Health-related Quality of Life among Breast Cancer Patients and its Influencing Factor in a Chinese Population

Shen, Fang-Rong,Liu, Ming,Zhang, Xia,Feng, Ya-Hong,Zhou, Long-Shu,Chen, You-Guo Asian Pacific Journal of Cancer Prevention 2012 Asian Pacific journal of cancer prevention Vol.13 No.8

Aim: The aim of this study was to investigate the quality of life (QOL) of breast cancer patients by using the Functional Assessment of Cancer Therapy-Breast (FACT-B) questionnaires. Methods: A total of 522 adult patients who were admitted to our hospital with breast cancer were collected during the period of Jun. 2007 to Dec. 2009. Results: Our FACT-B questionnaire study suggested that women below 50 years old, employed, higher education and annual income, lower TNM stage and receiving modified radical mastectomy manifested significantly better QOL using the assessment tool of the FACT-B subscale. Moreover, regression analysis indicated patients with young age, low stage cancer, high education and income were more likely to have high score of QOL, with ORs (95% CI) of 2.8 (1.52-4.56), 2.1 (1.15-3.95), 3.1 (1.45-5.12) and 3.54 (1.54-5.43), respectively. Conclusions: Our study showed younger age, lower stage of cancer, higher education and income could influence the QOL of breast cancer patients in our Chinese population. Further large sample studies are still needed for confirmation.

Systemic Analysis on Risk Factors for Breast Cancer Related Lymphedema

Zhu, Ya-Qun,Xie, Yu-Huan,Liu, Feng-Huan,Guo, Qi,Shen, Pei-Pei,Tian, Ye Asian Pacific Journal of Cancer Prevention 2014 Asian Pacific journal of cancer prevention Vol.15 No.16

Background: To evaluate risk factors for upper extremity lymphedema due to breast cancer surgery. Materials and Methods: Clinical studies published on PubMed, Ovid, EMbase, and Cochrane Library from January 1996 to December 2012 were selected. Results: Twenty-five studies were identified, including 12,104 patients. Six risk factors related to the incidence of lymphedema after breast cancer treatment were detected: axillary lymph node dissection (OR=3.73, 95%CI 1.16 to 11.96), postoperative complications (OR=2.64, 95%CI 1.10 to 6.30), hypertension (OR=1.83, 95%CI 1.38 to 2.42), high body mass index (OR=1.80, 95%CI 1.30 to 2.49), chemotherapy (OR=1.38, 95%CI 1.07 to 1.79) and radiotherapy (OR=1.35, 95%CI 1.10 to 1.66). We found significant protective factors for lymphedema: pathologic T classification (OR=0.57, 95%CI 0.36 to 0.91) and stage (OR=0.60, 95%CI 0.39 to 0.93), while some factors, like age, number of positive lymph nodes, number of lymph node dissection, demonstrated no obvious correlation. Conclusions: Axillary lymph node dissection, postoperative complications, hypertension, body mass index, chemotherapy, radiotherapy are risk factors for lymphedema after breast cancer treatment. Attention should be paid to patients with risk factors to prevent the occurrence of lymphedema.

Expression and Prognostic Roles of TRPV5 and TRPV6 in Non-Small Cell Lung Cancer after Curative Resection

Fan, Hong,Shen, Ya-Xing,Yuan, Yun-Feng Asian Pacific Journal of Cancer Prevention 2014 Asian Pacific journal of cancer prevention Vol.15 No.6

Purpose: We investigated the expression of epithelial $Ca^{2+}$ channel transient receptor potential vanilloid (TRPV) 5 and 6 in non-small-cell lung cancer (NSCLC) and assessed their prognostic role in patients after surgical resection. Materials and Methods: From January 2008 to January 2009, 145 patients who had undergone surgical resection of NSCLCs were enrolled in the study. Patient clinical characteristics were retrospectively reviewed. Fresh tumor samples as well as peritumor tissues were analyzed for TRPV5/6 expression using immune-histochemistry (IHC) and quantitative reverse transcriptase-polymerase chain reaction (RT-PCR). Patients were grouped based on their TRPV5 and TRPV6 levels in the tumor tissues, followed up after surgery, and statistically analyzed to examine the prognostic roles of TRPV5 and TRPV6 on patients' survival after surgical resection of NSCLCs. Results: Using IHC, among the 145 patients who had undergone surgical resection of NSCLCs, strong protein expression (grade${\geq}2$) of TRPV5 and TRPV6 was observed in a lower percentage of primary tumor tissues than in non-tumor tissues of same patients. Similar findigns were obtained with the RT-PCR test for mRNA levels. Decreased overall mRNA levels of TRPV5 and TRPV6 were associated with a worse overall survival rate (p=0.004 and p=0.003 respectively) and shorter recurrence-free survival (p<0.001 and p<0.001 respectively). The combining effect of TRPV5 and TRPV6 on survival was further investigated using multivariate analysis. The results showed that a combination of low expression of TRPV5 and TRPV6 could be an independent predictor of poor recurrence-free survival (p=0.002). Conclusions: Decreased expression of TRPV5/6 in tumor tissues was observed in NSCLC patients and was associated with shorter median survival time after surgical resection. Combined expression of TRPV5 and TRPV6 in tumor tissues demonstrated promising prognostic value in NSCLC patients.

