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Yang Lu,Shuxin Liu,Shujia Zhang,Guangyan Cai,Hongwei Jiang,Huabin Su,Xiaofan Li,Quan Hong,Xueguang Zhang,Xiangmei Chen 한국분자세포생물학회 2011 Molecules and cells Vol.31 No.3
Tissue inhibitor of metalloproteinase-1 (TIMP-1) plays various roles in cell growth in different cell types. However, few studies have focused on TIMP-1’s effect on fibroblast cells. In this study, we investigated the effects of TIMP-1 overexpression on NIH3T3 fibroblast proliferation and potential transduction signaling pathways involved. Overexpression of TIMP-1, by transfection of the pLenti6/ V5-DESTTIMP-1 plasmid, significantly promoted NIH3T3 proliferation as determined by the BrdU array. Neither 5 nor 15 nM GM6001 (matrix metalloproteinase system inhibitor) affected NIH3T3 proliferation, but 45 nM GM6001 inhibited proliferation. TIMP-1 overexpression activated the p-Akt pathway, but not the p-ERK or p-p38 pathway. In TIMP-1-transfected cells, cyclinD1 was upregulated and p21CIP1 and p27^(KIP1) were downregulated, which promoted cell entry into the S and G2/M phases. The PI3-K inhibitor LY294002 abolished the TIMP-1-induced effects. Overexpression of intracellular TIMP-1 stimulated NIH3T3 fibroblast proliferation in a matrix metalloproteinase (MMP)-independent manner by activating the p-Akt pathway and related cell cycle progression.
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Wenming Zhang,Xiaofan Lu,Jiaqi Chang,Genmin Tian,Lianfeng Xia 국제구조공학회 2021 Structural Engineering and Mechanics, An Int'l Jou Vol.80 No.6
Suspension bridges bear large eccentric live loads in rush hours when most vehicles travel in one direction on the left or right side of the bridge. With the increasing number and weight of vehicles and the girder widening, the eccentric live load effect on the bridge behavior, including bending and distortion of the main girder, gets more pronounced, even jeopardizing bridge safety. This study proposes an analytical algorithm based on multi-catenary theory for predicting the suspension bridge responses to eccentric live load via the nonlinear generalized reduced gradient method. A set of governing equations is derived to solve the following unknown values: the girder rigid-body displacement in the longitudinal direction; the horizontal projection lengths of main cable’s segments; the parameters of catenary equations and horizontal forces of the side span cable segments and the leftmost segments of middle span cables; the suspender tensions and the bearing reactions. Then girder’s responses, including rigid-body displacement in the longitudinal direction, deflections, and torsion angles; suspenders’ responses, including the suspender tensions and the hanging point displacements; main cables’ responses, including the horizontal forces of each segment; and the longitudinal displacement of the pylons’ tower top under eccentric load can be calculated. The response of an exemplar suspension bridge with three spans of 168, 548, and 168 m is calculated by the proposed analytical method and the finite element method in two eccentric live load cases, and their results prove the former’s feasibility. The nonuniform distribution of the live load in the lateral direction is shown to impose a greater threat to suspension bridge safety than that in the longitudinal direction, while some other specific features revealed by the proposed method are discussed in detail.
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