Identification of Genes and MicroRNAs Involved in Ovarian Carcinogenesis

Wan, Shu-Mei,Lv, Fang,Guan, Ting Asian Pacific Journal of Cancer Prevention 2012 Asian Pacific journal of cancer prevention Vol.13 No.8

MicroRNAs (miRNAs) play roles in the clinic, both as diagnostic and therapeutic tools. The identification of relevant microRNAs is critically required for ovarian cancer because of the prevalence of late diagnosis and poor treatment options currently. To identify miRNAs involved in the development or progression of ovarian cancer, we analyzed gene expression profiles downloaded from Gene Expression Omnibus. Comparison of expression patterns between carcinomas and the corresponding normal ovarian tissues enabled us to identify 508 genes that were commonly up-regulated and 1331 genes that were down-regulated in the cancer specimens. Function annotation of these genes showed that most of the up-regulated genes were related to cell cycling, and most of the down-regulated genes were associated with the immune response. When these differentially expressed genes were mapped to MiRTarBase, we obtained a total of 18 key miRNAs which may play important regulatory roles in ovarian cancer. Investigation of these genes and microRNAs should help to disclose the molecular mechanisms of ovarian carcinogenesis and facilitate development of new approaches to therapeutic intervention.

Influence of Salts on Compressibility of Loess in Heifangtai Terrace, China

( Borui Lv ),( Ling Xu ),( Chongyang Gao ),( Dongdong Yan ),( Yili Wan ) 대한지질공학회 2019 대한지질공학회 학술발표회논문집 Vol.2019 No.2

Many researches had demonstrated that salts, including soluble and insoluble salts, played a considerable role on loess structure and mineral composition. It was found salts were leached out of the loess because of agricultural irrigation, in Heifangtai terrace in China, where a large number of landslides occurred. To study the effect of salts on compressibility of loess, a series of one-dimensional oedometer tests were performed. The loess washed by water or acetic acid solution, which was to avoid the interference of original salts, was powdered and reconstituted with distilled water, then the samples were immersed in NaCl solution or added a certain mass of lime and contacted with carbon dioxide to form calcium carbonate. Comparing the compression behavior, the results showed that the variation of compressibility of samples reconstituted by loess treated by distilled water or acid solution was indistinctive. The NaCl solution had a little effect on loess compressibility at high water content, while the NaCl solution would weaken loess compressibility at low water content, compared with samples treated by distilled water, and a threshold water content was gained. Besides, the compressibility of loess treated by adding lime was strongly improved. These findings can rich the study in microstructure of loess and are of importance to guide the geotechnical application.

Port four: Others : Preventing Mother-to-Child transmission of HIV impact and factors

( Xue Xia Lv ),( Chong Hua Wan ),( Liang Chen ) 한국환경보건학회(구-한국환경위생학회) 2004 Current Challenges and Advances in Environmental H Vol.- No.-

Experimental study of sodium fire and its characteristics under the coupling action of columnar liquid sodium flow and concrete

Huo, Yan,Zou, Gao-Wan,Dong, Hui,Lv, Jian-Fu,He, Jian Korean Nuclear Society 2021 Nuclear Engineering and Technology Vol.53 No.9

The complex coupling relationship between liquid sodium and concrete materials affects both the sodium fire characteristics and concrete properties through heat and chemical erosion. In this study, experiments on direct and indirect (separated by a steel plate) contact of the columnar sodium fire with the concrete surface were performed. It was found that the combustion efficiency of liquid sodium in direct contact with concrete was significantly enhanced and accompanied by intermittent explosions and splashing of small concrete fragments. The sodium fire on the surface of the concrete considerably increased the internal temperature, pore size, and distribution density of the concrete. In addition, the depth of influence on the loosening of the concrete structure was also greatly extended. The contact of liquid sodium with the concrete substantially affected its permeability resistance. The water absorption of the concrete surface was increased by more than 70% when liquid sodium directly impacted the bare concrete surface. However, the change in water absorption in the centre of the concrete was primarily affected by the duration of the external heat.

