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Yasumasa Kuwahara,Naoki Mori,Kiminori Shimizu,Chihiro Tanaka,Mitusya Tsuda Korean Society of Applied Entomology 1998 Journal of Asia-Pacific Entomology Vol.1 No.1
Female sex pheromones, which elicit mounting behavior of conspecific males, were identified in 4 species of the genus Caloglyphus(Acarina: Acaridae). Although the sex pheromones are distributed over both males and femles, they could be classified into two groups; one is an adult-specific pheromone, and the other is one that is detectable even in nymphal stages. In addition, in the adult-specific species, the pheromonal content ratios of female to male were found to be larger than those observed in the nonspecific species. The two types of pheromonal distribution were compared with phylogenetic relationships based on a portion of the mitochondrial cytochrome oxidase subunit I(COI) gene in the four species. The polymerase chain reaction was used to amplify the COI from the four mites, with primers used in spider mites(Tetranychidae). Fragments of the COI(453bp) were obtained for the three species. The phylogenetic tree, based on the COI sequences, was inferred using a maximum parsimony method. Analysis of the pheromonal distribution within this phylogenetic framework agreed with the hypothesis that the mite sex pheromone evolved from a common compound, which originally fundtioned as a male sexual excitant, into a biologically active, sex linked specific one.
Allergenicity of simple chemicals in house dust mites detected by patch tests
Hideo Nakayama,Akiko Kumei,Naoki Mori,Yasumasa Kuwahara 한국응용곤충학회 2008 한국응용곤충학회 학술대회논문집 Vol.2008 No.10
Eczema due to contact allergy is usually produced by simple chemicals with the molecules less than 500 KD. A total of 100 cultivated house dust mites (HDM) were extracted with their lipid components in hexane, and they were analyzed by mass measuring gas chromatography. The same components were mixed in petrolatum at 5% or less, and patch tested using Finn Chambers, and the results were read by ICDRG standards. α-Acaridial, contained in Tyrophagus putrescentiae, turned out to have been a primary sensitizer, and could make prurigo reactions. Geranial, a main lipid component in dermatophagoides, showed positive rates at 58.8% at 5% concentration in atopic dermatitis and was expected to cross react to geraniol in cosmetics and soaps. It means that when one is sensitized by HDM, eczema can be provoked and maintained by the usage of ordinary soaps, shampoos and cosmetics, containing geraniol.
Induction of allergic contact dermatitis by astigmatid mite-derived monoterpene, α-acaridial
Toshio Sasai,Yunosuke Hirano,Sayaka Maeda,Isamu Matsunaga,Atsushi Otsuka,Daisuke Morita,Ritsuo Nishida,Hideo Nakayama,Yasumasa Kuwahara,Masahiko Sugita,Naoki Mori 한국응용곤충학회 2008 한국응용곤충학회 학술대회논문집 Vol.2008 No.10
α-Acaridial [2(E)-(4-methyl-3-pentenyl)butenedial] is a novel monoterpene secreted from the house dust mites. Because of its molecular nature of a highly reactive, small lipidic compound, we addressed whether α-acaridial might function as a haptenic allergen that induced allergic contact dermatitis. Mice sensitized with α-acaridial were challenged by the same antigen on the ear skin. After 2 days, significant ear swelling with a prominent infiltration of CD4+ T lymphocytes was observed. In vitro, α-acaridial exhibited an outstanding ability to quickly interact with and chemically modify a reference protein. Virtually all cysteine residues and a sizable fraction of lysine residues were found to be selectively modified, suggesting that α-acaridial could potentially interact with any proteins. Previously, numerous mite-derived proteinaceous allergens have been associated with contact dermatitis. Our study now emphasizes that small lipidic compounds released from mites comprise a new class of mite allergens, and therefore, is of significant medical implications.