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Yang Weina,Kang Qian,Li Chunlei,Bo Shuchun,Wang Yue 대한독성 유전단백체 학회 2023 Molecular & cellular toxicology Vol.19 No.3
Background During preeclampsia (PE), reactive oxygen species (ROS) production and infl ammation are increased. Matrine exerts diverse pharmacological eff ects, including anti-infl ammatory and anti-apoptotic eff ects. Objective The present study aimed to study the therapeutic eff ects of matrine on PE. Human trophoblasts (HTR-8/SVneo cells) were treated with H 2 O 2 to simulate oxidative stress, followed by treatment with various concentrations of matrine. Next, fl ow cytometry was used to examine apoptosis. Cell invasion and migration were examined by Transwell and scratch wound assays, respectively. The concentrations of IL-6, IL-8, and TNF-α were quantifi ed by enzyme-linked immunosorbent assays. The expression levels of miR-19a-3p and ZEB2 were quantifi ed by qRT-PCR. The interaction between miR-19a-3p and ZEB2 was examined by a dual-luciferase reporter assay. Result Matrine attenuated H 2 O 2 -induced increases in ROS levels, apoptosis, and cytokine release in HTR/SVneo cells. Matrine also increased cell migration and invasion during oxidative stress by reducing miR-19a-3p expression. Moreover, miR-19a-3p can target ZEB2 directly. Conclusion During oxidative stress, matrine can reduce ROS levels, apoptosis, and infl ammation in human trophoblasts and promote migration and invasion via miR-19a-3p, off ering a potential new approach for the treatment of PE.
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Xiaojiang Gao-Zeller,Xiaodong Li,Fan Yang,Weina Zhu 대한토목학회 2019 KSCE JOURNAL OF CIVIL ENGINEERING Vol.23 No.5
Chinese construction companies, represented by huge Chinese construction corporations (HCCCs), have taken steps to develop their CSR (corporate social responsibility) strategy. To investigate the driving mechanisms of the CSR strategy of HCCCs, an analytical framework is proposed based on neo-institutional theory to explore how organizational legitimacy affects managerial perceptible institutional pressures and ultimately affects the development of CSR strategy. Specific scales were developed for HCCCs, and a questionnaire survey was conducted. Structural equation modelling was adopted to verify the paths proposed by the theoretical model. The results show that the expectations of the public and subcontractors/suppliers do not constitute sources of HCCCs’ organizational legitimacy. Different stakeholders have different influences on different institutional pressures. Environmental organizations have the most prominent effects. Government can reduce concerns about the CSR performance of HCCCs in society, and clients have a significant influence on the formation of institutional pressure, but employees' demands still need to be taken seriously by management. Additionally, due to the lack of regulations and norms in China, the promotion of CSR strategies relies mainly on the spontaneous demands of HCCCs. The applicability of neo-institutional theory to construction corporations is verified. The identified driving mechanisms help to effectively promote business strategy for HCCCs.
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