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RISS 인기검색어
- 검색키워드
- 저자 : Wu-Qing OuYang (검색결과 3 건)
- 무료
- 기관 내 무료
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Smooth model of blasting seismic wave signal denoising based on two-stage denoising algorithm
Sun Miao,Wu Li,Li Chunjun,Yuan Qing,Zhou Yuchun,Ouyang Xu 한국자원공학회 2020 Geosystem engineering Vol.23 No.4
In this paper, a two-stage denoising algorithm is proposed. Complementary ensemble empirical mode decomposition based on permutation entropy (CEEMD-PE) is carried out for the noisy monitoring signal in the first stage. Several denoising models are established according to the intrinsic mode function obtained by CEEMD-PE. An objective function considers both the smoothness of the denoising model and the similarity between the denoising model and the noisy monitoring signal is established, and the second stage denoising is realized by solving the objective function. The denoising model corresponding to the optimal solution of the objective function is the smooth denoising model. In order to verify the correctness of the two-stage denoising algorithm, the mixed simulation signal with noise is denoised, and based on the definition of signal-to-noise ratio, the effect of two-stage denoising is calculated. Finally, the algorithm is applied to the actual blasting seismic signal denoising processing. It is found that the proposed algorithm can not only reduce the noise interference but also retain the real part of the original signal while filtering the noise.
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Kinetin inhibits apoptosis of aging spleen cells induced by D-galactose in rats
Mengyun Li,Wu-Qing OuYang,Xiaoli Wu,Yin Zheng,Yunpeng Wei,Lei An 대한수의학회 2014 Journal of Veterinary Science Vol.15 No.3
Kinetin (Kn) is a cytokinin growth factor that exertsseveral anti-aging and antioxidant effects on cells andorgans. To investigate the mechanism underlying apoptoticevents in aging cells induced by D-galactose (D-gal), weexamined the effect of Kn delivered via nuchalsubcutaneous injection on D-gal-induced aging andapoptosis in rats. Our results showed that interleukin (IL)-2levels and mitochondrial membrane potential (Δ Ψ m) weredecreased by Kn in aging rats while IL-6 production andapoptosis increased. In addition, the expression ofanti-apoptotic Bcl-2 was low while that of Bax was high inthe aging group. After treated with Kn, compared withaging group, there showed obvious difference in Kn groupwith elevated IL-2, proliferation index, Bcl-2, Δ Ψ m anddecreased IL-6 and Bax in splenic lymphocyte. Based onthese results, we concluded that Kn can effectively protectthe rat spleen from aging, apoptosis, and atrophy.
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A Combination of a Microemulsion and a Phospholipid Complex for Topical Delivery of Oxymatrine
Fa-Hao Cao,Wu-Qing OuYang,Yan-Ping Wang,Peng-Fei Yue,Shu-Peng Li 대한약학회 2011 Archives of Pharmacal Research Vol.34 No.4
Oxymatrine (OMT), a water-soluble drug, has a very low oral bioavailability because of its low membrane permeability and its biotransformation in the gastrointestinal tract. Formulated as an oxymatrine-phospholipid complex (OMT-PLC) can improve the lipid solubility and effectiveness of OMT. The purpose of this study was to explore the utility of the combination of a microemulsion and an OMT-PLC as a topical delivery vehicle for enhancing the absorption and efficacy of OMT. The solubility of OMT-PLC was determined and phase diagrams of microemulsions were constructed. Various microemulsion formulations were developed and characterized by their physicochemical properties, and their in vitro and in vivo permeability through skin. An optimal microemulsion (ME4), which presented as spherical droplets and consisted of 10.0% OMT-PLC, 8.0% isopropyl myristate, 30.0% Cremophor RH40/polyethylene glycol 400 (1:1) and 52.0% water, was selected. It possessed an average droplet size of 32.4 nm, a low viscosity of 113.7 mPa · s, and a high cloud point of 88°C. Compared to the control solution, ME4 provided better skin permeability in vitro and a higher retention ratio of OMT in skin in vivo. Moreover, ME4 significantly enhanced the antiproliferative activity of OMT on scar fibroblasts. These results indicate that the combination of a microemulsion and a phospholipid complex represents an effective vehicle for topical delivery of OMT.
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