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- 저자 : Wenbo Huo (검색결과 2 건)
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Caspase-3 inhibitor inhibits enterovirus D68 production
Wenbo Huo,Jinghua Yu,Chunyu Liu,Ting Wu,Yue Wang,Xiangling Meng,Fengmei Song,Shuxia Zhang,Ying Su,Yumeng Liu,Jinming Liu,Xiaoyan Yu,Shucheng Hua 한국미생물학회 2020 The journal of microbiology Vol.58 No.9
Enterovirus D68 (EVD68) is an emerging pathogen that recently caused a large worldwide outbreak of severe respiratory disease in children. However, the relationship between EVD68 and host cells remains unclear. Caspases are involved in cell death, immune response, and even viral production. We found that caspase-3 was activated during EVD68 replication to induce apoptosis. Caspase-3 inhibitor (Z-DEVDFMK) inhibited viral production, protected host cells from the cytopathic effects of EVD68 infection, and prevented EVD68 from regulating the host cell cycle at G0/G1. Meanwhile, caspase-3 activator (PAC-1) increased EVD68 production. EVD68 infection therefore activates caspase-3 for virus production. This knowledge provides a potential direction for the prevention and treatment of disease related to EVD68.
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Junzhou Huo,Hanyang Wu,Wenbo Ji 대한기계학회 2020 JOURNAL OF MECHANICAL SCIENCE AND TECHNOLOGY Vol.34 No.11
Extreme vibration often occurs on TBM main system during the tunneling process. This paper established the mathematical model for TBM main system considering the impact load, time-varying internal incentive and the complex coupling relationship between each vibration degree of freedom. The dynamic model was modified by the multi-point vibration measured data. The calculation error of the system response of the main support frame’s main vibration direction was within 10 %. And it was found that the overturning vibration and axial vibration of the system were the main forms of vibration of the system. It was determined that the low-frequency vibration of 15-20 Hz was a coupled vibration of system’s first to fourth mode vibration mode. Based on the vibration characteristics of TBM main system, this paper designed a tuned mass vibration absorption structure (TMVAS) that can adapt to the multi degree of freedom (MDOF) coupling vibration of TBM main system during the actual tunneling process. To minimize system vibration, the optimal design parameters of the system was determined. The maximum amplitude of the axial and horizontal overturning vibration of the support frame was reduced by 26.7 % and 13 %, and the maximum amplitude of the cutterhead’s axial vibration was reduced by 23.2 %.
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