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- 저자 : Thomas Cohen (검색결과 4 건)
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Lymphopenia following pancreaticoduodenectomy is associated with pancreatic fistula formation
Joshua T. Cohen,Kevin P. Charpentier,Thomas J. Miner,William G. Cioffi,Rachel E. Beard 한국간담췌외과학회 2021 Annals of hepato-biliary-pancreatic surgery Vol.25 No.2
Backgrounds/Aims: Post-operative pancreatic fistulas (POPF) are a major source of morbidity following pancreaticoduodenectomy (PD). This study aims to investigate if persistent lymphopenia, a known marker of sepsis, can act as an additional marker of POPF with clinical implications that could help direct drain management. Methods: A retrospective chart review of all patients who underwent PD in a single hospital network from 2008 to 2018. Persistent lymphopenia was defined as lymphopenia beyond post-operative day #3. Results: Of the 201 patients who underwent PD during the study period 161 patients had relevant laboratory data, 81 of whom had persistent lymphopenia. 17 patients with persistent lymphopenia went on to develop a POPF, compared to 7 patients without. Persistent lymphopenia had a negative predictive value of 91.3%. Multivariate analysis revealed only persistent lymphopenia as being independently associated with POPF (HR 2.57, 95% CI 1.07-6.643, p=0.039). Patients with persistent lymphopenia were more likely to have a complication requiring intervention (56.8% vs 35.0%, p<0.001). Conclusions: Persistent lymphopenia is a readily available early marker of POPF that holds the potential to identify clinically relevant POPF in patients where no surgical drain is present, and to act as an adjunct of drain amylase helping to guide drain management.
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Solution Structure of a Prion Protein: Implications for Infectivity
He Liu,Shauna Farr-Jones,Nikolai Ulyanov,Manuel Llinas,Susan Marqusee,Fred E. Cohen,Stanley B. Prusiner,Thomas L. James 한국자기공명학회 1998 Journal of the Korean Magnetic Resonance Society Vol.2 No.2
Prions cause neurodegenerative diseases in animals and humans. The scrapie prion protein (PrPSc) is the major – possibly only – component of the infectious prion and is generated from the cellular isoform (PrPC) by a conformational change. Limited proteolysis of PrPSc produces a polypeptide comprised primarily of residues 90 to 231, which retains infectivity. The three-dimensional structure of rPrP(90-231), a recombinant protein resembling PrPC with the Syrian hamster (SHa) sequence, was solved using multidimensional NMR. Low-resolution structures of rPrP(90-231), synthetic peptides up to 56 residues, a longer (29-231, full-length) protein with SHa sequence, and a shorter (121-231) protein with the mouse sequence have been previously reported. We report here further structure refinement of rPrP(90-231) and dynamic features of the protein. Consideration of these features in the context of published data suggests regions of conformational heterogeneity, structural elements involved in the PrPC PrPSc transformation, and possible structural features related to a species barrier to transmission of prion diseases 영어논문
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Wireless Communication at 310 GHz using GaAs High-Electron-Mobility Transistors for Detection
Blin, Stephane,Tohme, Lucie,Coquillat, Dominique,Horiguchi, Shogo,Minamikata, Yusuke,Hisatake, Shintaro,Nouvel, Philippe,Cohen, Thomas,Penarier, Annick,Cano, Fabrice,Varani, Luca,Knap, Wojciech,Nagats The Korea Institute of Information and Commucation 2013 Journal of communications and networks Vol.15 No.6
We report on the first error-free terahertz (THz) wireless communication at 0.310 THz for data rates up to 8.2 Gbps using a 18-GHz-bandwidth GaAs/AlGaAs field-effect transistor as a detector. This result demonstrates that low-cost commercially-available plasma-wave transistors whose cut-off frequency is far below THz frequencies can be employed in THz communication. Wireless communication over 50 cm is presented at 1.4 Gbps using a uni-travelling-carrier photodiode as a source. Transistor integration is detailed, as it is essential to avoid any deleterious signals that would prevent successful communication. We observed an improvement of the bit error rate with increasing input THz power, followed by a degradation at high input power. Such a degradation appears at lower powers if the photodiode bias is smaller. Higher-data-rate communication is demonstrated using a frequency-multiplied source thanks to higher output power. Bit-error-rate measurements at data rates up to 10 Gbps are performed for different input THz powers. As expected, bit error rates degrade as data rate increases. However, degraded communication is observed at some specific data rates. This effect is probably due to deleterious cavity effects and/or impedance mismatches. Using such a system, realtime uncompressed high-definition video signal is successfully and robustly transmitted.
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Wireless Communication at 310 GHz Using GaAs High-Electron-Mobility Transistors for Detection
Stéphane Blin,Lucie Tohme,Dominique Coquillat,Shogo Horiguchi,Yusuke Minamikata,Shintaro Hisatake,Philippe Nouvel,Thomas Cohen,Annick Pénarier,Fabrice Cano,Luca Varani,Wojciech Knap,Tadao Nagatsuma 한국통신학회 2013 Journal of communications and networks Vol.15 No.6
We report on the first error-free terahertz (THz) wirelesscommunication at 0.310 THz for data rates up to 8.2 Gbps using a18-GHz-bandwidth GaAs/AlGaAs field-effect transistor as a detector. This result demonstrates that low-cost commercially-availableplasma-wave transistors whose cut-off frequency is far below THzfrequencies can be employed in THz communication. Wirelesscommunication over 50 cm is presented at 1.4 Gbps using a unitravelling-carrier photodiode as a source. Transistor integration isdetailed, as it is essential to avoid any deleterious signals that wouldprevent successful communication. We observed an improvementof the bit error rate with increasing input THz power, followed bya degradation at high input power. Such a degradation appearsat lower powers if the photodiode bias is smaller. Higher-dataratecommunication is demonstrated using a frequency-multipliedsource thanks to higher output power. Bit-error-ratemeasurementsat data rates up to 10 Gbps are performed for different inputTHz powers. As expected, bit error rates degrade as data rate increases. However, degraded communication is observed at somespecific data rates. This effect is probably due to deleterious cavityeffects and/or impedance mismatches. Using such a system, realtimeuncompressed high-definition video signal is successfully androbustly transmitted.
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