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- 저자 : Weimin Gan (검색결과 2 건)
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Weimin Wang,Feifei Wu,Ping Ma,Silin Gan,Xue Li,Li Chen,Ling Sun,Hui Sun,Zhongxing Jiang,Feng Guo 한국분자세포생물학회 2020 Molecules and cells Vol.43 No.8
The imbalance between the proliferation and apoptosis of B-cell precursors is an important contributor to the pathogenesis of B-cell precursor acute lymphoblastic leukemia (BCP-ALL), while its specific regulatory mechanism remains perplexing. This study aimed to expound the underlying mechanism of the proliferation and apoptosis of BCP-ALL cells from the perspective of non-coding RNA. In this study, long non-coding RNA colorectal neoplasia differentially expressed (LncRNA CRNDE) was upregulated in the bone marrow of BCP-ALL patients and BCP-ALL cell lines (NALM-6 and RS4;11). Functionally, LncRNA CRNDE knockdown restrained cell proliferation and boosted cell apoptosis in NALM-6 and RS4;11 cells. The subsequent investigation confirmed that LncRNA CRNDE bound to miR-345-5p and negatively regulated miR-345-5p expression. The overexpression of miR-345-5p suppressed cell proliferation and boosted cell apoptosis in NALM-6 and RS4;11 cells. Further experiments revealed that miR-345-5p downregulated cyclic AMP response element-binding protein (CREB) expression by targeting its mRNA directly. CREB overexpression reversed the effect of miR-345-5p mimic on cell proliferation and apoptosis in NALM-6 and RS4;11 cells. Finally, in vivo experiments showed that LncRNA CRNDE knockdown prolonged the survival of mice xenotransplanted with NALM-6 cells. In conclusion, LncRNA CRNDE upregulated CREB expression by suppressing miR-345-5p, thus promoting cell proliferation and reducing cell apoptosis in BCP-ALL.
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Fangjie Mo,Erdong Wu,Changsheng Zhang,Hong Wang,Zhengye Zhong,Jian Zhang,Bo Chen,Michael Hofmann,Weimin Gan,Guangai Sun 대한금속·재료학회 2018 METALS AND MATERIALS International Vol.24 No.5
The present work attempts to reveal the correlation between the microstructural defects and residual stress in the singlecrystal nickel-based superalloy, both of which play the signifi cant role on properties and performance. Neutron diff ractionwas employed to investigate the microstructural defects and residual stresses in a single crystal (SC) nickel-based superalloy,which was subjected to creeping under 220 MPa and 1000 °C for different times. The measured superlattice andfundamental lattice refl ections confi rm that the mismatch and tetragonal distortions with c / a > 1 exist in the SC superalloy. At the initially unstrained state, there exists the angular distortion between γ and γ’ phases with small triaxial compressivestresses, ensuring the structural stability of the superalloy. After creeping, the tetragonal distortion for the γ phase is largerthan that for the γ’ phase. With increasing the creeping time, the mismatch between γ and γ’ phases increases to the maximum,then decreases gradually and fi nally remains unchanged. The macroscopic residual stress shows a similar behaviorwith the mismatch, indicating the correlation between them. Based on the model of shear and dislocations, the evolution ofmicrostructural defects and residual stress are reasonably explained. The effect of shear is dominant at the primary creepstage, which greatly enlarges the mismatch and the residual stress. The dislocations weaken the effect of shear for the furthercreep stage, resulting in the decrease of the mismatch and relaxation of the residual stress. Those fi ndings add some helpfulunderstanding into the microstructure-performance relationship in the SC nickel-based superalloy, which might provide theinsight to materials design and applications.
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