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Lee, Hang-Jae,Lee, Yuong-Nam,Adams, Thomas L.,Currie, Philip J.,Kobayashi, Yoshitsugu,Jacobs, Louis L.,Koppelhus, Eva B. Elsevier 2018 Palaeogeography, palaeoclimatology, palaeoecology Vol.494 No.-
<P><B>Abstract</B></P> <P>A theropod tracksite was discovered in the Nemegt Formation (Maastrichtian) at Bügiin Tsav, Mongolia by the Korea-Mongolia International Dinosaur Project in 2009. A total of 67 tracks (14 trackways [one didactylous, 13 tridactylous] and 12 isolated tracks) belonging to four ichnomorphotypes were mapped on a single horizon. This indicates at least four different theropod trackmakers lived in the same area at the same time. This tracksite consists of laminated gray mudstone-yellowish brown siltstone couplets interbedded with eolian yellowish brown sandstone deposited on a distal floodplain. Abundant footprints with V-shaped profiles (cross-section) within in the vertical section indicate that dinosaurs repeatedly walked across in this area. Before the discovery of the tracks, the site was illegally excavated by fossil poachers, a widespread problem in the Gobi Desert. During excavation of the track horizon, a clenched, inclined <I>Gallimimus</I> foot skeleton was found in the mudstone, extended down 20cm below the track-bearing sandstone layer. The occurrence of tracks closely associated with body fossils is unusual and taphonomically intriguing. It is possible that the foot skeleton represents an animal that died in its tracks. However, the depth of the foot in mud is probably too shallow for the animal to have been mired. Sedimentological and taphonomic evidence also suggests that the pes of <I>Gallimimus</I> may have passed straight through the track-bearing sandstone layer. The inclined right pes indicates that the body lay on its left side on the substrate. During decomposition in the mud, all digits were flexed but the distal phalanges were stuck and anchored in the stiff lower mud. Consequently, as more proximal phalanges were able to accommodate flexing, they were pulled away and dislocated from the anchored distal phalanges. Subsequent trampling by dinosaurs in the track-bearing sandstone would have further distorted the underlying foot.</P> <P><B>Highlights</B></P> <P> <UL> <LI> The first report of theropod trackways from the Nemegt Formation in Bügiin Tsav, Mongolia </LI> <LI> Taphonomic interpretation of a <I>Gallimimus</I> foot skeleton associated with theropod tracks </LI> <LI> An interpretation of disarticulation and distortion of the foot skeleton is proposed. </LI> </UL> </P>
Notch Pathway Targets Proangiogenic Regulator Sox17 to Restrict Angiogenesis
Lee, Seung-Hun,Lee, Sungsu,Yang, Hanseul,Song, Sukhyun,Kim, Kangsan,Saunders, Thomas L.,Yoon, Jeong K.,Koh, Gou Young,Kim, Injune American Heart Association, Inc. 2014 Circulation research Vol.115 No.2
<P><B><U>Rationale</U>:</B></P><P>The Notch pathway stabilizes sprouting angiogenesis by favoring stalk cells over tip cells at the vascular front. Because tip and stalk cells have different properties in morphology and function, their transcriptional regulation remains to be distinguished. Transcription factor Sox17 is specifically expressed in endothelial cells, but its expression and role at the vascular front remain largely unknown.</P><P><B><U>Objective</U>:</B></P><P>To specify the role of Sox17 and its relationship with the Notch pathway in sprouting angiogenesis.