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      • KCI등재

        Delayed Analysis of Hydrogen-Methane Breath Samples

        Marjolein Willemsen,Kristel Van De Maele,Yvan Vandenplas 대한소아소화기영양학회 2022 Pediatric gastroenterology, hepatology & nutrition Vol.25 No.1

        Purpose: Hydrogen-methane breath tests are used to diagnose carbohydrate malabsorption and small intestinal bacterial overgrowth. The COVID-19 pandemic has driven the modification of procedures as breath tests are potentially aerosol-generating procedures. We assessed the effect of delayed analysis of breath samples, facilitating the at-home performance of breath testing. Methods: Children provided two breath samples at every step of the lactose breath test. The samples were brought back to the clinic, and one set of samples was analyzed immediately. The second set was stored at room temperature and analyzed 1-4 days later. Results: Out of the 73 “double” lactose breath tests performed at home, 33 (45.8%) were positive. The second samples were analyzed 20 to 117 hours after the first samples (41.7±24.3 hours). There was no significant difference in the hydrogen concentration between the first and second sets (Z=0.49, p=0.62). This was not the case for methane, which had a significantly higher concentration in the second breath samples (Z=7.6). Conclusion: Expired hydrogen levels remain stable in plastic syringes if preserved at room temperature for several days. On the other hand, the delayed analysis of methane appeared to be less reliable. Further research is needed to examine the impact of delayed analysis on methane and hydrogen concentrations.

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        Trochanteric Fixation Nail with Helical Blade Compared with Femoral Neck Screw for Operative Treatment of Intertrochanteric Femoral Fractures

        J.P.H. van Leur,T.S.C. Jakma,S.P Willemsen,B.J. Punt 대한고관절학회 2019 Hip and Pelvis Vol.31 No.1

        Purpose: This study was performed to compare outcomes of the Trochanteric Fixation Nail (TFN) with a helical blade versus TFN with a femoral neck screw for the treatment of intertrochanteric femoral fractures. Materials and Methods: A single center, retrospective cohort study. Patients (>18 years of age) with an intertrochanteric femoral fracture, who were operated on between January 1, 2012 and December 31, 2016 were included. Primary and secondary outcome measures were cut-out rate and intervention variables, respectively. Data from X-ray examinations and patient medical files were collected and analyzed. The chi-square test or Student’s t-test were used for statistical analysis. Results: A total of 631 patients were surgically treated for an intertrochanteric femoral fracture. Of this group, 239 patients (37.9%) were treated with a TFN with helical blade and 392 patients (62.1%) with a TFN with femoral neck screw. There were no statistically significant differences between the baseline characteristics of both groups. A total of 17 (2.7%) cut-outs were recorded, with no statistically significant difference between the two groups (P=0.19). Additionally, there were no statistically significant differences in the secondary outcome measures between the two groups. Conclusion: There are no statistically significant differences in primary and secondary outcomes following treatment of intertrochanteric femur fracture with the TFN helical blade or TFN femoral neck screw. These findings suggest that the choice of collum implant for the surgical treatment of intertrochanteric femur fractures cannot be made based on the surgical outcomes of the two implants evaluated here.

      • KCI등재

        Trochanteric Fixation Nail<sup>®</sup> with Helical Blade Compared with Femoral Neck Screw for Operative Treatment of Intertrochanteric Femoral Fractures

        ( J. P. H. Van Leur ),( T. S. C. Jakma ),( S. P Willemsen ),( B. J. Punt ) 대한고관절학회 2019 Hip and Pelvis Vol.31 No.1

        Purpose: This study was performed to compare outcomes of the Trochanteric Fixation Nail (TFN <sup>®</sup>) with a helical blade versus TFN <sup>®</sup> with a femoral neck screw for the treatment of intertrochanteric femoral fractures. Materials and Methods: A single center, retrospective cohort study. Patients (>18 years of age) with an intertrochanteric femoral fracture, who were operated on between January 1, 2012 and December 31, 2016 were included. Primary and secondary outcome measures were cut-out rate and intervention variables, respectively. Data from X-ray examinations and patient medical files were collected and analyzed. The chi-square test or Student’s t-test were used for statistical analysis. Results: A total of 631 patients were surgically treated for an intertrochanteric femoral fracture. Of this group, 239 patients (37.9%) were treated with a TFN <sup>®</sup> with helical blade and 392 patients (62.1%) with a TFN <sup>®</sup> with femoral neck screw. There were no statistically significant differences between the baseline characteristics of both groups. A total of 17 (2.7%) cut-outs were recorded, with no statistically significant difference between the two groups (P=0.19). Additionally, there were no statistically significant differences in the secondary outcome measures between the two groups. Conclusion: There are no statistically significant differences in primary and secondary outcomes following treatment of intertrochanteric femur fracture with the TFN <sup>®</sup> helical blade or TFN <sup>®</sup> femoral neck screw. These findings suggest that the choice of collum implant for the surgical treatment of intertrochanteric femur fractures cannot be made based on the surgical outcomes of the two implants evaluated here.

      • Twin's Birth-Order Differences in Height and Body Mass Index From Birth to Old Age: A Pooled Study of 26 Twin Cohorts Participating in the CODATwins Project

        Yokoyama, Yoshie,Jelenkovic, Aline,Sund, Reijo,Sung, Joohon,Hopper, John L.,Ooki, Syuichi,Heikkilä,, Kauko,Aaltonen, Sari,Tarnoki, Adam D.,Tarnoki, David L.,Willemsen, Gonneke,Bartels, Meike,van B Cambridge University Press 2016 TWIN RESEARCH AND HUMAN GENETICS - Vol.19 No.2

        <P>We analyzed birth order differences in means and variances of height and body mass index (BMI) in monozygotic (MZ) and dizygotic (DZ) twins from infancy to old age. The data were derived from the international CODATwins database. The total number of height and BMI measures from 0.5 to 79.5 years of age was 397,466. As expected, first-born twins had greater birth weight than second-born twins. With respect to height, first-born twins were slightly taller than second-born twins in childhood. After adjusting the results for birth weight, the birth order differences decreased and were no longer statistically significant. First-born twins had greater BMI than the second-born twins over childhood and adolescence. After adjusting the results for birth weight, birth order was still associated with BMI until 12 years of age. No interaction effect between birth order and zygosity was found. Only limited evidence was found that birth order influenced variances of height or BMI. The results were similar among boys and girls and also in MZ and DZ twins. Overall, the differences in height and BMI between first- and second-born twins were modest even in early childhood, while adjustment for birth weight reduced the birth order differences but did not remove them for BMI.</P>

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