Carbon Nanotubes/MnO2 Composite Fabricated via Laser Welding and Electrodeposition as Flexible Electrode for Supercapacitors

Mingping He,Jianguang Li,Wanli Xu,Zhenqiang Dong,Yuechao Wu,Liang Lv 성균관대학교(자연과학캠퍼스) 성균나노과학기술원 2019 NANO Vol.14 No.6

Carbon nanotubes (CNTs) were welded on the surface of thermoplastic polypropylene (PP) substrate by laser irradiation and then manganese dioxide (MnO2) was deposited on the surface of CNTs by electrochemical method to prepare CNTs/MnO2 flexible electrodes (L-CM). The microstructure and morphology of CNTs/MnO2 composites were characterized by X-ray diffraction (XRD), X-ray photoelectron spectroscopy (XPS) and scanning electron microscopy (SEM). The results showed that CNTs were welded on the surface of the substrate, adhering to each other to form a porous network structure. In addition, there were distinct small protrusions on the surface of CNTs, indicating that MnO2 had been successfully deposited on the surface of CNTs. Cyclic voltammogram (CV), galvanostatic charge/discharge (GCD) and electrochemical impedance spectroscopy (EIS) techniques were employed to investigate the electrochemical performance of the composites. Compared with CNTs/MnO2 composite prepared via compaction (denoted as C-CM), L-CM composite prepared under the laser power of 0.75W (denoted as L-CM75) showed a larger capacitance of 214.6 F g-1 at the current density of 0.5 A g-1 and displayed excellent bendability, demonstrating capacitance retention of approximately 89.6% after 1000 bending cycles. The excellent performance of L-CM75 may be attributed to the fact that the CNTs welded on the substrate have formed an effective conductive network whose porous structure can facilitate easy access of electrolytes to the electrode, which results in enhancement of the electrochemical performance of L-CM75.

Two-stage Gradient-based Iterative Estimation Methods for Controlled Autoregressive Systems Using the Measurement Data

Feng Ding,Lei Lv,Jian Pan,Xiangkui Wan,Xue-Bo Jin 제어·로봇·시스템학회 2020 International Journal of Control, Automation, and Vol.18 No.4

This paper considers the parameter identification problems of controlled autoregressive systems using observation information. According to the hierarchical identification principle, we decompose the controlled autoregressive system into two subsystems by introducing two fictitious output variables. Then a two-stage gradientbased iterative algorithm is proposed by means of the iterative technique. In order to improve the performance of the tracking the time-varying parameters, we derive a two-stage multi-innovation gradient-based iterative algorithm based on the multi-innovation identification theory. Finally, an example is provided to illustrate the effectiveness of the proposed algorithms.

Association of CYP2E1 and NAT2 Polymorphisms with Lung Cancer Susceptibility among Mongolian and Han Populations in the Inner Mongolian Region

Zhang, Jing-Wen,Yu, Wan-Jia,Sheng, Xiao-Min,Chang, Fu-Hou,Bai, Tu-Ya,Lv, Xiao-Li,Wang, Guang,Liu, Su-Zhen Asian Pacific Journal of Cancer Prevention 2014 Asian Pacific journal of cancer prevention Vol.15 No.21

Purpose: To explore associations of CYP2E1 and NAT2 polymorphisms with lung cancer susceptibility among Mongolian and Han populations in the Inner Mongolian region. Materials and Methods: CYP2E1 and NAT2 polymorphisms were detected by PCR-RFLP in 930 lung cancer patients and 1000 controls. Results: (1) Disequilibrium of the distribution of NAT2 polymorphism was found in lung cancer patients among Han and Mongolian populations (p=0.031). (2) Lung cancer risk was higher in individuals with c1, D allele of CYP2E1 RsaI/PstI, DraI polymorphisms and slow acetylation of NAT2 (c1 compared with c2, OR=1.382, 95%CI: 1.178-1.587, p=0.003; D compared with C, OR=1.241, 95%CI: 1.053-1.419, P<0.001; slow acetylation compared with rapid acetylation, OR=1.359, 95%CI:1.042-1.768, p=0.056) (3) Compared with c2/c2 and rapid acetylation, c1/c1 together with slow acetylation synergetically increased risk of lung cancer 2.83 fold. (4) Smokers with CYP2E1 c1/c1, DD, and NAT2 slow acetylation have 2.365, 1.916, 1.841 fold lung cancer risk than others with c2/c2, CC and NAT2 rapid acetylation, respectively. (5) Han smokers with NAT2 slow acetylation have 1.974 fold lung cancer risk than others with rapid acetylation. Conclusions: Disequilibrium distribution of NAT2 polymorphism was found in lung cancer patients among Han and Mongolian populations. Besides, Han smokers with NAT2 slow acetylation may have higher lung cancer risk compared with rapid acetylation couterparts. CYP2E1 c1/c1, DD and NAT2 slow acetylation, especially combined with smoking, contributes to the development of lung cancer. CYP2E1 c1/c1 or DD genotype and NAT2 slow acetylation have strong synergistic action in increasing lung cancer risk.

