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- 저자 : Tomonori Ito (검색결과 5 건)
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Ito, Atsushi,Kaneko, Tadashi,Miyamoto, Yuka,Ishii, Keiichiro,Fujita, Hitoshi,Hayashi, Tomonori,Sasaki, Masako Korean Society of Photoscience 2002 Journal of Photosciences Vol.9 No.2
A new concept of "photo" -antisense method has been evaluated, where the inhibition of gene expression by the conventional antisense method is enhanced by photochemical binding between antisense oligonucleotides conjugated with photo-reactive compound and target mRNA or DNA. Fluorescein labeled oligodeoxyribonucleotides (F-DNA) was delivered to cell nuclei in the encapsulated form in multilamellar lecithin liposomes with neutral charge. F-DNA was previously shown to photo-bind to the complementary stranded DNA, and the delivery system using neutral liposome to be effective in normal human keratinocytes. In the present study, we used human kidney cancer G401.2/6TG.1 cell line to be advantageous in reproducible experiments. p53 was adopted as a target gene since antisense sequence information has been accumulated. The nuclear localization ofF-DNA was identified by comparing the fluorescence ofF-DNA with that of Hoechst 33258 under fluorescence microscope. After 7hr incubation to accumulate p53 protein induced by UV -B, p53 protein was quantified by Western blot. After 2hrs from F-DNA application, about 30% of cell population incorporated F-DNA in their nuclei with some morphological change possibly due to liposomal toxicity. Irradiation of visible light longer than 400nm from solar simulator at this time enhanced the inhibitory action of antisense F-DNA. The present results suggest that photo-antisense method is promising to control gene expression in time and space dependent manner. Further improvement of F-DNA delivery to cancer cells in the stability and toxicity is in progress. progress.
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Role of Interfacial B Impurity in the Magnetocrystalline Anisotropy at MgO/Fe Interface
Koji Hotta,Kohji Nakamura,Toru Akiyama,Tomonori Ito 한국물리학회 2013 THE JOURNAL OF THE KOREAN PHYSICAL SOCIETY Vol.63 No.3
The structural stability and the magnetocrystalline anisotropy (MCA) at MgO/Fe(001) interfaceswith the incorporation of interfacial B atoms were investigated by using first-principles calculations. Total energy calculations predicted that the B atoms favored segregating to the interface. Thecalculated MCA energy for an ideal abrupt MgO/Fe interface (with no B atom) indicated that themagnetization strongly favored pointing along the perpendicular direction. However, when B atomswere incorporated at the MgO/Fe interfaces, the perpendicular MCA almost disappeared.
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Structural and Elastic Properties of the Magnetic Shape Memory Ni2MnGa1−xInx Alloy
Fumiya Kitanishi,Kohji Nakamura,Toru Akiyama,Tomonori Ito 한국물리학회 2013 THE JOURNAL OF THE KOREAN PHYSICAL SOCIETY Vol.63 No.3
The structural and the elastic properties of the magnetic shape memory Ni2MnGa1−xInx (x 0.25) alloy were investigated from first principles calculations within the generalized gradient approximationby using the full-potential linearized augmented plane-wave method and the Connolly-Williams cluster expansion method. The calculated lattice constant and bulk modulus have analmost linear dependence on the In composition x, where the former increases and the latter decreaseswhen x increases. In contrast, the calculated shear modulus, C0 = (C11 − C12)/2, of thedisordered state, which shows a nonlinear dependence on x, indicates that a deviation from thestoichiometric composition Ni2MnGa (x = 0) enhances the elastic tetragonal anisotropy.
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Magnetism and Multiplets in Fe-phthalocyanine Molecules
Yukie Kitaoka,Kohji Nakamura,Toru Akiyama,Tomonori Ito,M. Weinert,A. J. Freeman 한국물리학회 2013 THE JOURNAL OF THE KOREAN PHYSICAL SOCIETY Vol.63 No.3
Magnetism and multiplets for Fe-phthalocyanine molecules were investigated based on the constraintdensity functional theory (DFT) by imposing a density matrix constraint on the d-orbitaloccupation numbers. We demonstrate that for a single FePc molecule, there are three stationarystates of multiplets, 3Eg, 3A2g, and 3B2g, and that the magnetic anisotropy (MA) strongly dependson the multiplet structures. The ground state of the 3A2g obtained from the constraint DFT totalenergy calculations has planar MA, with the spin moments pointing along the molecule’s planardirection. The columnar stacking structure for α-FePc, with the ground state of the 3Eg, showsplanar MA.
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Existence of a Neuropathic Pain Component in Patients with Osteoarthritis of the Knee
Seiji Ohtori,Sumihisa Orita,Masaomi Yamashita,Tetsuhiro Ishikawa,Toshinori Ito,Tomonori Shigemura,Hideki Nishiyama,Shin Konno,Hideyuki Ohta,Masashi Takaso,Gen Inoue,Yawara Eguchi,Nobuyasu Ochiai,Shunj 연세대학교의과대학 2012 Yonsei medical journal Vol.53 No.4
Purpose: Pain from osteoarthritis (OA) is generally classified as nociceptive (inflammatory). Animal models of knee OA have shown that sensory nerve fibers innervating the knee are significantly damaged with destruction of subchondral bone junction, and induce neuropathic pain (NP). Our objective was to examine NP in the knees of OA patients using painDETECT (an NP questionnaire) and to evaluate the relationship between NP, pain intensity, and stage of OA. Materials and Methods:Ninety-two knee OA patients were evaluated in this study. Pain scores using Visual Analogue Scales (VAS), Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC), painDETECT, duration of symptoms, severity of OA using the Kellgren-Lawrence (KL) system, and amount of joint fluid were evaluated and compared using a Spearman’s correlation coefficient by rank test. Results: Our study identified at least 5.4% of our knee OA patients as likely to have NP and 15.2% as possibly having NP. The painDETECT score was significantly correlated with the VAS and WOMAC pain severity. Compared with the painDETECT score, there was a tendency for positive correlation with the KL grade, and tendency for negative correlation with the existence and amount of joint fluid, but these correlations were not significant. Conclusion: PainDETECT scores classified 5.4% of pain from knee OA as NP. NP tended to be seen in patients with less joint fluid and increased KL grade, both of which corresponded to late stages of OA. It is important to consider the existence of NP in the treatment of knee OA pain.
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