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- 저자 : Xin Miao Tan (검색결과 2 건)
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Honglin Xu,Haifeng Miao,Guanghong Chen,Guoyong Zhang,Yue Hua,Yuting Wu,Tong Xu,Changlei Hu,Mingjie Pang,Leyi Tan,Xin Han,Bin Liu,Yingchun Zhou 고려인삼학회 2023 Journal of Ginseng Research Vol.47 No.6
Background: Myocardial fibrosis post-myocardial infarction (MI) can induce maladaptive cardiacremodeling as well as heart failure. Although 20(S)-ginsenoside Rg3 (Rg3) has been applied to cardiovasculardiseases, its efficacy and specific molecular mechanism in myocardial fibrosis are largely unknown. Herein, we aimed to explore whether TGFBR1 signaling was involved in Rg3's anti-fibrotic effectpost-MI. Methods: Left anterior descending (LAD) coronary artery ligation-induced MI mice and TGF-b1-stimulated primary cardiac fibroblasts (CFs) were adopted. Echocardiography, hematoxlin-eosin andMasson staining, Western-blot and immunohistochemistry, CCK8 and Edu were used to study the effectsof Rg3 on myocardial fibrosis and TGFBR1 signaling. The combination mechanism of Rg3 and TGFBR1 wasexplored by surface plasmon resonance imaging (SPRi). Moreover, myocardial Tgfbr1-deficient mice andTGFBR1 adenovirus were adopted to confirm the pharmacological mechanism of Rg3. Results: In vivo experiments, Rg3 ameliorated myocardial fibrosis and hypertrophy and enhanced cardiacfunction. Rg3-TGFBR1 had the 1.78 10 7 M equilibrium dissociation constant based on SPRi analysis,and Rg3 inhibited the activation of TGFBR1/Smads signaling dose-dependently. Cardiac-specific Tgfbr1knockdown abolished Rg3's protection against myocardial fibrosis post-MI. In addition, Rg3 downregulatedthe TGF-b1-mediated CFs growth together with collagen production in vitro through TGFBR1signaling. Moreover, TGFBR1 adenovirus partially blocked the inhibitory effect of Rg3. Conclusion: Rg3 improves myocardial fibrosis and cardiac function through suppressing CFs proliferationalong with collagen deposition by inactivation of TGFBR1 pathway.
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Sheng Hsiung Chiu,Shi Li Xiao,Xin Miao Tan,Tzu Yu Lin,Helen Yang 한국유통과학회 2017 KODISA ICBE (International Conference on Business Vol.2017 No.-
The purpose of this paper is to investigate the CO₂ reduction performance on industry level in Taiwan after the renewable development act that enacted in 2009. We observe that CO₂ reduction performance has risen slightly due to the effectiveness of energy-saving technologies and low-carbon energy structures under the growth scale of Taiwan’s economy in the meanwhile. It is noticed that the target of GHG reduction in Taiwan for 2030 will be controlled at 20% off compared to their 2005 levels, in accordance of the COP21 that made an appeal to their member nation to submit a reduction target about GHG (CO₂) emission. Therefore, to realize the historical situation of CO₂ emission with the consideration of economic growth has been brought to the attention of Taiwanese government for policy planning on mitigating CO₂ emission on either national level or industry level. We can draw several policy implications from the evaluation results. First, we suggest that the government should pay more attention on industrial sectors because they relative underperformed in terms of their CO₂ reduction behavior in the viewpoint of meta-frontier. Second, it is noted that electricity will be the main part of the energy consumption structure. A low-carbon electricity supply portfolio is necessary for decreasing CO₂ emissions. It may not practical, only that expanding the capacity of renewable energies becomes antidote.
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