</P><P><B><U>Methods and Results</U>:</B></P><P>Endothelial-specific <I>Sox17</I> deletion reduces sprouting angiogenesis in mouse embryonic and postnatal vascular development, whereas <I>Sox17</I> overexpression increases it. Sox17 promotes endothelial migration by destabilizing endothelial junctions and rearranging cytoskeletal structure and upregulates expression of several genes preferentially expressed in tip cells. Interestingly, Sox17 expression is suppressed in stalk cells in which Notch signaling is relatively high. Notch activation by overexpressing Notch intracellular domain reduces Sox17 expression both in primary endothelial cells and in retinal angiogenesis, whereas Notch inhibition by delta-like ligand 4 (Dll4) blockade increases it. The Notch pathway regulates Sox17 expression mainly at the post-transcriptional level. Furthermore, endothelial <I>Sox17</I> ablation rescues vascular network from excessive tip cell formation and hyperbranching under Notch inhibition in developmental and tumor angiogenesis.</P><P><B><U>Conclusions</U>:</B></P><P>Our findings demonstrate that the Notch pathway restricts sprouting angiogenesis by reducing the expression of proangiogenic regulator Sox17.</P>
Lee, Byeongyong,Lee, Chongmin,Liu, Tianyuan,Eom, Kwangsup,Chen, Zhongming,Noda, Suguru,Fuller, Thomas F.,Jang, Hee Dong,Lee, Seung Woo Royal Society of Chemistry 2016 Nanoscale Vol.8 No.24
<P>Crumpled graphene is known to have a strong aggregation-resistive property due to its unique 3D morphology, providing a promising solution to prevent the restacking issue of graphene based electrode materials. Here, we demonstrate the utilization of redox-active oxygen functional groups on the partially reduced crumpled graphene oxide (r-CGO) for electrochemical energy storage applications. To effectively utilize the surface redox reactions of the functional groups, hierarchical networks of electrodes including r-CGO and functionalized few-walled carbon nanotubes (f-FWNTs) are assembled via a vacuum-filtration process, resulting in a 3D porous structure. These composite electrodes are employed as positive electrodes in Li-cells, delivering high gravimetric capacities of up to similar to 170 mA h g(-1) with significantly enhanced rate-capability compared to the electrodes consisting of conventional 2D reduced graphene oxide and f-FWNTs. These results highlight the importance of microstructure design coupled with oxygen chemistry control, to maximize the surface redox reactions on functionalized graphene based electrodes.</P>
Modern computer simulation for the design of concrete catenary shell structures
Lee, Joo Hong,Lee, Hyerin,Kang, Thomas H.K. TECHNO-PRESS 2018 COMPUTERS AND CONCRETE Vol.21 No.6
The purpose of this study was to model and design a concrete catenary shell using a modern computer program without performing experiments. The modeling idea stems from the study by Pendergrast, but he listed supplementary items that should be improved in his paper. This study aims to resolve those issues and overcome the drawbacks of the study by Pendergrast. The process of experiment for the design of a catenary shell was reproduced by Grasshopper script. In order to ensure credibility, two models designed from the Grasshopper script were analyzed using a finite element program, SAP2000; one is a square-based catenary shell and the other is a special catenary shell called as the Naturtheater <TEX>$Gr{\ddot{o}}tzingen$</TEX> shell, which was completed in 1977. First, the developed modeling approach was proved to be reasonable from the analysis of the square-based shell. The reliability was further confirmed by a comparison between the current and previous analysis results for the Naturtheater <TEX>$Gr{\ddot{o}}tzingen$</TEX> shell.
