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Antimicrobial Aflatoxins from the Marine-Derived Fungus Aspergillus flavus 092008
Hui Wang,Wei-Ming Zhu,Zhenyu Lu,Hai-Jun Qu,Peipei Liu,Chengdu Miao,Tonghan Zhu,Jing Li,Kui Hong 대한약학회 2012 Archives of Pharmacal Research Vol.35 No.8
A new aflatoxin, aflatoxin B2b (1), together with six known compounds, were isolated from the marine-derived fungus Aspergillus flavus 092008 endogenous with the mangrove plant Hibiscus tiliaceus (Malvaceae). The structure of 1 was determined by the spectroscopic and chemical methods. Compound 1 exhibited a moderate antimicrobial activity against Escherichia coli, Bacillus subtilis and Enterobacter aerogenes, with MIC values of 22.5, 1.7 and 1.1 μM, respectively. Compound 1 also showed a weak cytotoxicity against A549, K562 and L-02 cell lines, with IC50 values of 8.1, 2.0 and 4.2 μM, respectively. The results showed that hydration and hydrogenation of Δ8-double bond significantly reduces the cytotoxicity of aflatoxins, while the esterification at C-8 increases the cytotoxicity.
Pyrazinone derivatives from the coral-derived Aspergillus ochraceus LCJ11-102 under high iodide salt
Xiaoping Peng,Yi Wang,Tonghan Zhu,Wei-Ming Zhu 대한약학회 2018 Archives of Pharmacal Research Vol.41 No.2
Five new pyrazin-2(1H)-one derivatives, ochramidesA–D (1–4) and ochralate A (5), as well as threeknown analogues (6–8) were isolated from the fermentationbroth of the marine coral-derived halotolerant Aspergillusochraceus LCJ11-102 in a nutrient-limited mediumcontaining 10% NaI. Their chemical structures weredetermined by analyzing NMR and X-ray diffraction data. Compounds 2, 5 and 6 showed antimicrobial activitiesagainst Enterobacter aerogenes with the MIC values of40.0, 18.9, and 20.1 lM, respectively.