http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
Membrane surface charge and morphological and mechanical properties of young and old erythrocytes
Xing-Yao Chen,Yao-Xiong Huang,Wen-jing Liu,Zhi-jian Yuan 한국물리학회 2007 Current Applied Physics Vol.7 No.s1
ditions were studied as a function of cell age. The young and old cells were separated from fresh rabbit blood by using Percoll densitygradients. A novel multi-dimensional microscope was employed to perform real-time, non-invasivein situmeasurements on the mem-brane bending elastic modulus and the cell shape and size. A phase-analysis micro-electrophoresis laser scattering technique was usedto measure the surface charge density. The results show that the membrane Zeta potential of red blood cells is reduced when they become.
Chen, Si-Ying,Hu, Sa-Sa,Dong, Qian,Cai, Jiang-Xia,Zhang, Wei-Peng,Sun, Jin-Yao,Wang, Tao-Tao,Xie, Jiao,He, Hai-Rong,Xing, Jian-Feng,Lu, Jun,Dong, Ya-Lin Asian Pacific Journal of Cancer Prevention 2013 Asian Pacific journal of cancer prevention Vol.14 No.10
Background: Breast cancer is a common malignant tumor which affects health of women and multidrug resistance (MDR) is one of the main factors leading to failure of chemotherapy. This study was conducted to establish paclitaxel-resistant breast cancer cell line and nude mice models to explore underlying mechanisms of MDR. Methods: The breast cancer drug-sensitive cell line MCF-7 (MCF-7/S) was exposed in stepwise escalating paclitaxel (TAX) to induce a resistant cell line MCF-7/TAX. Cell sensitivity to drugs and growth curves were measured by MTT assay. Changes of cell morphology and ultrastructure were examined by optical and electron microscopy. The cell cycle distribution was determined by flow cytometry. Furthermore, expression of proteins related to breast cancer occurrence and MDR was tested by immunocytochemistry. In Vivo, nude mice were injected with MCF-7/S and MCF-7/TAX cells and weights and tumor sizes were observed after paclitaxel treatment. In addition, proteins involved breast cancer and MDR were detected by immunohistochemistry. Results: Compared to MCF-7/S, MCF-7/TAX cells had a higher resistance to paclitaxel, cross-resistance and prolonged doubling time. Moreover, MCF-7/TAX showed obvious alterations of ultrastructure. Estrogen receptor (ER) expression was low in drug resistant cells and tumors while expression of human epidermal growth factor receptor 2 (HER2) and Ki-67 was up-regulated. P-glycoprotein (P-gp), lung resistance-related protein (LRP) and glutathione-S-transferase-${\pi}$ (GST-${\pi}$) involved in the MDR phenotype of resistant cells and tumors were all overexpressed. Conclusion: The underlying MDR mechanism of breast cancer may involve increased expression of P-gp, LRP and GST-${\pi}$.
Li, Chen-Long,Chang, Liang,Guo, Lin,Zhao, Dan,Liu, Hui-Bin,Wang, Qiu-Shi,Zhang, Ping,Du, Wen-Zhong,Liu, Xing,Zhang, Hai-Tao,Liu, Yang,Zhang, Yao,Xie, Jing-Hong,Ming, Jian-Guang,Cui, Yu-Qiong,Sun, Ying Asian Pacific Journal of Cancer Prevention 2014 Asian Pacific journal of cancer prevention Vol.15 No.23
Background: ${\beta}$-elemene, extracted from herb medicine Curcuma wenyujin has potent anti-tumor effects in various cancer cell lines. However, the activity of ${\beta}$-elemene against glioma cells remains unclear. In the present study, we assessed effects of ${\beta}$-elemene on human glioma cells and explored the underlying mechanism. Materials and Methods: Human glioma U87 cells were used. Cell proliferation was determined with MTT assay and colony formation assay to detect the effect of ${\beta}$-elemene at different doses and times. Fluorescence microscopy was used to observe cell apoptosis with Hoechst 33258 staining and change of glioma apoptosis and cell cycling were analyzed by flow cytometry. Real-time quantitative PCR and Western-blotting assay were performed to investigated the influence of ${\beta}$-elemene on expression levels of Fas/FasL, caspase-3, Bcl-2 and Bax. The experiment was divided into two groups: the blank control group and ${\beta}$-elemne treatment group. Results: With increase in the concentration of ${\beta}$-elemene, cytotoxic effects were enhanced in the glioma cell line and the concentration of inhibited cell viability ($IC_{50}$) was $48.5{\mu}g/mL$ for 24h. ${\beta}$-elemene could induce cell cycle arrest in the G0/G1 phase. With Hoechst 33258 staining, apoptotic nuclear morphological changes were observed. Activation of caspase-3,-8 and -9 was increased and the pro-apoptotic factors Fas/FasL and Bax were upregulated, while the anti-apoptotic Bcl-2 was downregulated after treatment with ${\beta}$-elemene at both mRNA and protein levels. Furthermore, proliferation and colony formation by U87 cells were inhibited by ${\beta}$-elemene in a time and does-dependent manner. Conclusions: Our results indicate that ${\beta}$-elemene inhibits growth and induces apoptosis of human glioma cells in vitro. The induction of apoptosis appears to be related with the upregulation of Fas/FasL and Bax, activation of caspase-3,-8 and -9 and downregulation of Bcl-2, which then trigger major apoptotic cascades.
