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Clelia Callegari,Paola Algeri,Antonella Buzzi,Teresio Motta,Cinzia Manfredini,Sonia Maria Rota 대한산부인과학회 2019 Obstetrics & Gynecology Science Vol.62 No.6
Endometrial glassy cell carcinoma (EGCC) is a rare neoplasm, accounting for 0.5% of the carcinomas in theendometrium, composed of cells with granular eosinophilic or amphophilic cytoplasm, giving it a ground glassappearance. Till date, only 14 cases of this carcinoma have been reported. In this report, we have described a caseof EGCC to help define standard diagnostic criteria and better understand the course, ideal treatment, and accurateprognosis of this disease. We report a case of a 64-year-old woman diagnosed with EGCC after an abnormal papsmear. She underwent a hysteroscopy, which led to the histological diagnosis. Laparotomic total hysterectomy andbilateral salpingo-oophorectomy were performed with pelvic lymphadenectomy and peritoneal and omental biopsies. Final pathological examination confirmed the initial diagnosis. Pelvic nodes removed during surgery and peritonealand omental biopsies were negative for tumor cells. Treatment was considered appropriate and the patient did notrequire additional therapies. She was subsequently assigned to clinical follow-up and is alive, with no evidence of thedisease.
A rare melanoma feature with primary ovarian origin: a case report and the literature review
( Algeri Paola ),( Rota Sonia Maria ),( Carlini Laura ),( Nicoli Elena ),( Caruso Orlando ),( Motta Teresio ) 대한산부인과학회 2018 Obstetrics & Gynecology Science Vol.61 No.2
Primary ovarian melanoma arising on a mature ovarian cystic teratoma is extremely rare. As best of our knowledge, to date, 49 cases have been reported in literature. Few information was reported about best management and therapy. We present a case occurred in a 69-year-old woman, without symptoms, who come to our unit for stress incontinence. A pelvic mass was detected and, after imaging evaluation, surgery was performed. The diagnosis was ovarian melanoma arose on a mature teratoma. No other adjuvant treatment was proposed after surgery. She died 9 months after the first diagnosis. Primary ovarian melanoma is a definite entity associated with a variable natural history and poor prognosis. Differential diagnosis is a challenge for the pathologist, because it must be differentiated by metastatic melanoma. The corner stone treatment of this disease is surgery; however, chemotherapy, immunotherapy, and target therapy seem to have a role.