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Video-assisted Thoracic Surgery Versus Thoracotomy for Non-small-cell Lung Cancer
Pan, Tie-Wen,Wu, Bin,Xu, Zhi-Fei,Zhao, Xue-Wei,Zhong, Lei Asian Pacific Journal of Cancer Prevention 2012 Asian Pacific journal of cancer prevention Vol.13 No.2
Video-assisted thoracic surgery (VATS) has been recommended as more optimal surgical technique than traditional thoracotomy for lobectomy in lung cancer, but it is not well defined. Here, we compared VATS and traditional thoracotomy based on clinical data. From November 2008 to November 2010, 180 patients underwent lobectomy for non-small-cell lung cancer (NSCL) identified by computerized tomography. Of them, 83 cases were performed with VATS and 97 by thoracotomy. Clinical parameters, consisting of blood loss, operating time, number of lymph node dissection, days of pleural cavity drainage, and length of stay were recorded and evaluated with t test. No significant difference was observed between the VATS and thoracotomy groups in the average intraoperative blood loss, number of lymph node dissections, and days of pleural cavity drainage. While the average operating time in the VATS group was significantly longer than that in thoracotomy group, recurrence was only present in one case, as opposed to 7 cases in the thoracotomy group In conclusion, similar therapeutic effects were demonstrated in VATS and thoracotomy for NSCL. However, VATS lobectomy was associated with fewer complications, recurrence and shorter length of stay.
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Zhang, Tie-Feng,Cheng, Ke-Wen,Shi, Wei-Yin,Zhang, Jin-Tao,Liu, Ke-Di,Xu, Shu-Guang,Chen, Ji-Quan Asian Pacific Journal of Cancer Prevention 2012 Asian Pacific journal of cancer prevention Vol.13 No.12
Background: Small-cell lung cancer (also known as SCLC) is an aggressive form and untreated patients generally die within about 3 months. To obtain further insight into mechanism underlying malignancy with this cancer, an miRNA synergistic regulatory network was constructed and analyzed in the present study. Method: A miRNA microarray dataset was downloaded from the NCBI GEO database (GSE27435). A total of 546 miRNAs were identified to be expressed in SCLC cells. Then a miRNA synergistic network was constructed, and the included miRNAs mapped to the network. Topology analysis was also performed to analyze the properties of the synergistic network. Consequently, we could identified constitutive modules. Further, common target genes of each module were identified with CFinder. Finally, enrichment analysis was performed for target genes. Results: In this study, a miRNA synergistic network with 464 miRNAs and 2981 edges was constructed. According to the topology analysis, the topological properties between the networks constructed by LC related miRNAs and LC unrelated miRNAs were significantly different. Moreover, a module cilque0 could be identified in our network using CFinder. The module included three miRNAs (hsa-let-7c, hsa-let-7b and hsa-let-7d). In addition, several genes were found which were predicted to be common targets of cilque0. The enrichment analysis demonstrated that these target genes were enriched in MAPK signaling pathways. Conclusions: Although limitations exist in the current data, the results uncovered here are important for understanding the key roles of miRNAs in SCLC. However, further validation is required since our results were based on microarray data derived from a small sample size.
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Xin-cai Xu,Wen-bin Zhang,Chun-xing Li,Hua Gao,Qi Pei,Bo-wei Cao,Tie-han He 연세대학교의과대학 2019 Yonsei medical journal Vol.60 No.1
Purpose: Helicobacter pylori (HP)-infected gastric cancer (GC) is known to be a fatal malignant tumor, but the molecular mechanismsunderlying its proliferation, invasion, and migration remain far from being completely understood. Our aim in this studywas to explore miR-1915 expression and its molecular mechanisms in regulating proliferation, invasion, and migration of HP-infectedGC cells. Materials and Methods: Quantitative real-time PCR and western blot analysis were performed to determine miR-1915 and receptorfor advanced glycation end product (RAGE) expression in HP-infected GC tissues and gastritis tissues, as well as humangastric mucosal cell line GES-1 and human GC cell lines SGC-7901 and MKN45. CCK8 assay and transwell assay were performedto detect the proliferation, invasion, and migration capabilities. MiR-1915 mimics and miR-1915 inhibitor were transfected intoGC cells to determine the target relationship between miR-1915 and RAGE. Results: MiR-1915 was under-expressed, while RAGE was over-expressed in HP-infected GC tissues and GC cells. Over-expressedmiR-1915 could attenuate cellular proliferation, invasion, and migration capacities. RAGE was confirmed to be the target gene ofmiR-1915 by bioinformatics analysis and luciferase reporter assay. Moreover, HP-infected GC cellular proliferation, invasion, andmigration were inhibited after treatment with pcDNA-RAGE. Conclusion: MiR-1915 exerted tumor-suppressive effects on cellular proliferation, invasion, and migration of HP-infected GCcells via targeting RAGE, which provided an innovative target candidate for treatment of HP-infected GC.
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Fu‑Hao Gao,Bin‑Jiang Lv,Tie‑Wei Xu,Ning Cui,Feng Guo 대한금속·재료학회 2023 METALS AND MATERIALS International Vol.29 No.11
The effects of low Sn (1.0 wt%) and Mn (0.5 wt%) content on the microstructures and mechanical properties of as-extrudedMg–2Al–1Zn (AZ21) alloys were systematically investigated. The combined addition of Sn and Mn significantly refinedthe grains of the AZ21 alloy, reducing the average grain size from 25.77 to 2.17 μm. The volume fraction of the dynamicallyrecrystallized (DRXed) grains decreased from 78.49 to 43.81% with Sn (1.0 wt%) and Mn (0.5 wt%) addition. The Al8Mn5,Al11Mn4,and Al9Mn4phases were formed in Mg–2Al–1Zn–1Sn–0.5Mn (AZTM2110) alloy, and the Mg17Al12phase disappeared. The orientation relationship between Al9Mn4and Al11Mn4was (002)Al11Mn4//(̄ 302)Al9Mn4, [ ̄ 100]Al11Mn4//[223]Al9Mn4,and the orientation relationship between Al8Mn5and α-Mg was ( ̄ 252)Al8Mn5//(̄ 12̄ 13)α−Mg. The Al9Mn4and Al11Mn4phasesgrew in the same direction. The intensity of basal fiber texture of AZTM2110 alloy decreased by 21.7%. The ultimatetensile strength, yield strength, and elongation of the AZ21 alloy increased by 29.03%, 65.05%, and 61.02%, respectively. Grain-refinement strengthening was the main mechanism underlying the improvement in AZTM2110 alloy strength. Grainrefinement and the weakened basal fiber texture improved the plasticity of the AZTM2110 alloy.
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