Liang-Yao Chen,Su-Xing Pan,Yun-Fei Wu,Lai Wei,Yu-Xiang Zheng,You-Yuan Zhao,De-Wang Ma 한국물리학회 2008 THE JOURNAL OF THE KOREAN PHYSICAL SOCIETY Vol.53 No.4
We have investigated the probing beam transmitance due to the photon-induced anisotropy effect in the bacteriorhodopsin/polymer composite film(bR/PC film) by using the probing-pumping beam method under different laser wavelengths. By using a theoretical simulation, we give the characteristics of the birefringence Δn and the dichroism ΔD for various wavelengths of the probing and the pumping beams.
Ping Yao,Jun Zhang,Tieling Xing,Guo-Qiang Chen,Ran Tao,추광호 한국공업화학회 2018 Journal of Industrial and Engineering Chemistry Vol.58 No.-
This study focused on the green synthesis of silver nanoparticles (AgNPs) using grape seed extract and their use for the catalytic degradation of a hazardous dye. The reaction temperature for the synthesis had great impacts to the properties of AgNPs and thereby, contributed to their activity for reductive decomposition of Direct Orange 26 by NaBH4. The elevated temperature made silver particles grow bigger and so reduced the effectiveness of surface catalysis. This was evidenced by the decrease in the reaction rate of AgNPs. The biosynthesis of AgNPs below 40 °C had no negative effect on the degradation of Direct Orange 26.
Yang Yingying,Chen Jian,Gao Qiqian,Feng Yu,Xing Fei,Yao Man 한국물리학회 2022 Current Applied Physics Vol.34 No.-
Two-dimensional layered Ti3C2, one representative MXene, is notable as promising cathode catalyst for rechargeable lithium-oxygen (Li–O2) batteries. Using first-principles calculations, we construct cathode electrochemical interface catalytic model to simulate the structural evolution during discharging and charging processes, and the calculated ORR, OER and TOT overpotentials are used to quantitatively assess the catalytic activity of Ti3C2 MXene with and without O, F and OH functional groups. Interestingly, we find that the catalytic activity follows such a trend: Ti3C2O2>Ti3C2F2>Ti3C2(OH)2>Ti3C2, which suggests that O-terminated Ti3C2 MXene has great advantages and potentiality for catalyzing ORR and OER in Li–O2 batteries. This is caused by Ti3C2O2 surface shows stronger oxidation capability toward O22 compared to Ti3C2F2, Ti3C2(OH)2 and Ti3C2. The present study may provide a guideline to accelerate ORR and OER reactions of Ti3C2 MXene as cathode catalyst in Li–O2 batteries, with O-terminated group being taken into consideration.
Huilai Liu,Minshu Cui,Yao Liu,Defeng Kong,Zhihao Li,Rohan Weerasooriya,Xing Chen 한국공업화학회 2023 Journal of Industrial and Engineering Chemistry Vol.125 No.-
Sulfamethoxazole (SMX) is a widely used antibiotic drug in medical applications resulting in its ubiquityin water and wastewater. Most of the treatment processes are inefficient in destroying SMX in water. Theheterogeneous electro-Fenton (EF)process shows promise in the non-selective degradation of antibioticdrugs in water and wastewater. Fe2O3/MXene-x (x is the ferric ion loading) was fabricated on 2DMXene carriers by hydrothermal method. The Fe2O3/MXene-x substrates were characterized by electronmicroscopic, X-ray, and molecular spectroscopic methods. Degradative products of SMX were identifiedby free radical quenching and LC-MS measurements. Electron micrographs show that Fe2O3 particulatesare uniformly distributed on MXene nanosheets. Fe2O3/MXene-x coated graphite was used as a cathodewith titanium anode for in situ generation of H2O2 required to produce free radicals (e.g. OH and O2 – ) todestroy SMX. Three possible SMX degradation routes by the electro-Fenton process were proposed. SMXand intermediates are eventually mineralized as CO2 and H2O. The new electrocatalyst shows reducedmetal ions leaching and good stability in repeated use cycles. This work offers a new electro-Fentonmethod to destroy antibiotic drugs in water and wastewater.
