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RISS 인기검색어
- 검색키워드
- 저자 : Timar, Bracha (검색결과 4 건)
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Madar, Zecharia,Stark, Aliza H.,Ilan, Erez,Timar, Bracha,Borenshtein, Diana The Korean Society of Food Science and Nutrition 2002 Preventive Nutrition and Food Science Vol.7 No.2
Alpha-lipoic acid is a known hypoglycemic agent that may be useful in the treatment of diabetes. The objective of this study was to investigate the fate of glucose in isolated muscles incubated with lipoic acid by determining its direct effects on specific metabolic and signaling pathways. Soleus muscles from healthy rats were incubated with lipoic acid in the absence or presence of insulin. Glucose transport, glycogen synthesis, glucose oxidation and lipid synthesis were determined and affects on major pathways associated with insulin signaling were evaluated. Glucose transport was not significantly altered by the addition of lipoic acid to the incubation medium. However, lipoic acid decreased glycogen synthesis in comparison to controls. Glucose oxidation was moderately increased while de-novo lipid synthesis from glucose was inhibited. Wortmannin repressed insulin stimulation of glucose incorporation into glycogen, an effect that was augmented by the combined treatment of wortmannin and lipoic acid. Basal and insulin-stimulated serine phosphorylation of Akt was not changed by the addition of lipoic acid to the incubation medium. These data show that in this in vitro model, lipoic acid did not significantly affect glucose uptake but dramatically modified pathways of glucose metabolism within muscle tissue.
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Aliza H. Stark,Erez Ilan,Bracha Timar,Diana Borenshtein,Zecharia Madar 한국식품영양과학회 2002 Preventive Nutrition and Food Science Vol.7 No.2
Alpha-lipoic acid is a known hypoglycemic agent that may be useful in the treatment of diabetes. The objective of this study was to investigate the fate of glucose in isolated muscles incubated with lipoic acid by determining its direct effects on specific metabolic, signaling pathways. Soleus muscles from healthy rats were incubated with lipoic acid in the absence or presence of insulin. Glucose transport, glycogen synthesis, glucose oxidation, lipid synthesis were determined, affects on major pathways associated with insulin signaling were evaluated. Glucose transport was not significantly altered by the addition of lipoic acid to the incubation medium. However, lipoic acid decreased glycogen synthesis in comparison to controls. Glucose oxidation was moderately increased while de-novo lipid synthesis from glucose was inhibited. Wortmannin repressed insulin stimulation of glucose incorporation into glycogen, an effect that was augmented by the combined treatment of wortmannin, lipoic acid. Basal, insulin-stimulated serine phosphorylation of Akt was not changed by the addition of lipoic acid to the incubation medium. These data show that in this in vitro model, lipoic acid did not significantly affect glucose uptake but dramatically modified pathways of glucose metabolism within muscle tissue.
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Neural-based prediction of structural failure of multistoried RC buildings
Sirshendu Hore,Sankhadeep Chatterjee,Sarbartha Sarkar,Nilanjan Dey,Amira S. Ashour,Dana Bălas-Timar,Valentina E. Balas 국제구조공학회 2016 Structural Engineering and Mechanics, An Int'l Jou Vol.58 No.3
Various vague and unstructured problems encountered the civil engineering/ designers that persuaded by their experiences. One of these problems is the structural failure of the reinforced concrete (RC) building determination. Typically, using the traditional Limit state method is time consuming and complex in designing structures that are optimized in terms of one/many parameters. Recent research has revealed the Artificial Neural Networks potentiality in solving various real life problems. Thus, the current work employed the Multilayer Perceptron Feed-Forward Network (MLP-FFN) classifier to tackle the problem of predicting structural failure of multistoried reinforced concrete buildings via detecting the failure possibility of the multistoried RC building structure in the future. In order to evaluate the proposed method performance, a database of 257 multistoried buildings RC structures has been constructed by professional engineers, from which 150 RC structures were used. From the structural design, fifteen features have been extracted, where nine features of them have been selected to perform the classification process. Various performance measures have been calculated to evaluate the proposed model. The experimental results established satisfactory performance of the proposed model.
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