Ring Oxpening Polymerization of D,L-Lactide on Magnetite Nanoparticles

Tian Jing,Feng Ya-Kai,Xu Yong-Shen The Polymer Society of Korea 2006 Macromolecular Research Vol.14 No.2

The ring-opening polymerization of D,L-lactide initiated by tin(II) 2-ethylhexanoate $(Sn(Oct)_2)$ on the surface-initiated magnetite $(Fe_{3}O_4)$ nanoparticles was performed at $130^{\circ}C$. The effects of the polymer molar mass and concentration on the amount of surface polymer were investigated. The number average molecular weights, $M_n$, obtained by both NMR and GPC methods fit well within the accuracy of the applied methods and ranged from 1,100 to $4,040g\;mol^{-1}$. A surface functionalization density of up to 625 initiation sites per particle was obtained. The composition of various core-shell particles was determined by TGA, with results indicating magnetite $(Fe_{3}O_4)$ contents, ${\mu}m$, between 17 and 59 wt%. Under the influence of a magnetic field, the heating generated by superparamagnetic core-shell particles suspended in toluene presented guidelines for an optimization of magnetic particle systems with respect to an application for hyperthermia.

Ring Oxpening Polymerization of D,L-Lactide on Magnetite Nanoparticles

Jing Tian,Ya Kai Feng,Yong Shen Xu 한국고분자학회 2006 Macromolecular Research Vol.14 No.2

Aspartate Transaminase to Platelet Ratio Index (APRI) and Albumin-Bilirubin Grade (ALBI) Predict Postoperative Morbidity Following Hepatectomy for Hepatocellular Carcinoma A Multicenter Cohort Study

( Tian Yang ),( Li-yang Sun ),( Lei Liang ),( Ya-hao Zhou ),( Wei-min Gu ),( Hong Wang ),( Ting-hao Chen ),( Yong-yi Zeng ),( Wan Yee Lau ),( Meng-chao Wu ),( Feng Shen ) 대한간학회 2020 춘·추계 학술대회 (KASL) Vol.2020 No.1

Aims: Postoperative morbidity following hepatectomy remains high, and understanding its risk factors is important to improve perioperative outcomes. We aimed to identify the role of two non-invasive markers - albumin-bilirubin (ALBI) and aspartate transaminase to platelet ratio index (APRI) - in predicting postoperative morbidity following hepatectomy for hepatocellular carcinoma (HCC). Methods: A multicenter data of patients undergoing hepatectomy for HCC at 8 centers were retrospectively analyzed. These patients were divided into normal and high groups according to preoperative ALBI and APRI scores. ALBI and APRI’s predictive accuracy of postoperative 30-day overall and major morbidity were evaluated by the area under the receiver operating characteristic curve (AUC) and compared with two conventional scores: Child-Pugh grade and model for end-stage liver disease (MELD). Results: In 2,301 patients, 866 (37.6%) and 400 (17.4%) were in the high ALBI and APRI groups, respectively. There were significant differences of postoperative overall morbidity between the normal and high ALBI groups (26.2% vs. 40.1%, P<0.001), as well as between the normal and high APRI groups (29.2% vs. 42.4%, P<0.001). The AUCs of the ALBI and APRI scores for predicting overall morbidity are greater than those of Child- Pugh grade and MELD score. Multivariable analyses revealed that ALBI and APRI were independent predictors of overall morbidity in both preoperative and postoperative prediction models. Similar results existed in predicting postoperative major morbidity. Conclusions: Preoperative ALBI and APRI could predict postoperative 30-day overall and major morbidity following hepatectomy for HCC before or after surgery.

Dynamic expression of early responsible genes to acute left-ventricular ischemia in a time-dependent pattern

XiaoWei Song,Yong Ji Yang,Ya Feng Shen,Mi Cao,QingNing Yuan,Ying Tang,Changhai Lei 한국통합생물학회 2014 Animal cells and systems Vol.18 No.3

Acute myocardial infarction remains one of the leading causes of death and disability worldwide. Themechanisms underlying myocardial infarction involve a complex of signaling molecules, such as tumornecrosis factor α (TNFα), interleukin-6 (IL6), C-Myc, atria natriuretic peptide (ANP), superoxide dismutase1 (SOD1), and so on. The aim of this study is to understand the time-dependent expressional pattern of theseearly responsible genes following acute myocardial ischemia established by left anterior descending (LAD)coronary artery ligation. After LAD ligation, a collection of genes was detected using real-time polymerasechain reaction (PCR). The expression of inflammation-related genes, such as TNFα and IL6, was immediatelyupregulated at 2 h, reached to the highest point at 12 h, and then decreased to nearly basis level at 24 h afterligation, suggesting inflammation appeared and disappeared rapidly after acute ischemia. C-Myc, an importanttranscription factor, was significantly upregulated at 2 h, and thereafter persisted at high level to 24 h. Thesecretary peptide, ANP, was consistently upregulated from 2 to 24 h, reached to 40-folds at 24 h. The calciumregulatedgene, FK506-binding protein 12.6, was not significantly altered after ischemia. SOD1 was not alteredat the first 4 h, and began to downregulate at 12 and 24 h. These results indicate that several genes weredynamically and transiently regulated after acute myocardial infarction (AMI) in a time-dependent pattern,suggesting that there is an immediate molecular response to acute myocardial ischemia, which might provideus a new insight to understand molecular mechanisms of AMI.

