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Magnetization Plateaus in Generalized Shastry-Sutherland Models
Keola Wierschem,Pinaki Sengupta 한국물리학회 2013 THE JOURNAL OF THE KOREAN PHYSICAL SOCIETY Vol.63 No.3
We study an anisotropic Heisenberg antiferromagnet with ferromagnetic transverse spin exchangeusing exact quantum Monte Carlo methods. Such a model is relevant to a class of rare earthtetraboride materials that display a range of magnetization plateaus under applied magnetic field. The layered arrangement of magnetic ions in these materials is topologically equivalent to theShastry-Sutherland lattice. In this frustrated geometry, we study the interplay of next-nearestneighbor interactions in stabilizing a plateau at half the saturation magnetization (or 1/2 plateau). We also show hysteresis-like behavior at the onset of the 1/3 plateau.
Measuring Mechanical Cell Properties of Paclitaxel-treated MCF-7 Cells in a Monolayer
Suhyang LEE,Gayeon KIM,Donghee JUNG,Khawaja Muhammad Imran BASHIR,Santanu Kumar BASU,Mangi CHO,Andreas WIERSCHEM 한국생물공학회 2021 한국생물공학회 학술대회 Vol.2021 No.10
Cytoskeleton is the key element of cell proliferation. It regulates the size and shape of the cells, and it allows cell growth, division and locomotion. Cytoskeleton-affecting anti-cancer drugs work with interfering the proliferation by polymerization or depolymerization of cytoskeleton. To elucidate the mechanical impact of these drugs on cancer cells, we have measured the viscoelastic cell properties of MCF-7 cells in a monolayer with a ‘narrow gap rheometer’ after treatment with hydroxyurea and paclitaxel. Paclitaxel impedes depolymerization of the microtubule, which may have an impact on the cell mechanics. It acts cytotoxically at sufficiently high concentrations during the division cycle. To study living cells, we prevent the cells from division by using hydroxyurea, which arrests the cell cycle. To access the cell mechanics on the cell scale, we have improved the precision of commercial rheometers by about two orders of magnitude. Here, we focus on the impact of paclitaxel on the storage and loss moduli at different concentrations.