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- 저자 : Xuesheng Zhang (검색결과 4 건)
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Jianye Zhang,Kailin Li,Feng Kong,Chao Sun,Denglu Zhang,Xin Yu,Xuesheng Wang,Xian Li,Tongyan Liu,Guangfeng Shao,Yong Guan,Shengtian Zhao 한국조직공학과 재생의학회 2019 조직공학과 재생의학 Vol.16 No.6
BACKGROUND: Chronic kidney disease is a severe threat to human health with no ideal treatment strategy. Mature mammalian kidneys have a fixed number of nephrons, and regeneration is difficult once they are damaged. For this reason, developing an efficient approach to achieve kidney regeneration is necessary. The technology of the combination of decellularized kidney scaffolds with stem cells has emerged as a new strategy; however, in previous studies, the differentiation of stem cells in decellularized scaffolds was insufficient for functional kidney regeneration, and many problems remain. METHODS: We used 0.5% sodium dodecyl sulfate (SDS) to produce rat kidney decellularized scaffolds, and induce adipose-derived stem cells (ADSCs) into intermediate mesoderm by adding Wnt agonist CHIR99021 and FGF9 in vitro. The characteristics of decellularized scaffolds and intermediate mesoderm induced from adipose–derived stem cells were identified. The scaffolds were recellularized with ADSCs and intermediate mesoderm cells through the renal artery and ureter. After cocultured for 10 days, cells adhesion and differentiation was evaluated. RESULTS: Intermediate mesoderm cells were successfully induced from ADSCs and identified by immunofluorescence and Western blotting assays (OSR1 ? , PAX2 ?). Immunofluorescence showed that intermediate mesoderm cells differentiated into tubular-like (E-CAD ? , GATA3 ?) and podocyte-like (WT1 ?) cells with higher differentiation efficiency than ADSCs in the decellularized scaffolds. Comparatively, this phenomenon was not observed in induced intermediate mesoderm cells cultured in vitro. CONCLUSION: In this study, we demonstrated that intermediate mesoderm cells could be induced from ADSCs and that they could differentiate well after cocultured with decellularized scaffolds.
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GRID-BASED METHODS FOR LINEARLY EQUALITY CONSTRAINED OPTIMIZATION PROBLEMS
Feng, Yan,Zhang, Xuesheng,Liu, Liying 한국전산응용수학회 2007 Journal of applied mathematics & informatics Vol.23 No.1
This paper describes a direct search method for a class of linearly constrained optimization problem. Through research we find it can be treated as an unconstrained optimization problem. And with the decrease of dimension of the variables need to be computed in the algorithms, the implementation of convergence to KKT points will be simplified to some extent. Convergence is shown under mild conditions which allow successive frames to be rotated, translated, and scaled relative to one another.
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Grid-based methods for linearly equality constrained optimization problems
YAN FENG,XUESHENG ZHANG,LIYING LIU 한국전산응용수학회 2007 Journal of applied mathematics & informatics Vol.23 No.1
This paper describes a direct search method for a class of linearly constrained optimization problem. Through research we find it can be treated as an unconstrained optimization problem. And with the decrease of dimension of the variables need to be computed in the algorithms, the implementation of convergence to KKT points will be simplified to some extent. Convergence is shown under mild conditions which allow successive frames to be rotated, translated, and scaled relative to one another.
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Urban Flood Resilience Assessment Based on VIKOR-GRA: A Case Study in Chongqing, China
Xiaobo Chen,Zupei Guo,Hengyu Zhou,Xikun Qian,Xuesheng Zhang 대한토목학회 2022 KSCE JOURNAL OF CIVIL ENGINEERING Vol.26 No.9
Flooding has been considered as one of the major challenges of urban hazards resilience assessment. Improving urban flood risk resilience has become a critical issue for city management. However, urban flood assessment models on the resilience perspective are rare. Meanwhile, in the perspective of resilience, the existing studies using the TOPSIS (Technique for Order Preference by Similarity to an Ideal Solution) assessment method for disaster assessment lack consideration of evaluation scenarios located in the midpoint of positive and negative ideal solutions. To address these issues, this study establishes an urban flood disaster resilience assessment model, selects indicators according to the TOSE (Technical, Organizational, Social and Economic) framework, ranks cities through the VIKOR-GRA (VlseKriterijumska Optimizacija I Kompromisno Resenje, Grey Relational Analysis) method, and proposes measures to improve urban disaster resilience through the resilience assessment. Chongqing is taken as an example in this study to verify the feasibility and effectiveness of the proposed model, and practical management opinions are presented to improve flood resilience in these cities. Through the analysis of actual cases, it can be seen that the model has good applicability and can better reflect the actual situation. The knowledge of flood resilience assessment methods is of particular value to policy makers, researchers and industry professionals in assessing potential risks and recognizing the importance of flood prevention mechanisms.
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