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First Record of Epinephelus heniochus(Perciformes: Serranidae) from Korea
Yagishita, Naoki,Jeon, Sang-Rin,Nakabo, Tetsuji 한국어류학회 2003 韓國魚類學會誌 Vol.15 No.2
2000년 5월 21일 제주도 남제주군 대정읍 가파리 (가파도)에서 Epinephelus heniochus Fowler, 1904의 표본 1개체가 채집되었다. 이 표본을 본 종의 한국에 있어서의 첫 기록이기에 기재를 행하고 신한국명 "봉줄바리"를 제창하였다. An example of Epinephelus heniochus Fowler, 1904, collected from Gap'a-ri, Gap'a Island, Daejong-up, Namjeju-gun, Jeju, Korea in May, 2000, in the first record of the species from Korea. A description of the specimen and a new Korean name "Bol-jul-bari" for the species are included.
Cytoplasmic destruction of p53 by the endoplasmic reticulum-resident ubiquitin ligase ‘Synoviolin’
Yamasaki, Satoshi,Yagishita, Naoko,Sasaki, Takeshi,Nakazawa, Minako,Kato, Yukihiro,Yamadera, Tadayuki,Bae, Eunkyung,Toriyama, Sayumi,Ikeda, Rie,Zhang, Lei,Fujitani, Kazuko,Yoo, Eunkyung,Tsuchimochi, K Wiley (John WileySons) 2007 The EMBO journal Vol.26 No.1
<P>Synoviolin, also called HRD1, is an E3 ubiquitin ligase and is implicated in endoplasmic reticulum -associated degradation. In mammals, Synoviolin plays crucial roles in various physiological and pathological processes, including embryogenesis and the pathogenesis of arthropathy. However, little is known about the molecular mechanisms of Synoviolin in these actions. To clarify these issues, we analyzed the profile of protein expression in synoviolin-null cells. Here, we report that Synoviolin targets tumor suppressor gene p53 for ubiquitination. Synoviolin sequestrated and metabolized p53 in the cytoplasm and negatively regulated its cellular level and biological functions, including transcription, cell cycle regulation and apoptosis. Furthermore, these p53 regulatory functions of Synoviolin were irrelevant to other E3 ubiquitin ligases for p53, such as MDM2, Pirh2 and Cop1, which form autoregulatory feedback loops. Our results provide novel insights into p53 signaling mediated by Synoviolin.</P>