validity of such an assumption.?
Osamu Mikami,Hiroyuki Yamaguchi,Hideo Murata,Yasuyuki Nakajima,Shigeru Miyazaki 대한수의학회 2010 Journal of Veterinary Science Vol.11 No.2
Six 1-month-old piglets were intravenously injected with deoxynivalenol (DON) at the concentration of 1 mg/kg body weight, with three pigs each necropsied at 6 and 24 h post-injection (PI) for investigation of hepatotoxicity and immunotoxicity with special attention to apoptotic changes and cytokine mRNA expression. Histopathological examination of the DON-injected pigs revealed systemic apoptosis of lymphocytes in lymphoid tissues and hepatocytes. Apoptosis of lymphocytes and hepatocytes was confirmed by the TdT-mediated dUTP-biotin nick end-labeling (TUNEL) method and immunohistochemical staining against singlestranded DNA and cleaved caspase-3. The number of TUNELpositive cells in the thymus and Peyer’s patches of the ileum was increased at 24 h PI compared to 6 h PI, but the peak was at 6 h PI in the liver. The mRNA expression of interleukin (IL)-1β, IL-6, IL-18, and tumor necrosis factor (TNF)-α in the spleen, thymus and mesenteric lymph nodes were determined by semi-quantitative RT-PCR, and elevated expression of IL-1β mRNA at 6 h PI and a decrease of IL-18 mRNA at 24 h PI were observed in the spleen. IL-1β and IL-6 mRNA expressions increased significantly at 6 h PI in the thymus, but TNF-α decreased at 6 h PI in the mesenteric lymph nodes. These results show the apoptosis of hepatocytes suggesting the hepatotoxic potential of DON, in addition to an immunotoxic effect on the modulation of proinflammatory cytokine genes in lymphoid organs with extensive apoptosis of lymphocytes induced by acute exposure to DON in pigs.