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Metabolic engineering of Escherichia coli for L-homoserine production from glucose
( Vo Minh Toan ),( Kieu Thi Quynh Hoa ),( Sunghoon Park ) 한국공업화학회 2019 한국공업화학회 연구논문 초록집 Vol.2019 No.0
Two-amino-4-hydroxybutanoic acid (i.e., homoserine), is not only a microbial metabolite but also a valuable building block for synthesis of various chemical compounds. Several by-product pathways were disrupted and several enzymes related to homoserine production were up-regulated in Escherichia coli. By modifying the glucose uptake system, cell growth and glucose consumption could be partially restored in the mutant strain. Furthermore, by up-regulation of phosphoenol-pyruvate carboxylase, carbon flux was more diverted to homoserine and acetate production was more reduced. One new mutant strain having mutations in >12 genes could produce 2 g/L homoserine in flask culture.