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- 저자 : Thi Minh Nhan TRAN (검색결과 4 건)
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Oral cavity: An open horizon for nanopharmaceuticals
Nguyen Oanh Oanh Thi,Tran Khue Dan,Ha Nhan Thi,Doan Sang Minh,Dinh Thi Thanh Hai,Tran Tuan Hiep 한국약제학회 2021 Journal of Pharmaceutical Investigation Vol.51 No.4
Background Oral administration is the primary route employed for drug delivery. In addition to the gastrointestinal tract, the oral cavity has been drawing considerable attention owing to its physiological properties and advances in drug carrier development. Notably, nanotechnology has made immense contributions to enhancing drug bioavailability, stability, and efficacy, both in research and clinical settings. Area covered The present review comprises lessons from physiological characteristics to fundamental material science knowledge, summarizing the pros and cons of nanotechnology applications in therapeutic drug delivery. The oral cavity presents inherent challenges, including oral cancer, dental caries, oral infection, or oral inflammation, that necessitate local solutions. Simultaneously, the vascular system under the tongue and in the buccal region offers a portal for systemic drug absorption. Expert opinion Among available delivery systems, nanoparticle-based drug delivery, with the oral cavity as the action or absorption site, can be developed as a principal dosage formulation. Although convenience and fast onset might be advantageous, additional studies are warranted for preclinical characterization, especially in animal models, and for determining manufacturing competence, prior to human trials to meet standards in clinical settings.
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Duyen Ha Thi Kim,Tien Ngo Manh,Cuong Nguyen Manh,Nhan Duc Nguyen,Dung Pham Tien,Manh Tran Van,Minh Phan Xuan 제어·로봇·시스템학회 2021 International Journal of Control, Automation, and Vol.19 No.4
The paper proposes the method to deal with control problems of unmodeled components of the fourwheeled Omni-directional mobile robot. It is commonly challenging to design a model-based control scheme to achieve smooth movement in the tracking process due to the unknown elements in the mathematical model of the robot or external disturbances. Our main contribution focuses on designing an adaptive controller based on neural networks with online weight updating laws and Fuzzy logic to guarantee the high accuracy of the robot’s movement when the unknown factors adversely affect the robot control. At the initial step, a Dynamic Surface Control plays a role as a core of the controller for the robot system. Then, with the ability to estimate the appropriate value for uncertain nonlinear parts, a Radial Basis Function Neural Network is designed. Finally, a Fuzzy law is to utilize control parameters in each period to increase the adaptive behavior of the system. The stability and convergence of the system are proven by the Lyapunov’s stability theory. The simulation results illustrate the validity and the efficiency of the proposed control algorithm when the system is lack of robot model’s information.
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Antimicrobial Activity of Phenolic-Rich Extracts from Mango Seed Kernel on Microorganisms
Tam Dang Thi Thu,Binh Ly Nguyen,Nhan Tran Chi,Loc Nguyen Bao,Phuong Nguyen Nhat Minh 한국미생물·생명공학회 2023 한국미생물·생명공학회지 Vol.51 No.4
Replacing synthetic additives to preserve food products with natural antimicrobial compounds needs to be considered due to public health. In the present study, the phenolic extract from mango seed kernel (MSK) with the total phenolic content (TPC) value of 5300 ± 380 mg gallic acid equivalent (GAE)/L was used for evaluating the antimicrobial properties against five types of bacterial strains, including Listeria monocytogenes, Escherichia coli, Pseudomonas aeruginosa, Staphylococcus aureus, and Salmonella typhimurium in vitro. This extract was also used for in situ method on the storage of Pangasianodon hypophthalmus fish fillets. The minimum inhibitory concentration (MIC) values for all tested strains were determined at an average concentration of 1325 mg GAE/L. Furthermore, the minimum bactericidal concentration (MBC) values of E. coli, S. aureus, and S. typhimurium were seen at 5300 mg GAE/L, while the extract did not show eliminations in the growth of the remaining strains. The bacterial inhibition speed of the extract illustrated that the concentration equal MIC value eliminated S. typhimurium growth after 24 h, the 4 times MIC value had remarkable effects on S. aureus growth after the 9 h of incubation, and 24 h of incubation for E. coli, L. monocytogenes, P. aeruginosa. Additionally, the MSK extract could inhibit the growth of P. aeruginosa on fish fillets in 4 days of storage. These results provide important evidence for the utilization of MSK as a natural source of antimicrobial agents in food products.
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Factors Affecting the Performance of Vietnamese Commercial Banks: Does Basel II Matter?
Duy Khang LE,Thi Minh Nhan TRAN,Van Diep NGUYEN 한국유통과학회 2022 The Journal of Asian Finance, Economics and Busine Vol.9 No.3
This paper examines the main factors affecting the bank performance under the Basel II implementation in Vietnam, a transitional economy in Asia. We pay special attention to the implementation duration of the Basel II convention and how it affects profitability. Thereby, we can evaluate the effectiveness of Basel II in the whole system according to the roadmap to 2020. We employ the panel data regression method to analyze a sample of 300 bank-year observations from 25 commercial banks during the 2008–2019 period. Our empirical findings show that the size of the bank, net interest margin, state ownership, and Basel II convention have positive effects on bank profitability. However, our empirical findings indicate that bank age and branch number negatively reduce bank performance. Finally, our results indicate that commercial banks earn extra profit from delaying the implementation of Basel II. However, commercial banks will encounter higher credit, and operational risks arising from delaying the implementation of Basel II standards. Therefore, our study contributes to the insights into the bank’s management to enhance profitability, especially after implementing Basel II in a transitional economy. Finally, our study also provides policy implications for bank managers and banking supervisory to maintain the sustainable development of the banking system.
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