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RISS 인기검색어
- 검색키워드
- 저자 : Yasuo Yoshioka (검색결과 3 건)
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TOSHIHIRO ONA,AKI YOSHIOKA,YASUO KOJIMA,TERUYUKI SEINO,MIHO MIZUMOTO,HIDEO NOZAKI,YASUYUKI ISHIDA,HAJIME OHTANI 한국펄프·종이공학회 2006 한국펄프종이학회 기타 간행물 Vol.- No.-
Pyrolysis-gas chromatography (Py-GC) in the presence of organic alkali of tetrabutylammonium hydroxide (TBAH) was applied to characterize the polyphenol fragments with a carbonyl group causing different magnitude of photoyellowing in chemithermomechanical pulp (CTMP) papers. Two different origin of CTMP papers prepared from different individuals of Eucalyptus globulus trees showing high and low yellowing after photo-irradiation was compared before photo-irradiation. As a result, 7 peaks assigned to a series of phenol compounds with a carbonyl group, derived mainly from lignin, gave significant amount of phenol compounds with a carbonyl group for the paper sample of latent high yellowing, i.e., butoxy- and syringaldehyde, butoxy- and syringylacetone, butoxy-acetoguaiacone, butoxy-acetosyringone, butoxy-acetoethylsyringone, 3-methoxy-4-butoxy butyl ester, and 3,5-dimethoxy-4-butoxy butyl ester, using Py-GC/mass spectrometry (MS). The Py-GC method combined with TBAH successfully characterized polyphenol fragments with a carbonyl group causing differ high photo-yellowing in CTMP papers using a microgram order of samples.
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Seok, Young Mi,Azam, Mohammed Ali,Okamoto, Yasuo,Sato, Atsushi,Yoshioka, Kazuaki,Maeda, Masataka,Kim, InKyeom,Takuwa, Yoh Ovid Technologies Wolters Kluwer -American Heart A 2010 Hypertension Vol.56 No.5
<P>Rho-mediated inhibition of myosin light chain (MLC) phosphatase (MLCP), together with Ca2+-dependent MLC kinase activation, constitutes the major signaling mechanisms for vascular smooth muscle contraction. We recently unveiled the involvement of Ca2+-induced, phosphoinositide 3-kinase (PI3K) class II alpha isoform (PI3K-C2 alpha)-dependent Rho activation and resultant Rho kinase-dependent MLCP suppression in membrane depolarization- and receptor agonist-induced contraction. It is unknown whether Ca2+ - and PI3K-C2 alpha-dependent regulation of MLCP is altered in vascular smooth muscle of hypertensive animals and is involved in hypertension. Therefore, we studied the role of the Ca2+-PI3K-C2 alpha-Rho-MLCP pathway in spontaneously hypertensive rats (SHRs). PI3K-C2 alpha was readily detected in various vascular beds of Wistar-Kyoto rats and activated by high KCl. High KCl also stimulated vascular Rho activity and phosphorylation of the MLCP regulatory subunit MYPT1 at Thr(853) in a PI3K inhibitor wortmannin-sensitive manner. In mesenteric and other vessels of SHRs at the hypertensive but not the prehypertensive stage, the activity of PI3K-C2 alpha but not class I PI3K p110 alpha was elevated with concomitant rises of Rho activity and Thr(853)-phosphorylation of MYPT1, as compared with normotensive controls. Infusion of the Ca2+ channel antagonist nicardipine reduced blood pressure with suppression of vascular activity of PI3K-C2 alpha-Rho and phosphorylation of MYPT1 in hypertensive SHRs. Infusion of wortmannin lowered blood pressure with inhibition of PI3K-C2 alpha-Rho activities and MYPT1 phosphorylation in hypertensive SHRs. These observations suggest that an increased activity of the Ca2+-PI3K-C2 alpha-Rho signaling pathway with resultant augmented MLCP suppression contributes to hypertension in SHRs. The Ca2+- and PI3K-C2 alpha-dependent Rho stimulation in vascular smooth muscle may be a novel, promising target for treating hypertension. (Hypertension. 2010;56:934-941.)</P>
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Ken Yoshida,Hideya Yamazaki,Satoaki Nakamura,Koji Masui,Tadayuki Kotsuma,Hironori Akiyama,Eiichi Tanaka,Nobuhiko Yoshikawa,Yasuo Uesugi,Taiju Shimbo,Yoshifumi Narumi,Yasuo Yoshioka 대한부인종양학회 2015 Journal of Gynecologic Oncology Vol.26 No.3
Objective: To assess actual rates of late vaginal stenosis and identify predisposing factors for complications among patients with previously untreated cervical cancer following high-dose-rate brachytherapy. Methods: We performed longitudinal analyses of 57 patients using the modified Dische score at 6, 12, 18, 24, 36, and 60 months after treatment, which consisted of 15 interstitial brachytherapys and 42 conventional intracavitary brachytherapys, with a median follow-up time of 36 months (range, 6 to 144 months). Results: More than half of the patients developed grade 1 (mild) vaginal stenosis within the first year of follow-up, and grade 2 (97.5%, moderate) to grade 3 (severe) stenosis gradually increased with time. Actual stenosis rates for grade 1, 2, and 3 were 97.5% (95% confidence interval [CI], 92.7 to 97.5), 60.7% (95% CI, 42.2 to 79.3), and 7.4% (95% CI, 0 to 18.4) at 3 years after treatment. Pallor reaction grade 2–3 at 6 months was only a statistically significant predisposing factor for grade 2–3 late vaginal stenosis 3 years or later with a hazard ratio of 3.48 (95% CI, 1.32 to 9.19; p=0.018) by a multivariate Cox proportional hazard model. Patients with grade 0–1 pallor reaction at 6 months showed a grade ≥2 vaginal stenosis rate of 53%, whereas the grade 2–3 pallor reaction group achieved a grade ≥2 vaginal stenosis rate at 3 years at 100% (p=0.001). Conclusion: High-dose-rate brachytherapy was associated with high incidence of late vaginal stenosis. Pallor reaction grade 2–3 at 6 months was predictive of late grade 2–3 vaginal stenosis at 3 years after treatment. These findings should prove helpful for patient counseling and preventive intervention.
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