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      저자 : Xiangji Yan (검색결과 1 건)
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        Tunable paclitaxel release carrier using diselenide-disulfide balance as regulator

        Jingwen Xu,Xiangji Yan,Yue Zhang,Kangsheng Tu,Wen Shen,Zhaoqing Tian,Guoliang Li,Wei Zhao,Mingzhen Zhang 한국공업화학회 2022 Journal of Industrial and Engineering Chemistry Vol.109 No.-

        There are many reasons that lead to the failure of cancer chemotherapy, such as uncontrolled drugrelease, low drug utilization, and severe side effects. To overcome these obstacles, two kinds of thermaland redox-responsive copolymers with multiple diselenide/disulfide linkages, polyethylene glycol -altdiselenodipropionate/disulfhydryldipropionate-b-poly(N-isopropylacrylamide) (abbreviated as PEG-alt-DSeDP-b-PNIPAM and PEG-alt-DSDP-b-PNIPAM) were fabricated by alternative esterification and followingatom transfer radical polymerization. Afterward, these prepared copolymers were mixed in line withthe mass ratio of 8:0, 5:3, 3:5, 0:8 (denoted as S1, S2, S3, and S4, respectively), and self-assembled withpaclitaxel (PTX) to obtain PTX-loaded S1, S2, S3, and S4 nanomicellar assemblies, aiming to realize PTXtunable release using diselenide-disulfide balance as regulator. The chemical structures of these twocopolymers were characterized by gel permeation chromatography, indicating eight diselenide/disulfidelinkages and eight PEG units were contained in these copolymers. Moreover, the thermal-responsiveproperty was detected by UV–vis spectroscopy, meanwhile, the redox responsiveness was observed byTEM in the presence of 10 mM glutathione. We found that 76.90% of PTX was released from S1 nanomicelleswithin 23 h. In contrast, this percentage decreased to 64.53% for S4 nanomicelles even the incubationtime prolonged, indicating explosive and slow release behaviors of S1 and S4 nanomicelles,respectively. In addition, gradually decreased fluorescence intensity around the cellular nucleus wasoccurred from S1 to S4 orderly, which was consistent with cellular uptake and in vivo anti-tumor experiments. Taken together, this work not only provides a strategy for tunable PTX release, but also improveseffectiveness of PTX in cancer treatment.

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