Dynamic and static properties of sandwich-like graphene-reinforced composite plate
Min Sun,Wen-xing Lu,Minghui Yao,Jianen Chen 대한기계학회 2023 JOURNAL OF MECHANICAL SCIENCE AND TECHNOLOGY Vol.37 No.6
A graphene-reinforced composite plate (GRCP) with a sandwich-like structure is proposed. The nonlinear mechanical characteristics of the sandwich-like GRCP are investigated and compared to those of functionally graded and uniform GRCPs. The modified HalpinTsai model is employed to estimate the material parameters, and the Hamilton principle is used to derive the governing equation for the composite plates. The effects of the graphene nanoplatelet (GPL) distribution patterns, weight fraction, and the number of layers on the static and dynamic nonlinear responses of the plates are investigated. The results show that the various GPL distribution patterns have different enhancement effects on plates. Compared with the graded and uniform distribution patterns, the sandwich-like distribution pattern has significant advantages in terms of anti-vibration and anti-bending properties. Furthermore, it is found that the stresses of the sandwich-like GRCPs are discontinuous, there exist stress mutation phenomena between the surface layers and the pure matrix layer.
( Jia-yi Dou ),( Yu-chen Jiang ),( Zhong-he Hu ),( Kun-chen Yao ),( Ming-hui Yuan ),( Xiao-xue Bao ),( Mei-jie Zhou ),( Yue Liu ),( Zhao-xu Li ),( Li-hua Lian ),( Ji-xing Nan ),( Yan-ling Wu ) 한국응용약물학회 2022 Biomolecules & Therapeutics(구 응용약물학회지) Vol.30 No.3
The present study focused on the potential mechanism of betulin (BT), a pentacyclic triterpenoid isolated from the bark of white birch (Betula pubescens), against chronic alcohol-induced lipid accumulation and metaflammation. AML-12 and RAW 264.7 cells were administered ethanol (EtOH), lipopolysaccharide (LPS) or BT. Male C57BL/6 mice were fed Lieber-DeCarli liquid diets containing 5% EtOH for 4 weeks, followed by single EtOH gavage on the last day and simultaneous treatment with BT (20 or 50 mg/kg) by oral gavage once per day. In vitro, MTT showed that 0-25 mM EtOH and 0-25 μM BT had no toxic effect on AML-12 cells. BT could regulate sterolregulatory-element-binding protein 1 (SREBP1), lipin1/2, P2X7 receptor (P2X7r) and NOD-like receptor family, pyrin domains-containing protein 3 (NLRP3) expressions again EtOH-stimulation. Oil Red O staining also indicated that BT significantly reduced lipid accumulation in EtOH-stimulated AML-12 cells. Lipin1/2 deficiency indicated that BT might mediate lipin1/2 to regulate SREBP1 and P2X7r expression and further alleviate lipid accumulation and inflammation. In vivo, BT significantly alleviated histopathological changes, reduced serum alanine aminotransferase (ALT) and aspartate aminotransferase (AST) and triglyceride (TG) levels, and regulated lipin1/2, SREBP1, peroxisome proliferator activated receptor α/γ (PPARα/γ) and PGC-1α expression compared with the EtOH group. BT reduced the secretion of inflammatory factors and blocked the P2X7r-NLRP3 signaling pathway. Collectively, BT attenuated lipid accumulation and metaflammation by regulating the lipin1/2-mediated P2X7r signaling pathway.
Establishing a Nomogram for Stage IA-IIB Cervical Cancer Patients after Complete Resection
Zhou, Hang,Li, Xiong,Zhang, Yuan,Jia, Yao,Hu, Ting,Yang, Ru,Huang, Ke-Cheng,Chen, Zhi-Lan,Wang, Shao-Shuai,Tang, Fang-Xu,Zhou, Jin,Chen, Yi-Le,Wu, Li,Han, Xiao-Bing,Lin, Zhong-Qiu,Lu, Xiao-Mei,Xing, H Asian Pacific Journal of Cancer Prevention 2015 Asian Pacific journal of cancer prevention Vol.16 No.9
Background: This study aimed to establish a nomogram by combining clinicopathologic factors with overall survival of stage IA-IIB cervical cancer patients after complete resection with pelvic lymphadenectomy. Materials and Methods: This nomogram was based on a retrospective study on 1,563 stage IA-IIB cervical cancer patients who underwent complete resection and lymphadenectomy from 2002 to 2008. The nomogram was constructed based on multivariate analysis using Cox proportional hazard regression. The accuracy and discriminative ability of the nomogram were measured by concordance index (C-index) and calibration curve. Results: Multivariate analysis identified lymph node metastasis (LNM), lymph-vascular space invasion (LVSI), stromal invasion, parametrial invasion, tumor diameter and histology as independent prognostic factors associated with cervical cancer survival. These factors were selected for construction of the nomogram. The C-index of the nomogram was 0.71 (95% CI, 0.65 to 0.77), and calibration of the nomogram showed good agreement between the 5-year predicted survival and the actual observation. Conclusions: We developed a nomogram predicting 5-year overall survival of surgically treated stage IA-IIB cervical cancer patients. More comprehensive information that is provided by this nomogram could provide further insight into personalized therapy selection.