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- 저자 : Xiangchao Ding (검색결과 3 건)
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Guang Li,Bo Wang,Xiangchao Ding,Xinghua Zhang,Jian Tang,Huiqing Lin 생화학분자생물학회 2021 Experimental and molecular medicine Vol.53 No.-
Extracellular vesicles (EVs) can be used for intercellular communication by facilitating the transfer of miRNAs from one cell to a recipient cell. MicroRNA (miR)-210-3p is released into the blood during sepsis, inducing cytokine production and promoting leukocyte migration. Thus, the current study aimed to elucidate the role of plasma EVs in delivering miR-210-3p in sepsis-inducedacute lung injury (ALI). Plasma EVs were isolated from septic patients, after which the expression of various inflammatory factors was measured using enzyme-linked immunosorbent assay. Cell viability and apoptosis were measured via cell counting kit-8 and flow cytometry. Transendothelial resistance and fluorescein isothiocyanate fluorescence were used to measure endothelial cellpermeability. Matrigel was used to examine the tubulogenesis of endothelial cells. The targeting relationship between miR-210-3p and ATG7 was assessed by dual-luciferase reporter assays. The expression of ATG7 and autophagy-related genes was determined to examine autophagic activation. A sepsis mouse model was established by cecal ligation and puncture (CLP)-induced surgery. The level of miR-210-3p was highly enriched in septic EVs. MiR-210-3p enhanced THP-1 macrophage inflammation, BEAS-2B cell apoptosis, and HLMVEC permeability while inhibiting angiogenesis and cellular activity. MiR-210-3p overexpression reduced ATG7 and LC3II/LC3I expression and increased P62 expression. Improvements in vascular density and autophagosome formation, increased ATG7 expression, and changes in the ratio of LC3II/LC3I were detected, as well as reduced P62 expression, in adenovirusanti-miR-210-3p treated mice after CLP injury. Taken together, the key findings of the current study demonstrate that plasma EVs carrying miR-210-3p target ATG7 to regulate autophagy and inflammatory activation in a sepsis-induced ALI model.
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PRESSURE DROP CHARACTERISTICS OF R410A-OIL MIXTURE FLOW BOILING IN SMALL SMOOTH TUBES
Gao, Yifeng,Deng, Bin,Ding, Guoliang,Hu, Haitao,Huang, Xiangchao The Society of Air-Conditioning and Refrigerating 2010 International Journal Of Air-Conditioning and Refr Vol.18 No.2
This study presents experimental frictional pressure drop for R410A/oil mixture flow boiling in small horizontal smooth tubes with inside diameters of 4.18mm and 2.0 mm. Experimental conditions cover nominal oil concentrations from 0 to 5%. The test results show that the presence of oil enhances two-phase frictional pressure drop about 0-120% and 0-90% at present tee conditions for 4.18mm I.D. smooth tube and 2.0mm I.D. smooth tube, respectively, and the enhanced effect is more evident at higher vapor qualities where the local oil concentrations are higher. A new correlation to predict the local frictional pressure drop of R410A/oil mixture flow boiling inside conventional size and small smooth tubes is developed based on local properties of refrigerant-oil mixture, and the experimental data of 4.18mm I.D. and 2.0mm I.D. smooth tubes and that of 6.34mm I.D. smooth tube (Hu et al., 2008) are well-correlated with the new correlation.
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PRESSURE DROP CHARACTERISTICS OF R410A-OIL MIXTURE FLOW BOILING IN SMALL SMOOTH TUBES
YIFENG GAO,BIN DENG,GUOLIANG DING,HAITAO HU,XIANGCHAO HUANG 대한설비공학회 2010 International Journal of Air-Conditioning and Refr Vol.18 No.2
This study presents experimental frictional pressure drop for R410A/oil mixture flow boiling in small horizontal smooth tubes with inside diameters of 4.18 mm and 2.0 mm. Experimental conditions cover nominal oil concentrations from 0 to 5%. The test results show that the presence of oil enhances two-phase frictional pressure drop about 0–120% and 0–90% at present test conditions for 4.18 mm I.D. smooth tube and 2.0 mm I.D. smooth tube, respectively, and the enhanced effect is more evident at higher vapor qualities where the local oil concentrations are higher. A new correlation to predict the local frictional pressure drop of R410A/oil mixture flow boiling inside conventional size and small smooth tubes is developed based on local properties of refrigerant–oil mixture, and the experimental data of 4.18 mm I.D. and 2.0 mm I.D. smooth tubes and that of 6.34 mm I.D. smooth tube (Hu et al., 2008) are well-correlated with the new correlation.
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