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A Survey Among Wheelchair Users Who Participated in Banie Free 2010 Trade Show
Toru Furui,Haruka Onishi,Masahiro Kagatanj,Sayaka Sako,Kensuke Hiramoto,Rie Yonezawa,Takashi Handa,Minoru Tanaka 한국재활복지공학회 2010 한국재활복지공학회 학술대회논문집 Vol.2010 No.11
Objectives of this study is to explore factors impacting their pain and discomfort, and to advocate seating ergonomics in public. We set up a seating clinic booth and conducted survey among wheelchair users at Barrie Free 2010 Trade Show held at Intec Osaka from April 15th to April 17<SUP>th</SUP> 2010.Weanalyzedtheseated posture using software "Rysis", which designed based on ISO 16840-1. Results showed pelvis and trunk asymmetry, joystick controller side, and neck pain made impact on their seated posture. With this clinical consultation process of this work, users can satisfy their interest in objective findings of their seated posture, and experience the importance of ergonomic seating.
Calcitonin induces connective tissue growth factor through ERK1/2 signaling in renal tubular cells
Misa Nakamura,Takashi Ozaki,Aiko Ishii,Masayoshi Konishi,Yuji Tsubota,Toru Furui,Hayato Tsuda,Ichiro Mori,Kiichiro Ota,Kennichi Kakudo 생화학분자생물학회 2009 Experimental and molecular medicine Vol.41 No.5
Calcitonin (CT), a polypeptide hormone, plays important roles in a variety of physiological processes. CT has been used clinically to treat osteoporosis and humoral hypercalcemia of malignancy. In order to clarify the pharmacological effects of CT in the kidney, we identified potential downstream genes induced by CT in the renal cells. Using a cDNA subtraction hybridization method, we identified connective tissue growth factor (CTGF) as a CT-induced gene in the porcine renal cell line, LLC-PK1. Furthermore, we found that CT-mediated induction of the gene was not inhibited by cycloheximide, which suggests that CTGF gene was not induced by an increased synthesis of regulating proteins. Therefore, CTGF is an immediate early gene. We further demonstrated that the regulation of CTGF gene expression by CT involved the ERK1/2 pathway, because PD98059, a MEK1 inhibitor, partially inhibited the mRNA expression of CTGF induced by CT. CT-induced CTGF protein expression was also observed in vivo. Our present findings suggest that CT induces the transcription of CTGF through ERK1/2 phosphorylation. We also identified twelve other genes induced by CT that, like CTGF, were related to wound healing. These results suggest that CT may have an effect on renal differentiation and wound healing in the kidney. Calcitonin (CT), a polypeptide hormone, plays important roles in a variety of physiological processes. CT has been used clinically to treat osteoporosis and humoral hypercalcemia of malignancy. In order to clarify the pharmacological effects of CT in the kidney, we identified potential downstream genes induced by CT in the renal cells. Using a cDNA subtraction hybridization method, we identified connective tissue growth factor (CTGF) as a CT-induced gene in the porcine renal cell line, LLC-PK1. Furthermore, we found that CT-mediated induction of the gene was not inhibited by cycloheximide, which suggests that CTGF gene was not induced by an increased synthesis of regulating proteins. Therefore, CTGF is an immediate early gene. We further demonstrated that the regulation of CTGF gene expression by CT involved the ERK1/2 pathway, because PD98059, a MEK1 inhibitor, partially inhibited the mRNA expression of CTGF induced by CT. CT-induced CTGF protein expression was also observed in vivo. Our present findings suggest that CT induces the transcription of CTGF through ERK1/2 phosphorylation. We also identified twelve other genes induced by CT that, like CTGF, were related to wound healing. These results suggest that CT may have an effect on renal differentiation and wound healing in the kidney.