Parametric study of SMA helical spring braces for the seismic resistance of a frame structure

Jincheng Ding,Bin Huang,Hongwang Lv,Hongxia Wan 국제구조공학회 2020 Smart Structures and Systems, An International Jou Vol.25 No.3

This paper studies the influence of parameters of a novel SMA helical spring energy dissipation brace on the seismic resistance of a frame structure. The force-displacement relationship of the SMA springs is established mathematically based on a multilinear constitutive model of the SMA material. Four SMA helical springs are fabricated, and the forcedisplacement relationship curves of the SMA springs are obtained via tension tests. A numerical dynamic model of a twofloor frame with spring energy dissipation braces is constructed and evaluated via vibration table tests. Then, two spring parameters, namely, the ratio of the helical spring diameter to the wire diameter and the pre-stretch length, are selected to investigate their influences on the seismic responses of the frame structure. The simulation results demonstrate that the optimal ratio of the helical spring diameter to the wire diameter can be found to minimize the absolute acceleration and the relative displacement of the frame structure. Meanwhile, if the pre-stretch length is assigned a suitable value, excellent vibration reduction performance can be realized. Compared with the frame structure without braces, the frames with spring braces exhibit highly satisfactory seismic resistance performance under various earthquake waves. However, it is necessary to select an SMA spring with optimal parameters for realizing optimal vibration reduction performance.

Study on the Correlation between Extracellular Matrix Protein-1 and the Growth, Metastasis and Angiogenesis of Laryngeal Carcinoma

Meng, Xin-Yu,Liu, Juan,Lv, Feng,Liu, Ming-Qiu,Wan, Jing-Ming Asian Pacific Journal of Cancer Prevention 2015 Asian Pacific journal of cancer prevention Vol.16 No.6

Objective: To investigate the correlation between extracellular matrix protein-1 (ECM1) and the growth, metastasis and angiogenesis of laryngeal carcinoma. Materials and Methods: Forty-five samples with laryngeal benign and malignant tumors confirmed by pathology in Laiwu City People's Hospital from March 2006 to March 2011 were collected, in which there were 29 cases with laryngeal carcinoma and 16 with benign tumors. The expression of ECM1 and factor VIII-related antigens in patients with laryngeal carcinoma and those with benign tumors was respectively detected using immunohistochemical method, and the correlation between ECM1 staining grade and microvessel density (MVD) was analyzed. Results: In laryngeal carcinoma tissue, ECM1 was mainly expressed in cytoplasm, less in cytomembrane or intercellular substance. With abundant expression in the tissue of laryngeal benign tumors (benign mesenchymoma and hemangioma), ECM1 was primarily expressed in the connective tissue, which was different from the expression in laryngeal carcinoma tissue. The proportion of positive ECM1 staining (++) in patients with laryngeal carcinoma was dramatically higher than those with benign tumors (p<0.05), and that of strongly-positive ECM1 staining (+++) slightly higher. The results of Spearman nonparametric correlation analysis revealed that ECM1 staining grade in laryngeal carcinoma tissue had a significantly-positive correlation with MVD (r=0.866, p=0.000). Conclusions: ECM1 expression in laryngeal carcinoma is closely associated with tumor cell growth, metastasis and angiogenesis, which can be considered as an effective predictor in the occurrence and postoperative recurrence of laryngeal carcinoma.

Corona generated Radio Interference of the 750 kV AC Bundle Conductors in Sandy and Dusty Weather Condition in the High Altitude Area

Liu, Yun-Peng,Zhu, Lei,Lv, Fang-Cheng,Wan, Bao-Quan,Pei, Chun-Ming The Korean Institute of Electrical Engineers 2014 Journal of Electrical Engineering & Technology Vol.9 No.5

Sandy and dusty weather condition often occurs in the high altitude areas of China, which may greatly influence the corona generated radio interference (RI) characteristics of the bundle conductors of 750 kV AC power transmission lines. Corona generated RI of the conductors of the 750 kV AC power transmission lines used in practice is measured by EMI receiver with a coupling circuit and a coupling capacitor connected between the high voltage side and the earth side in fine and sandy and dusty condition. The measuring frequency is 0.5 MHz, and the quasi-peak detection is used. RI excitation function is calculated based on the corona RI current measured by the EMI receiver. Corona generated RI characteristics were analyzed from sand concentration and sand particle size. The test result shows that the corona generated RI excitation function is influenced by the sandy and dusty condition. Corona discharge of the conductors is more serious in sandy and dusty condition with an ultraviolet (UV) detector. Corona generated RI excitation function increases with the increase of sand concentration and also increases with the increase of particle size.