Lee, Sunho,Kim, Changhoon,Ann, Jihyae,Thorat, Shivaji A.,Kim, Eunhye,Park, Jongmi,Choi, Sun,Blumberg, Peter M.,Frank-Foltyn, Robert,Bahrenberg, Gregor,Stockhausen, Hannelore,Christoph, Thomas,Lee, Jee Pergamon Press 2017 Bioorganic & medicinal chemistry letters Vol.27 No.18
<P><B>Abstract</B></P> <P>A series of 1-substituted 3-(<I>t</I>-butyl/trifluoromethyl)pyrazole C-region analogues of 2-(3-fluoro-4-methylsulfonamidophenyl)propanamides were investigated for <I>h</I>TRPV1 antagonism. The structure activity relationship indicated that the 3-chlorophenyl group at the 1-position of pyrazole was the optimized hydrophobic group for antagonistic potency and the activity was stereospecific to the <I>S</I>-configuration, providing exceptionally potent antagonists <B>13<I>S</I> </B> and <B>16<I>S</I> </B> with <I>K<SUB>i(CAP)</SUB> </I> =0.1nM. Particularly significant, <B>13<I>S</I> </B> exhibited antagonism selective for capsaicin and NADA and not for low pH or elevated temperature. Both compounds also proved to be very potent antagonists for <I>r</I>TRPV1, blocking <I>in vivo</I> the hypothermic action of capsaicin, consistent with their <I>in vitro</I> mechanism. The docking study of compounds <B>13<I>S</I> </B> and <B>16<I>S</I> </B> in our <I>h</I>TRPV1 homology model indicated that the binding modes differed somewhat, with that of <B>13<I>S</I> </B> more closely resembling that of <B>GRT12360</B>.</P> <P><B>Graphical abstract</B></P> <P>[DISPLAY OMISSION]</P>
Apolipoprotein B binds to enolase-1 and aggravates inflammation in rheumatoid arthritis
Lee, Joo Youn,Kang, Min Jueng,Choi, Ji Yong,Park, Ji Soo,Park, Jin Kyun,Lee, Eun Young,Lee, Eun Bong,Pap, Thomas,Yi, Eugene C,Song, Yeong Wook H. K. Lewis 2018 Annals of the rheumatic diseases Vol. No.
<P>Conclusions A key component of atherogenic lipids, apoB, aggravated arthritis by potentiating the inflammatory response via its interaction with ENO1 expressed on the surface of immune cells. This suggests a novel mechanism by which lipid metabolism regulates chronic inflammation in RA.</P>
Lee, Ji-Woong,Mayer-Gall, Thomas,Opwis, Klaus,Song, Choong Eui,Gutmann, Jochen Stefan,List, Benjamin American Association for the Advancement of Scienc 2013 Science Vol.341 No.6151
<P><B>Catalytic Parachute</B></P><P>Small organic molecules have emerged as catalysts as versatile as transition metal complexes. However, industrial application of such organocatalysts has been hampered by technical challenges. Now <B>Lee <I>et al.</I></B> (p. 1225) have succeeded in tethering a diverse set of high-performance organocatalysts to nylon fabric through ultraviolet photochemistry, making them easy to isolate and reuse.</P>
Thomas, Karen C,Ethirajan, Manivannan,Shahrokh, Kiumars,Sun, Hao,Lee, Jeewoo,Cheatham, Thomas E,Yost, Garold S,Reilly, Christopher A Williams Wilkins 2011 The Journal of pharmacology and experimental thera Vol.337 No.2
<P>Activation of intracellular transient receptor potential vanilloid-1 (TRPV1) in human lung cells causes endoplasmic reticulum (ER) stress, increased expression of proapoptotic GADD153 (growth arrest- and DNA damage-inducible transcript 3), and cytotoxicity. However, in cells with low TRPV1 expression, cell death is not inhibited by TRPV1 antagonists, despite preventing GADD153 induction. In this study, chemical variants of the capsaicin analog nonivamide were synthesized and used to probe the relationship between TRPV1 receptor binding, ER calcium release, GADD153 expression, and cell death in TRPV1-overexpressing BEAS-2B, normal BEAS-2B, and primary normal human bronchial epithelial lung cells. Modification of the 3-methoxy-4-hydroxybenzylamide vanilloid ring pharmacophore of nonivamide reduced the potency of the analogs and rendered several analogs mildly inhibitory. Correlation analysis of analog-induced calcium flux, GADD153 induction, and cytotoxicity revealed a direct relationship for all three endpoints in all three lung cell types for nonivamide and N-(3,4-dihydroxybenzyl)nonanamide. However, the N-(3,4-dihydroxybenzyl)nonanamide analog also produced cytotoxicity through redox cycling/reactive oxygen species formation, shown by inhibition of cell death by N-acetylcysteine. Molecular modeling of binding interactions between the analogs and TRPV1 agreed with data for reduced potency of the analogs, and only nonivamide was predicted to form a 'productive' ligand-receptor complex. This study provides vital information on the molecular interactions of capsaicinoids with TRPV1 and substantiates TRPV1-mediated ER stress as a conserved mechanism of lung cell death by prototypical TRPV1 agonists.</P>