Mechanism of lithium storage in MoS2 and the feasibility of using Li2S/Mo nanocomposites as cathode materials for lithium-sulfur batteries.

Fang, Xiangpeng,Guo, Xianwei,Mao, Ya,Hua, Chunxiu,Shen, Lanyao,Hu, Yongsheng,Wang, Zhaoxiang,Wu, Feng,Chen, Liquan Wiley-VCH 2012 Chemistry, an Asian journal Vol.7 No.5

<P>The most-popular strategy to improve the cycling stability and rate performance of the sulfur electrode in lithium-sulfur (Li-S) batteries is to astrict the sulfur in a conducting medium by using complicated chemical/physical processing. Lithium sulfide (Li(2)S) has been proposed as an alternative electrode material to sulfur. However, for its application, it must meet challenges such as high instability in air together with all of the drawbacks of a sulfur-containing electrode. Herein, we report the feasibility of using Li(2)S, which was obtained by electrochemical conversion of commercial molybdenum disulfide (MoS(2)) into Li(2)S and metallic molybdenium (Mo) at low voltages, as a high-performance active material in Li-S batteries. Metallic Mo prevented the dissolution of lithium polysulfides into the electrolyte and enhanced the conductivity of the sulfide electrode. Therefore, the in situ electrochemically prepared Li(2)S/Mo composite exhibited both high cycling stability and high sulfur utilization.</P>

The Effects of ASMase Mediated Endothelial Cell Apoptosis in Multiple Hypofractionated Irradiations in CT26 Tumor Bearing Mice

Zhu, Hong,Deng, Kai,Zhao, Ya-Qin,Wang, Xin,Shen, Ya-Li,Liu, Tai-Guo,Cui, Dan-Dan,Xu, Feng Asian Pacific Journal of Cancer Prevention 2015 Asian Pacific journal of cancer prevention Vol.16 No.11

Background: To investigate the effects of ASMase mediated endothelial cell apoptosis in multiple hypofractionated irradiations in CT26 tumor bearing mice. Materials and Methods: Thirty-five CT26 tumor bearing mice were subjected to single ionizing radiation (IR) of 0, 3, 6, 9, 12, 15, 18 Gy. Eight hours after IR, the mice were sacrificed and tumor tissues were used for CD31 immunohistochemistry staining, TUNEL and CD31 double staining, ASMase activity assay. Then 6 and 12 Gy were chosen for multiple hypofractionated IR experiments according to the above results. Each time after IR, 5 mice were sacrificed and assayed as above. Results: The ASMase activities were increased significantly after a single IR of 12 Gy or higher which was accompanied with remarkable increased endothelial cell apoptosis and decreased MVD. For 6 Gy which was not high enough to trigger ASMase activation, after 2 or more times of IR, the ASMase activities were significantly increased accompanied with remarkable increased endothelial cell apoptosis and decreased MVD. While for 12 Gy, after 2 or more times of IR, the ASMase activities and endothelial cell apoptosis rates were maintained without remarkable increase; however, the MVD was significantly decreased. What's more, the cancer cell apoptosis rates were significantly increased after multiple IR for both 6 Gy and 12 Gy. Conclusions: ASMase mediated endothelial cell apoptosis may play an important role in the process of multiple hypofractionated IR for CT26 colorectal carcinoma.

Step-size adaptive parametric level set method for structural topology optimization

Chen-Dong Yang,Jian-Hu Feng,Ya-Dong Shen 대한기계학회 2022 JOURNAL OF MECHANICAL SCIENCE AND TECHNOLOGY Vol.36 No.10

In the structural topology optimization (STO), the step-size of the parametric level set method (PLSM) using the explicit scheme must satisfy the Courant-Friedrichs-Lewy (CFL) condition to ensure numerical stability. However, much larger step-sizes are arbitrarily used to speed up the convergence. For this reason, a narrowband in the velocity field is defined, and the step-size adaptive parametric level set method (SAPLSM) is proposed, which multiplies different step-sizes for the velocity of different nodes. The SAPLSM satisfies the CFL condition not only on the narrowband, but also on the entire design domain. Furthermore, a narrowband annealing (NA) scheme based on “annealing” is proposed to dynamically adjust the maximum step-size during the iterations. Numerical experimental results of several benchmark problems in two-dimensional minimum compliance show that: (1) The SAPLSM is more stable than PLSM under large step-sizes and complex problems. (2) The NA scheme not only accelerates the convergence of SAPLSM but also alleviates mesh dependence.