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- 저자 : Xiaotian Huang (검색결과 4 건)
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Nonlinear Anti-swing Control of Underactuated Tower Crane Based on Improved Energy Function
Huaitao Shi,Jianqi Huang,Xiaotian Bai,Xiang Huang,Jie Sun 제어·로봇·시스템학회 2021 International Journal of Control, Automation, and Vol.19 No.12
The control system of tower crane exhibits strong nonlinearity in the process of control execution, which is prone to the problems of inaccurate positioning control of the payload and difficult anti-swing control. Aiming at the problems, this paper proposes a control law based on improved energy coupling analysis for suppressing the payload swing in the tower cranes. A three-dimensional dynamic model of tower crane system with considering friction is established, and an improved energy coupling signal is designed. The coupling relationship of trolley movement and payload swing, jib rotation and payload swing are considered, then a nonlinear anti-swing controller is established in order to reduce the swing. The closed-loop stability of the system with the controller is verified by the Lyapunov method and LaSalle invariance principle, simulations and experimental analyses are performed to verify the controller performance. The control performance of the controller is compared with other classic and typical current control methods, and the proposed controller outperformed other controllers. The anti-swing controller proposed in this paper has accurate positioning, and can achieve precise control when the payload is transported, reaching the set target position in a little time and eliminating residual swing angle. Meanwhile the proposed controller has a good control robustness, which can restore stability in around a very short time when the rope length and payload mass of the system’s inherent property are changed and external interference is added. In addition, when different target position parameters are uncertain, the proposed control law has good robust performance.
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Jiangcong Zhou,Yiqing Lai,Na Lin,Xiaotian Huang,Yu Chen,Yao Yao,Bo Wang 성균관대학교(자연과학캠퍼스) 성균나노과학기술원 2019 NANO Vol.15 No.01
Currently, the poor stability of inorganic perovskite CsPbX3 (X = Cl, Br, I) nanocrystals restricts their practical application in optoelectronic devices. Therefore, improving the stability of this material remains an urgent task for most researchers. In this study, incorporation of CsPbBr3 nanocrystals into porous AlO(OH) matrices through simple in situ synthesis was demonstrated to be an efficient approach for improving the nanocrystal stability. X-ray diffraction (XRD) revealed that the as-obtained product was composed of cubic CsPbBr3 nanocrystals and orthorhombic AlO(OH) compounds. In addition, transmission electron microscopy (TEM) revealed that the CsPbBr3 nanocrystals were successfully encapsulated by AlO(OH) matrices. The Brunauer–Emmett–Teller (BET) specific surface area was 234.96 m2 g -1 for AlO(OH) and 60.08 m2 g -1 for the CsPbBr3@AlO(OH) composites. The decrease in surface area could be attributed to the filling of the AlO(OH) pores by the CsPbBr3 nanocrystals. Further, the as-prepared composites showed red-shifted emission at 522 nm and a larger full width at half-maximum (FWHM) as 26 nm, compared with those of the CsPbBr3 nanocrystals with the emission at 517 nm and FWHM as 17 nm. More importantly, the emission intensity preserved 67% of the original value after a storage time of 120 h, but bare CsPbBr3 nanocrystals rapidly degraded within only 1 h in the polar ethanol solution. Finally, a light-emitting diode (LED) device was fabricated by coating the CsPbBr3@AlO(OH) composites and red commercial K2SiF6:Mn4+ phosphors on the surface of a blue InGaN chip, covering 96% of National Television Standards Committee. The results indicate that the obtained composites could be promising luminescent materials for backlit displays.
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( Wenshuo Wang ),( Ye Yang ),( Yiqing Wang ),( Liewen Pang ),( Jiechun Huang ),( Hongyue Tao ),( Xiaotian Sun ),( Chen Liu ) 한국미생물 · 생명공학회 2016 Journal of microbiology and biotechnology Vol.26 No.3
Communication between endothelial cells (ECs) and smooth muscle cells (SMCs) via miR-143/145 clusters is vital to vascular stability. Previous research demonstrates that miR-143/145 released from ECs can regulate SMC proliferation and migration. In addition, a recent study has found that SMCs also have the capability of manipulating EC function via miR-143/145. In the present study, we artificially increased the expression of miR-143/145 in ECs, to mimic a similar change caused by miR-143/145 released by SMCs, and applied untargeted metabolomics analysis, aimed at investigating the consequential effect of miR-143/145 overexpression. Our results showed that miR-143/145 overexpression alters the levels of metabolites involved in energy production, DNA methylation, and oxidative stress. These changed metabolites indicate that metabolic pathways, such as the SAM cycle and TCA cycle, exhibit significant differences from the norm with miR-143/145 overexpression.
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Ting Xu,Xicheng Wang,Ying Xin,Zhenghang Wang,Jifang Gong,Xiaotian Zhang,Yanyan Li,Congcong Ji,Yu Sun,Feilong Zhao,Depei Huang,Yuezong Bai,Jian Li,Lin Shen 대한암학회 2023 Cancer Research and Treatment Vol.55 No.2
Purpose The human epidermal growth factor receptor 2 (HER2) is an established therapeutic target for various kinds of solid tumors. HER2 amplification occurs in approximately 1% to 6% of colorectal cancer. In this study, we aimed to assess the efficacy and safety of trastuzumab in combination with chemotherapy in HER2-positive metastatic colorectal cancer (mCRC). Materials and Methods An open-label, phase II trial (Clinicaltrials.gov: NCT03185988) was designed to evaluate the antitumor activity of trastuzumab and chemotherapy in HER2-positive digestive cancers excluding gastric cancer in 2017. Patients from this trial with HER2-positive, KRAS/BRAF wild-type, unresectable mCRC were analyzed in this manuscript. Eligible patients were treated with trastuzumab (8 mg/kg loading dose and then 6 mg/kg every 3 weeks) and irinotecan (120 mg/m2 days 1 and 8 every 3 weeks). The primary endpoint was the objective response rate. Results Twenty-one HER2-positive mCRC patients were enrolled in this study. Seven patients (33.3%) achieved an objective res-ponse, and 11 patients (52.4%) had stable disease as their best response. The median progression-free survival (PFS) was 4.3 months (95% confidence interval, 2.7 to 5.9). Four of the 21 patients (19.0%) had grade 3 adverse events, including leukopenia, neutropenia, urinary tract infection, and diarrhea. No treatment-related death was reported. Exploratory analyses revealed that high tumor tissue HER2 copy number was associated with better therapeutic response and PFS. Alterations in the mitogen-activated protein kinase pathway, HER2 gene, phosphoinositide 3-kinase/AKT pathway, and cell cycle control genes were potential drivers of trastuzumab resistance in mCRC. Conclusion Trastuzumab combined with chemotherapy is a potentially effective and well-tolerated therapeutic regimen in mCRC with a high HER2 copy number.
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