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( Huofeng Jiang ),( Yamin Gao ),( Sheng Zeng ),( Shuai Wang ),( Zhizhong Cao ),( Yaoju Tan ),( Huancai Yin ),( Jianxiong Liu ),( Tianyu Zhang ) 한국미생물생명공학회(구 한국산업미생물학회) 2019 Journal of microbiology and biotechnology Vol.29 No.9
The rising cases of multidrug-resistant Acinetobacter baumannii (Ab) and the lack of effective drugs call for quick attention. Here, based on a Tn7 transposon and Xer/dif system, we constructed a stable, selectable marker-free autoluminescent Ab capable of producing visible light without extra substrates. Utilization of this autoluminescent reporter strain has the potential to reduce the time, effort and costs required for the evaluation of activities of anti-Ab drug candidates in vitro.
Interleukin-6 signaling regulates hematopoietic stem cell emergence
Ruxiu Tie,Honghu Li,Shuyang Cai,Zuyu Liang,Wei Shan,Binsheng Wang,Yamin Tan,Weiyan Zheng,He Huang 생화학분자생물학회 2019 Experimental and molecular medicine Vol.51 No.-
Hematopoietic stem cells (HSCs) produce all lineages of mature blood cells for the lifetime of an organism. Invertebrates, HSCs derive from the transition of the hemogenic endothelium (HE) in the floor of the embryonic dorsalaorta. Most recently, a series of proinflammatory factors, such as tumor necrosis factor-α, interferon-γ, and Toll-likereceptor 4, have been confirmed to play a key role in HSC specification. However, the full complement of necessarysignaling inputs remains unknown to date. Here, we show that interleukin-6R (IL6R) via IL6 is required and sufficient forHSC generation. We found that Notch activates IL6R by regulating its expression in the HE and in HSCs. The secretionof IL6 mainly originates from HSC-independent myeloid cells, but not from HSCs and their adjacent vascularendothelial cells. In addition, blocking IL6 signaling does not affect vascular development or the production ofprimitive erythrocytes. Taken together, our results uncover a previously obscure relationship between IL6 signaling andHSC production and provide new insights into HSC regeneration using proinflammatory factors in vitro.